Multi-Facial, Non-Peptidic α-Helix Mimetics

por Lanning, Maryanna E., Fletcher, Steven
Publicado 2015

Tetrazole and acylsulfonamide bioisosteric replacements of the carboxylic acid in a dual MCL-1/BCL-x(L) inhibitor are tolerated

por Chen, Lijia, Lowe, Brandon, Fletcher, Steven
Publicado 2023

Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion

por Wang, Huabo, Sharma, Lokendra, Lu, Jie, Finch, Paul, Fletcher, Steven, Prochownik, Edward V.
Publicado 2015

Ethyl 2,5-di-tert-butyl-5-eth­oxy-4-oxo-4,5-di­hydro-1H-pyrrole-3-carboxyl­ate

por Rosen, Gerald M., Muralidharan, Sukumaran, Zavalij, Peter Y., Fletcher, Steven, Kao, Joseph P. Y.
Publicado 2013

Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly

por Chauhan, Jay, Yu, Wenbo, Cardinale, Steven, Opperman, Timothy J, MacKerell, Alexander D, Fletcher, Steven, de Leeuw, Erik PH
Publicado 2020

Structure–activity exploration of a small-molecule Lipid II inhibitor

por Fletcher, Steven, Yu, Wenbo, Huang, Jing, Kwasny, Steven M, Chauhan, Jay, Opperman, Timothy J, MacKerell, Alexander D, de Leeuw, Erik PH
Publicado 2015

Orthogonal targeting of osteoclasts and myeloma cells for radionuclide stimulated dynamic therapy induces multidimensional cell death pathways

por Zheleznyak, Alexander, Mixdorf, Matthew, Marsala, Lynne, Prior, Julie, Yang, Xiaoxia, Cui, Grace, Xu, Baogang, Fletcher, Steven, Fontana, Francesca, Lanza, Gregory, Achilefu, Samuel
Publicado 2021

Enabling reactive microscopy with MicroMator

por Fox, Zachary R., Fletcher, Steven, Fraisse, Achille, Aditya, Chetan, Sosa-Carrillo, Sebastián, Petit, Julienne, Gilles, Sébastien, Bertaux, François, Ruess, Jakob, Batt, Gregory
Publicado 2022

Mechanistic Analysis of an Extracellular Signal–Regulated Kinase 2–Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress

por Martinez, Ramon, Huang, Weiliang, Samadani, Ramin, Mackowiak, Bryan, Centola, Garrick, Chen, Lijia, Conlon, Ivie L., Hom, Kellie, Kane, Maureen A., Fletcher, Steven, Shapiro, Paul
Publicado 2021

The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition

por Peddaboina, Chander, Jupiter, Daniel, Fletcher, Steven, Yap, Jeremy L, Rai, Arun, Tobin, Richard P, Jiang, Weihua, Rascoe, Philip, Rogers, M Karen Newell, Smythe, W Roy, Cao, Xiaobo
Publicado 2012

A global map of saltmarshes

por Mcowen, Chris J, Weatherdon, Lauren V, Bochove, Jan-Willem Van, Sullivan, Emma, Blyth, Simon, Zockler, Christoph, Stanwell-Smith, Damon, Kingston, Naomi, Martin, Corinne S, Spalding, Mark, Fletcher, Steven
Publicado 2017

Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5

por Wang, Huabo, Chauhan, Jay, Hu, Angela, Pendleton, Kelsey, Yap, Jeremy L., Sabato, Philip E., Jones, Jace W., Perri, Mariarita, Yu, Jianshi, Cione, Erika, Kane, Maureen A., Fletcher, Steven, Prochownik, Edward V.
Publicado 2013

Erratum: Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5

por Wang, Huabo, Chauhan, Jay, Hu, Angela, Pendleton, Kelsey, Yap, Jeremy L., Sabato, Philip E., Jones, Jace W., Perri, Mariarita, Yu, Jianshi, Cione, Erika, Kane, Maureen A., Fletcher, Steven, Prochownik, Edward V.
Publicado 2018

STAT3 activity is necessary and sufficient for the development of immune-mediated myocarditis in mice and promotes progression to dilated cardiomyopathy

por Camporeale, Annalisa, Marino, Francesca, Papageorgiou, Anna, Carai, Paolo, Fornero, Sara, Fletcher, Steven, Page, Brent D G, Gunning, Patrick, Forni, Marco, Chiarle, Roberto, Morello, Mara, Jensen, Ole, Levi, Renzo, Heymans, Stephane, Poli, Valeria
Publicado 2013

The Bivalent Bromodomain Inhibitor MT-1 Inhibits Prostate Cancer Growth

por Shukla, Sanjeev, Riveros, Carlos, Al-Toubat, Mohammed, Chardon-Robles, Jonathan, Osumi, Teruko, Serrano, Samuel, Kase, Adam M., Petit, Joachim L., Meurice, Nathalie, Gleba, Justyna, Copland, John A., Chauhan, Jay, Fletcher, Steven, Balaji, K. C.
Publicado 2023

Towards Development of Small Molecule Lipid II Inhibitors as Novel Antibiotics

por Chauhan, Jamal, Cardinale, Steven, Fang, Lei, Huang, Jing, Kwasny, Steven M., Pennington, M. Ross, Basi, Kelly, diTargiani, Robert, Capacio, Benedict R., MacKerell, Alexander D., Opperman, Timothy J., Fletcher, Steven, de Leeuw, Erik P. H.
Publicado 2016

The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein int...

por Cao, Xiaobo, Yap, Jeremy L, Newell-Rogers, M Karen, Peddaboina, Chander, Jiang, Weihua, Papaconstantinou, Harry T, Jupitor, Dan, Rai, Arun, Jung, Kwan-Young, Tubin, Richard P, Yu, Wenbo, Vanommeslaeghe, Kenno, Wilder, Paul T, MacKerell, Alexander D, Fletcher, Steven, Smythe, Roy W
Publicado 2013

Nanotherapy delivery of c-myc inhibitor targets Protumor Macrophages and preserves Antitumor Macrophages in Breast Cancer

por Esser, Alison K., Ross, Michael H., Fontana, Francesca, Su, Xinming, Gabay, Ariel, Fox, Gregory C., Xu, Yalin, Xiang, Jingyu, Schmieder, Anne H., Yang, Xiaoxia, Cui, Grace, Scott, Michael, Achilefu, Samuel, Chauhan, Jay, Fletcher, Steven, Lanza, Gregory M., Weilbaecher, Katherine N.
Publicado 2020