Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?

por Fliegert, Ralf, Riekehr, Winnie M., Guse, Andreas H.
Publicado 2020

Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling

por Ernst, Insa M. A., Fliegert, Ralf, Guse, Andreas H.
Publicado 2013

The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn(2+)‐binding domain essential for structural integrity and channel activity

por Sander, Simon, Pick, Jelena, Gattkowski, Ellen, Fliegert, Ralf, Tidow, Henning
Publicado 2022

A Mathematical Model of T Lymphocyte Calcium Dynamics Derived from Single Transmembrane Protein Properties

por Schmeitz, Christine, Hernandez-Vargas, Esteban Abelardo, Fliegert, Ralf, Guse, Andreas H., Meyer-Hermann, Michael
Publicado 2013

Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9

por Gattkowski, Ellen, Rutherford, Trevor J., Möckl, Franziska, Bauche, Andreas, Sander, Simon, Fliegert, Ralf, Tidow, Henning
Publicado 2021

Activation of the P2X7 ion channel by soluble and covalently bound ligands

por Schwarz, Nicole, Fliegert, Ralf, Adriouch, Sahil, Seman, Michel, Guse, Andreas H., Haag, Friedrich, Koch-Nolte, Friedrich
Publicado 2009

cADPR Does Not Activate TRPM2

por Riekehr, Winnie Maria, Sander, Simon, Pick, Jelena, Tidow, Henning, Bauche, Andreas, Guse, Andreas H., Fliegert, Ralf
Publicado 2022

Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2

por Baszczyňski, Ondřej, Watt, Joanna M., Rozewitz, Monika D., Guse, Andreas H., Fliegert, Ralf, Potter, Barry V. L.
Publicado 2019

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5′-diphosphate ribose (ADPR)

por Baszczyňski, Ondřej, Watt, Joanna M., Rozewitz, Monika D., Fliegert, Ralf, Guse, Andreas H., Potter, Barry V. L.
Publicado 2020

Daratumumab and Nanobody-Based Heavy Chain Antibodies Inhibit the ADPR Cyclase but not the NAD(+) Hydrolase Activity of CD38-Expressing Multiple Myeloma Cells

por Baum, Natalie, Fliegert, Ralf, Bauche, Andreas, Hambach, Julia, Menzel, Stephan, Haag, Friedrich, Bannas, Peter, Koch-Nolte, Friedrich
Publicado 2020

Alternative Splicing of the N-Terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-Ribosylation

por Schwarz, Nicole, Drouot, Laurent, Nicke, Annette, Fliegert, Ralf, Boyer, Olivier, Guse, Andreas H., Haag, Friedrich, Adriouch, Sahil, Koch-Nolte, Friedrich
Publicado 2012

Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2

por Gattkowski, Ellen, Johnsen, Anke, Bauche, Andreas, Möckl, Franziska, Kulow, Frederike, Garcia Alai, Maria, Rutherford, Trevor J., Fliegert, Ralf, Tidow, Henning
Publicado 2019

Structure–Activity Relationship of Adenosine 5′-diphosphoribose at the Transient Receptor Potential Melastatin 2 (TRPM2) Channel: Rational Design of Antagonists

por Moreau, Christelle, Kirchberger, Tanja, Swarbrick, Joanna M., Bartlett, Stephen J., Fliegert, Ralf, Yorgan, Timur, Bauche, Andreas, Harneit, Angelika, Guse, Andreas H., Potter, Barry V. L.
Publicado 2013

Mouse CD38-Specific Heavy Chain Antibodies Inhibit CD38 GDPR-Cyclase Activity and Mediate Cytotoxicity Against Tumor Cells

por Baum, Natalie, Eggers, Marie, Koenigsdorf, Julia, Menzel, Stephan, Hambach, Julia, Staehler, Tobias, Fliegert, Ralf, Kulow, Frederike, Adam, Gerhard, Haag, Friedrich, Bannas, Peter, Koch-Nolte, Friedrich
Publicado 2021

8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist

por Kirchberger, Tanja, Moreau, Christelle, Wagner, Gerd K., Fliegert, Ralf, Siebrands, Cornelia C., Nebel, Merle, Schmid, Frederike, Harneit, Angelika, Odoardi, Francesca, Flügel, Alexander, Potter, Barry V. L., Guse, Andreas H.
Publicado 2009

P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP

por Johnsen, Bjarne, Kaschubowski, Klaus Eric, Nader, Sorush, Schneider, Enja, Nicola, Jan-Andrei, Fliegert, Ralf, Wolf, Insa M. A., Guse, Andreas H., Nikolaev, Viacheslav O., Koch-Nolte, Friedrich, Haag, Friedrich
Publicado 2019

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349

por Fliegert, Ralf, Watt, Joanna M., Schöbel, Anja, Rozewitz, Monika D., Moreau, Christelle, Kirchberger, Tanja, Thomas, Mark P., Sick, Wiebke, Araujo, Andrea C., Harneit, Angelika, Potter, Barry V.L., Guse, Andreas H.
Publicado 2017

Culturing and patch clamping of Jurkat T cells and neurons on Al(2)O(3) coated nanowire arrays of altered morphology

por Harberts, Jann, Zierold, Robert, Fendler, Cornelius, Koitmäe, Aune, Bayat, Parisa, Fernandez-Cuesta, Irene, Loers, Gabriele, Diercks, Björn-Philipp, Fliegert, Ralf, Guse, Andreas H., Ronning, Carsten, Otnes, Gaute, Borgström, Magnus, Blick, Robert H.
Publicado 2019

Correction: Culturing and patch clamping of Jurkat T cells and neurons on Al(2)O(3) coated nanowire arrays of altered morphology

por Harberts, Jann, Zierold, Robert, Fendler, Cornelius, Koitmäe, Aune, Bayat, Parisa, Fernandez-Cuesta, Irene, Loers, Gabriele, Diercks, Björn-Philipp, Fliegert, Ralf, Guse, Andreas H., Ronning, Carsten, Otnes, Gaute, Borgström, Magnus, Blick, Robert H.
Publicado 2019

Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin

por Stern, Louisa, Boehme, Lukas Fabian, Goetz, Mara Rebecca, Nitschke, Christine, Giannou, Anastasios, Zhang, Tao, Güngör, Cenap, Reeh, Matthias, Izbicki, Jakob Robert, Fliegert, Ralf, Hausen, Anne, Giese, Nathalia, Hackert, Thilo, Niv, Masha Y., Heinrich, Stefan, Gaida, Matthias Martin, Ghadban, Tarik
Publicado 2022