53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response

por Martínez, Paula, Flores, Juana M., Blasco, Maria A.
Publicado 2012

Essential role for the TRF2 telomere protein in adult skin homeostasis

por Martínez, Paula, Ferrara-Romeo, Iole, Flores, Juana M, Blasco, Maria A
Publicado 2014

In vivo role of checkpoint kinase 2 in signaling telomere dysfunction

por García-Beccaria, María, Martínez, Paula, Flores, Juana M, Blasco, Maria A
Publicado 2014

Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Increase Health Span and Extend Mouse Longevity

por Vera, Elsa, Bernardes de Jesus, Bruno, Foronda, Miguel, Flores, Juana M., Blasco, Maria A.
Publicado 2013

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance

por Martínez, Paula, Gómez‐López, Gonzalo, Pisano, David G., Flores, Juana M., Blasco, Maria A.
Publicado 2016

Safety of Whole-Body Abrogation of the TRF1 Shelterin Protein in Wild-Type and Cancer-Prone Mouse Models

por Bejarano, Leire, Louzame, Jessica, Montero, Juán José, Megías, Diego, Flores, Juana M., Blasco, Maria A.
Publicado 2019

A mouse model for Li-Fraumeni-Like Syndrome with cardiac angiosarcomas associated to POT1 mutations

por Martínez, Paula, Sánchez-Vázquez, Raúl, Ferrara-Romeo, Iole, Serrano, Rosa, Flores, Juana M., Blasco, Maria A.
Publicado 2022

Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation

por Foronda, Miguel, Martínez, Paula, Schoeftner, Stefan, Gómez-López, Gonzalo, Schneider, Ralph, Flores, Juana M., Pisano, David G., Blasco, Maria A.
Publicado 2014

RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression

por Martínez, Paula, Gómez-López, Gonzalo, García, Fernando, Mercken, Evi, Mitchell, Sarah, Flores, Juana M., de Cabo, Rafael, Blasco, Maria A.
Publicado 2013

Short Telomeres Result in Organismal Hypersensitivity to Ionizing Radiation in Mammals

por Goytisolo, Fermín A., Samper, Enrique, Martín-Caballero, Juan, Finnon, Paul, Herrera, Eloísa, Flores, Juana M., Bouffler, Simon D., Blasco, María A.
Publicado 2000

Normal Proliferation and Tumorigenesis but Impaired Pancreatic Function in Mice Lacking the Cell Cycle Regulator Sei1

por Fernandez-Marcos, Pablo J., Pantoja, Cristina, Gonzalez-Rodriguez, Agueda, Martin, Nicholas, Flores, Juana M., Valverde, Angela M., Hara, Eiji, Serrano, Manuel
Publicado 2010

Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs

por Espejel, Silvia, Klatt, Peter, Murcia, Josiane Ménissier-de, Martín-Caballero, Juan, Flores, Juana M., Taccioli, Guillermo, de Murcia, Gilbert, Blasco, María A.
Publicado 2004

G6PD protects from oxidative damage and improves healthspan in mice

por Nóbrega-Pereira, Sandrina, Fernandez-Marcos, Pablo J., Brioche, Thomas, Gomez-Cabrera, Mari Carmen, Salvador-Pascual, Andrea, Flores, Juana M., Viña, Jose, Serrano, Manuel
Publicado 2016

Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma

por Vallejo-Díaz, Jesús, Olazabal-Morán, Manuel, Cariaga-Martínez, Ariel E., Pajares, María J., Flores, Juana M., Pio, Ruben, Montuenga, Luis M., Carrera, Ana Clara
Publicado 2016

Growth Arrest Specific 1 (Gas1) Gene Overexpression in Liver Reduces the In Vivo Progression of Murine Hepatocellular Carcinoma and Partially Restores Gene Expression Levels

por Sacilotto, Natalia, Castillo, Josefa, Riffo-Campos, Ángela L., Flores, Juana M., Hibbitt, Olivia, Wade-Martins, Richard, López, Carlos, Rodrigo, M. Isabel, Franco, Luis, López-Rodas, Gerardo
Publicado 2015

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition

por Caffarel, María M, Andradas, Clara, Mira, Emilia, Pérez-Gómez, Eduardo, Cerutti, Camilla, Moreno-Bueno, Gema, Flores, Juana M, García-Real, Isabel, Palacios, José, Mañes, Santos, Guzmán, Manuel, Sánchez, Cristina
Publicado 2010

NOD1 Activation Induces Cardiac Dysfunction and Modulates Cardiac Fibrosis and Cardiomyocyte Apoptosis

por Fernández-Velasco, María, Prieto, Patricia, Terrón, Verónica, Benito, Gemma, Flores, Juana M., Delgado, Carmen, Zaragoza, Carlos, Lavin, Begoña, Gómez-Parrizas, Mónica, López-Collazo, Eduardo, Martín-Sanz, Paloma, Boscá, Lisardo
Publicado 2012

SOX9 promotes tumor progression through the axis BMI1-p21(CIP)

por Aldaz, Paula, Otaegi-Ugartemendia, Maddalen, Saenz-Antoñanzas, Ander, Garcia-Puga, Mikel, Moreno-Valladares, Manuel, Flores, Juana M., Gerovska, Daniela, Arauzo-Bravo, Marcos J., Samprón, Nicolas, Matheu, Ander, Carrasco-Garcia, Estefania
Publicado 2020

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-Ras(G12V)-induced lung cancer by induction of telomeric DNA damage

por García-Beccaria, María, Martínez, Paula, Méndez-Pertuz, Marinela, Martínez, Sonia, Blanco-Aparicio, Carmen, Cañamero, Marta, Mulero, Francisca, Ambrogio, Chiara, Flores, Juana M, Megias, Diego, Barbacid, Mariano, Pastor, Joaquín, Blasco, Maria A
Publicado 2015

Distinct p21 requirements for regulating normal and self-reactive T cells through IFN-γ production

por Daszkiewicz, Lidia, Vázquez-Mateo, Cristina, Rackov, Gorjana, Ballesteros-Tato, André, Weber, Kathrin, Madrigal-Avilés, Adrián, Di Pilato, Mauro, Fotedar, Arun, Fotedar, Rati, Flores, Juana M., Esteban, Mariano, Martínez-A, Carlos, Balomenos, Dimitrios
Publicado 2015