The SWI/SNF ATPase BRG1 facilitates multiple pro-tumorigenic gene expression programs in SMARCB1-deficient cancer cells

por Moe, Kylie C., Maxwell, Jack N., Wang, Jing, Jones, Cheyenne A., Csaki, Grace T., Florian, Andrea C., Romer, Alexander S., Bryant, Daniel L., Farone, Anthony L., Liu, Qi, Tansey, William P., Weissmiller, April M.
Publicado 2022

WIN site inhibition disrupts a subset of WDR5 function

por Siladi, Andrew J., Wang, Jing, Florian, Andrea C., Thomas, Lance R., Creighton, Joy H., Matlock, Brittany K., Flaherty, David K., Lorey, Shelly L., Howard, Gregory C., Fesik, Stephen W., Weissmiller, April M., Liu, Qi, Tansey, William P.
Publicado 2022

Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells

por Florian, Andrea C, Woodley, Chase M, Wang, Jing, Grieb, Brian C, Slota, Macey J, Guerrazzi, Kiana, Hsu, Chih-Yuan, Matlock, Brittany K, Flaherty, David K, Lorey, Shelly L, Fesik, Stephen W, Howard, Gregory C, Liu, Qi, Weissmiller, April M, Tansey, William P
Publicado 2022

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

por Howard, Gregory C., Wang, Jing, Rose, Kristie Lindsey, Patel, Purvi, Tsui, Tina, Florian, Andrea C., Lorey, Shelly L., Grieb, Brian C., Smith, Brianna N., Slota, Macey J., Reynolds, Elizabeth M., Goswami, Soumita, Savona, Michael R., Lee, Taekyu, Fesik, Stephen W., Liu, Qi, Tansey, William P.
Publicado 2023