Pyroptosis inhibiting nanobodies block Gasdermin D pore formation

por Kopp, Anja, Hagelueken, Gregor, Jamitzky, Isabell, Moecking, Jonas, Schiffelers, Lisa D. J., Schmidt, Florian I., Geyer, Matthias
Publicado 2023

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

por Schmidt, Florian I., Lu, Alvin, Chen, Jeff W., Ruan, Jianbin, Tang, Catherine, Wu, Hao, Ploegh, Hidde L.
Publicado 2016

Phenotypic lentivirus screens to identify functional single domain antibodies

por Schmidt, Florian I., Hanke, Leo, Morin, Benjamin, Brewer, Rebeccah, Brusic, Vesna, Whelan, Sean P.J., Ploegh, Hidde L.
Publicado 2016

The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment

por Hanke, Leo, Knockenhauer, Kevin E., Brewer, R. Camille, van Diest, Eline, Schmidt, Florian I., Schwartz, Thomas U., Ploegh, Hidde L.
Publicado 2016

The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity

por Ramirez Alvarez, Carlos, Kee, Carmon, Sharma, Ashwini Kumar, Thomas, Leonie, Schmidt, Florian I., Stanifer, Megan L., Boulant, Steeve, Herrmann, Carl
Publicado 2021

ASC oligomer favors caspase-1(CARD) domain recruitment after intracellular potassium efflux

por Martín-Sánchez, Fátima, Compan, Vincent, Peñín-Franch, Alejandro, Tapia-Abellán, Ana, Gómez, Ana I., Baños-Gregori, María C., Schmidt, Florian I., Pelegrin, Pablo
Publicado 2023

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans

por Tafesse, Fikadu G., Rashidfarrokhi, Ali, Schmidt, Florian I., Freinkman, Elizaveta, Dougan, Stephanie, Dougan, Michael, Esteban, Alexandre, Maruyama, Takeshi, Strijbis, Karin, Ploegh, Hidde L.
Publicado 2015

One-Dimensional (1D) Nanostructured Materials for Energy Applications

por Machín, Abniel, Fontánez, Kenneth, Arango, Juan C., Ortiz, Dayna, De León, Jimmy, Pinilla, Sergio, Nicolosi, Valeria, Petrescu, Florian I., Morant, Carmen, Márquez, Francisco
Publicado 2021

Molecular basis of caspase-1 polymerization and its inhibition by a novel capping mechanism

por Lu, Alvin, Li, Yang, Schmidt, Florian I., Yin, Qian, Chen, Shuobing, Fu, Tian-Min, Tong, Alexander B., Ploegh, Hidde L., Mao, Youdong, Wu, Hao
Publicado 2016

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

por Hansen, Jan N, Kaiser, Fabian, Klausen, Christina, Stüven, Birthe, Chong, Raymond, Bönigk, Wolfgang, Mick, David U, Möglich, Andreas, Jurisch-Yaksi, Nathalie, Schmidt, Florian I, Wachten, Dagmar
Publicado 2020

Photocatalytic Activity of Silver-Based Biomimetics Composites

por Machín, Abniel, Soto-Vázquez, Loraine, Colón-Cruz, Carla, Valentín-Cruz, Carlos A., Claudio-Serrano, Gerardo J., Fontánez, Kenneth, Resto, Edgard, Petrescu, Florian I., Morant, Carmen, Márquez, Francisco
Publicado 2021

Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever

por Mangan, Matthew S. J., Gorki, Friederike, Krause, Karoline, Heinz, Alexander, Pankow, Anne, Ebert, Thomas, Jahn, Dieter, Hiller, Karsten, Hornung, Veit, Maurer, Marcus, Schmidt, Florian I., Gerhard, Ralf, Latz, Eicke
Publicado 2022

Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

por Bosso, Matteo, Prelli Bozzo, Caterina, Hotter, Dominik, Volcic, Meta, Stürzel, Christina M., Rammelt, Annika, Ni, Yi, Urban, Stephan, Becker, Miriam, Schelhaas, Mario, Wittmann, Sabine, Christensen, Maria H., Schmidt, Florian I., Gramberg, Thomas, Sparrer, Konstantin M. J., Sauter, Daniel, Kirchhoff, Frank
Publicado 2020

Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo

por Bertheloot, Damien, Wanderley, Carlos WS, Schneider, Ayda H, Schiffelers, Lisa DJ, Wuerth, Jennifer D, Tödtmann, Jan MP, Maasewerd, Salie, Hawwari, Ibrahim, Duthie, Fraser, Rohland, Cornelia, Ribeiro, Lucas S, Jenster, Lea‐Marie, Rosero, Nathalia, Tesfamariam, Yonas M, Cunha, Fernando Q, Schmidt, Florian I, Franklin, Bernardo S
Publicado 2022

Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus

por Steiner, Annemarie, Reygaerts, Thomas, Pontillo, Alessandra, Ceccherini, Isabella, Moecking, Jonas, Moghaddas, Fiona, Davidson, Sophia, Caroli, Francesco, Grossi, Alice, Castro, Fabio Fernandes Morato, Kalil, Jorge, Gohr, Florian N., Schmidt, Florian I., Bartok, Eva, Zillinger, Thomas, Hartmann, Gunther, Geyer, Matthias, Gattorno, Marco, Mendonça, Leonardo Oliveira, Masters, Seth L.
Publicado 2021

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

por Jenster, Lea-Marie, Lange, Karl-Elmar, Normann, Sabine, vom Hemdt, Anja, Wuerth, Jennifer D., Schiffelers, Lisa D.J., Tesfamariam, Yonas M., Gohr, Florian N., Klein, Laura, Kaltheuner, Ines H., Ebner, Stefan, Lapp, Dorothee J., Mayer, Jacob, Moecking, Jonas, Ploegh, Hidde L., Latz, Eicke, Meissner, Felix, Geyer, Matthias, Kümmerer, Beate M., Schmidt, Florian I.
Publicado 2022

Review of global neurosurgery education: Horizon of Neurosurgery in the Developing Countries

por Kato, Y., Liew, B. S., Sufianov, A. A., Rasulic, L., Arnautovic, K. I., Dong, V. H., Florian, I. S., Olldashi, F., Makhambetov, Y., Isam, B., Thu, M., Enkhbayar, Ts., Kumarasinghe, N., Bajamal, A. H., Nair, S., Sharif, S., Sharma, M. R., Landeiro, J. A., Yampolsky, C. G., El-Ghandour, N. M. F., Hossain, A. M., Sim, S., Chemate, S., Burhan, Hira, Feng, L., Andrade, H., Germano, Isabelle M.
Publicado 2020

Correction to: Review of global neurosurgery education: Horizon of Neurosurgery in the Developing Countries

por Kato, Y., Liew, B. S., Sufianov, A. A., Rasulic, L., Arnautovic, K. I., Dong, V. H., Florian, I. S., Olldashi, F., Makhambetov, Y., Isam, B., Thu, M., Enkhbayar, Ts., Kumarasinghe, N., Bajamal, A. H., Nair, S., Sharif, S., Sharma, M. R., Landeiro, J. A., Yampolsky, C. G., El-Ghandour, N. M. F., Hossain, A. M., Sim, S., Chemate, S., Burhan, Hira, Feng, L., Andrade, H., Germano, Isabelle M.
Publicado 2020

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

por Koenig, Paul-Albert, Das, Hrishikesh, Liu, Hejun, Kümmerer, Beate M., Gohr, Florian N., Jenster, Lea-Marie, Schiffelers, Lisa D. J., Tesfamariam, Yonas M., Uchima, Miki, Wuerth, Jennifer D., Gatterdam, Karl, Ruetalo, Natalia, Christensen, Maria H., Fandrey, Caroline I., Normann, Sabine, Tödtmann, Jan M. P., Pritzl, Steffen, Hanke, Leo, Boos, Jannik, Yuan, Meng, Zhu, Xueyong, Schmid-Burgk, Jonathan L., Kato, Hiroki, Schindler, Michael, Wilson, Ian A., Geyer, Matthias, Ludwig, Kerstin U., Hällberg, B. Martin, Wu, Nicholas C., Schmidt, Florian I.
Publicado 2021

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

por Krämer, Benjamin, Knoll, Rainer, Bonaguro, Lorenzo, ToVinh, Michael, Raabe, Jan, Astaburuaga-García, Rosario, Schulte-Schrepping, Jonas, Kaiser, Kim Melanie, Rieke, Gereon J., Bischoff, Jenny, Monin, Malte B., Hoffmeister, Christoph, Schlabe, Stefan, De Domenico, Elena, Reusch, Nico, Händler, Kristian, Reynolds, Gary, Blüthgen, Nils, Hack, Gudrun, Finnemann, Claudia, Nischalke, Hans D., Strassburg, Christian P., Stephenson, Emily, Su, Yapeng, Gardner, Louis, Yuan, Dan, Chen, Daniel, Goldman, Jason, Rosenstiel, Philipp, Schmidt, Susanne V., Latz, Eicke, Hrusovsky, Kevin, Ball, Andrew J., Johnson, Joe M., Koenig, Paul-Albert, Schmidt, Florian I., Haniffa, Muzlifah, Heath, James R., Kümmerer, Beate M., Keitel, Verena, Jensen, Björn, Stubbemann, Paula, Kurth, Florian, Sander, Leif E., Sawitzki, Birgit, Aschenbrenner, Anna C., Schultze, Joachim L., Nattermann, Jacob
Publicado 2021