SAT-300 Evading Death: Noxa in Cushing’s Disease Pituitary Adenomas

por Alvarez, Reinier, Floros, Konstantinos, Johnson, Kory, Elkahloun, Abdel, Wu, Weiwei, Edwards, Nancy, Chaudhury, Abhik Ray, Nieman, Lynnette, Stratakis, Constantine, Chittiboina, Prashant
Publicado 2020

MYCN upregulates the transsulfuration pathway to suppress the ferroptotic vulnerability in MYCN-amplified neuroblastoma

por Floros, Konstantinos V., Chawla, Ayesha T., Johnson-Berro, Mia O., Khatri, Rishabh, Stamatouli, Angeliki M., Boikos, Sosipatros A., Dozmorov, Mikhail G., Cowart, L. Ashley, Faber, Anthony C.
Publicado 2022

Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors

por Floros, Konstantinos V., Jacob, Sheeba, Kurupi, Richard, Fairchild, Carter K., Hu, Bin, Puchalapalli, Madhavi, E. Koblinski, Jennifer, Dozmorov, Mikhail G., Boikos, Sosipatros A., Scaltriti, Maurizio, Faber, Anthony C.
Publicado 2021

Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA

por Fairchild, Carter K., Floros, Konstantinos V., Jacob, Sheeba, Coon, Colin M., Puchalapalli, Madhavi, Hu, Bin, Harada, Hisashi, Dozmorov, Mikhail G., Koblinski, Jennifer E., Smith, Steven C., Domson, Gregory, Leverson, Joel D., Souers, Andrew J., Takebe, Naoko, Ebi, Hiromichi, Faber, Anthony C., Boikos, Sosipatros A.
Publicado 2021

Genomic screening reveals ubiquitin-like modifier activating enzyme 1 as a potent and druggable target in c-MYC-high triple negative breast cancer models

por Jacob, Sheeba, Turner, Tia H, Cai, Jinyang, Floros, Konstantinos V, Yu, Ann K, Coon, Colin M, Khatri, Rishabh, Alzubi, Mohammad A, Jakubik, Charles T, Bouck, Ynes M, Puchalapalli, Madhavi, Shende, Mayuri, Dozmorov, Mikhail G, Boikos, Sosipatros A, Hu, Bin, Harrell, J Chuck, Benes, Cyril H, Koblinski, Jennifer E, Costa, Carlotta, Faber, Anthony C
Publicado 2022

Pharmacologic Inhibition of SHP2 Blocks Both PI3K and MEK Signaling in Low-epiregulin HNSCC via GAB1

por Kurupi, Richard, Floros, Konstantinos V., Jacob, Sheeba, Chawla, Ayesha T., Cai, Jinyang, Hu, Bin, Puchalapalli, Madhavi, Coon, Colin M., Khatri, Rishabh, Crowther, Giovanna Stein, Egan, Regina K., Murchie, Ellen, Greninger, Patricia, Dalton, Krista M., Ghotra, Maninderjit S., Boikos, Sosipatros A., Koblinski, Jennifer E., Harada, Hisashi, Sun, Yue, Morgan, Iain M., Basu, Devraj, Dozmorov, Mikhail G., Benes, Cyril H., Faber, Anthony C.
Publicado 2022

Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy

por Floros, Konstantinos V., Lochmann, Timothy L., Hu, Bin, Monterrubio, Carles, Hughes, Mark T., Wells, Jason D., Morales, Cristina Bernadó, Ghotra, Maninderjit S., Costa, Carlotta, Souers, Andrew J., Boikos, Sosipatros A., Leverson, Joel D., Tan, Ming, Serra, Violeta, Koblinski, Jennifer E., Arribas, Joaquin, Prat, Aleix, Paré, Laia, Miller, Todd W., Dozmorov, Mikhail G., Harada, Hisashi, Windle, Brad E., Scaltriti, Maurizio, Faber, Anthony C.
Publicado 2018

Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination

por Ham, Jungoh, Costa, Carlotta, Sano, Renata, Lochmann, Timothy L., Sennott, Erin M., Patel, Neha U., Dastur, Anahita, Gomez-Caraballo, Maria, Krytska, Kateryna, Hata, Aaron N., Floros, Konstantinos V., Hughes, Mark T., Jakubik, Charles T., Heisey, Daniel A.R., Ferrell, Justin T., Bristol, Molly L., March, Ryan J., Yates, Craig, Hicks, Mark A., Nakajima, Wataru, Gowda, Madhu, Windle, Brad E., Dozmorov, Mikhail G., Garnett, Mathew J., McDermott, Ultan, Harada, Hisashi, Taylor, Shirley M., Morgan, Iain M., Benes, Cyril H., Engelman, Jeffrey A., Mossé, Yael P., Faber, Anthony C.
Publicado 2016