Induced Pluripotent Stem Cells to Model Juvenile Myelomonocytic Leukemia: New Perspectives for Preclinical Research

por Wehbe, Zeinab, Ghanjati, Foued, Flotho, Christian
Publicado 2021

Current Treatment of Juvenile Myelomonocytic Leukemia

por Mayerhofer, Christina, Niemeyer, Charlotte M., Flotho, Christian
Publicado 2021

P1000: JUVENILE MYELOMONOCYTIC LEUKEMIA (JMML) INHIBITS T CELL PROLIFERATION VIA THE ECTONUCLEOTIDASE CD39 AND THE PURINERGIC NETWORK

por Rajak, Jovana, Koleci, Naile, Mesesan, Andreea, Flotho, Christian, Niemeyer, Charlotte, Bengsch, Bertram, Erlacher, Miriam
Publicado 2023

The epigenetics of breast cancer – Opportunities for diagnostics, risk stratification and therapy

por Schröder, Rieke, Illert, Anna-Lena, Erbes, Thalia, Flotho, Christian, Lübbert, Michael, Duque-Afonso, Jesús
Publicado 2021

Proteomic Analysis of an Induced Pluripotent Stem Cell Model Reveals Strategies to Treat Juvenile Myelomonocytic Leukemia

por Pearson, Stella, Guo, Baoqiang, Pierce, Andrew, Azadbakht, Narges, Brazzatti, Julie A., Patassini, Stefano, Mulero-Navarro, Sonia, Meyer, Stefan, Flotho, Christian, Gelb, Bruce D., Whetton, Anthony D.
Publicado 2019

CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia

por Fluhr, Silvia, Boerries, Melanie, Busch, Hauke, Symeonidi, Aikaterini, Witte, Tania, Lipka, Daniel B, Mücke, Oliver, Nöllke, Peter, Krombholz, Christopher Felix, Niemeyer, Charlotte M, Plass, Christoph, Flotho, Christian
Publicado 2016

Abnormal B-Cell Maturation and Increased Transitional B Cells in CBL Syndrome

por Saettini, Francesco, Coliva, Tiziana Angela, Vendemini, Francesca, Galbiati, Marta, Bugarin, Cristina, Masetti, Riccardo, Moratto, Daniele, Chiarini, Marco, Guerra, Fabiola, Iascone, Maria, Badolato, Raffaele, Cazzaniga, Giovanni, Niemeyer, Charlotte, Flotho, Christian, Biondi, Andrea
Publicado 2022

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia

por Stieglitz, Elliot, Mazor, Tali, Olshen, Adam B., Geng, Huimin, Gelston, Laura C., Akutagawa, Jon, Lipka, Daniel B., Plass, Christoph, Flotho, Christian, Chehab, Farid F., Braun, Benjamin S., Costello, Joseph F., Loh, Mignon L.
Publicado 2017

Epigenetic Profiling of PTPN11 Mutant JMML Hematopoietic Stem and Progenitor Cells Reveals an Aberrant Histone Landscape

por Sinha, Roshani, Dvorak, Mai, Ganesan, Ananthakrishnan, Kalesinskas, Larry, Niemeyer, Charlotte M., Flotho, Christian, Sakamoto, Kathleen M., Lacayo, Norman, Patil, Rachana Vinay, Perriman, Rhonda, Cepika, Alma-Martina, Liu, Yunying Lucy, Kuo, Alex, Utz, Paul J., Khatri, Purvesh, Bertaina, Alice
Publicado 2023

CircRNAs Dysregulated in Juvenile Myelomonocytic Leukemia: CircMCTP1 Stands Out

por Dal Molin, Anna, Hofmans, Mattias, Gaffo, Enrico, Buratin, Alessia, Cavé, Hélène, Flotho, Christian, de Haas, Valerie, Niemeyer, Charlotte M., Stary, Jan, Van Vlierberghe, Pieter, Philippé, Jan, De Moerloose, Barbara, te Kronnie, Geertruij, Bresolin, Silvia, Lammens, Tim, Bortoluzzi, Stefania
Publicado 2021

Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia

por Hofmans, Mattias, Lammens, Tim, Depreter, Barbara, Wu, Ying, Erlacher, Miriam, Caye, Aurélie, Cavé, Hélène, Flotho, Christian, de Haas, Valerie, Niemeyer, Charlotte M., Stary, Jan, Van Nieuwerburgh, Filip, Deforce, Dieter, Van Loocke, Wouter, Van Vlierberghe, Pieter, Philippé, Jan, De Moerloose, Barbara
Publicado 2021

MicroRNA fingerprints in juvenile myelomonocytic leukemia (JMML) identified miR-150-5p as a tumor suppressor and potential target for treatment

por Leoncini, Pier Paolo, Bertaina, Alice, Papaioannou, Dimitrios, Flotho, Christian, Masetti, Riccardo, Bresolin, Silvia, Menna, Giuseppe, Santoro, Nicola, Zecca, Marco, Basso, Giuseppe, Nigita, Giovanni, Veneziano, Dario, Pagotto, Sara, D'Ovidio, Katia, Rota, Rossella, Dorrance, Adrienne, Croce, Carlo M., Niemeyer, Charlotte, Locatelli, Franco, Garzon, Ramiro
Publicado 2016

Hypersensitivity Reactions to Native E. coli L-asparaginase in Children With Acute Lymphoblastic Leukemia Treated in Trial ALL-BFM 2000: Impact of Treatment Schedule and Type of Gl...

por Möricke, Anja, Rizzari, Carmelo, Alten, Julia, Attarbaschi, Andishe, Beier, Rita, Biondi, Andrea, Burkhardt, Birgit, Bodmer, Nicole, Boos, Joachim, Cario, Gunnar, Conter, Valentino, Flotho, Christian, Kulozik, Andreas, Lanvers-Kaminsky, Claudia, Mann, Georg, Niggli, Felix, Silvestri, Daniela, von Stackelberg, Arend, Stanulla, Martin, Valsecchi, Maria-Grazia, Schrappe, Martin, Zimmermann, Martin
Publicado 2023

Improved survival and MRD remission with blinatumomab vs. chemotherapy in children with first high-risk relapse B-ALL

por Locatelli, Franco, Zugmaier, Gerhard, Rizzari, Carmelo, Morris, Joan D., Gruhn, Bernd, Klingebiel, Thomas, Parasole, Rosanna, Linderkamp, Christin, Flotho, Christian, Petit, Arnaud, Micalizzi, Concetta, Zeng, Yi, Desai, Rajendra, Kormany, William N., Eckert, Cornelia, Möricke, Anja, Sartor, Mary, Hrusak, Ondrej, Peters, Christina, Saha, Vaskar, Vinti, Luciana, von Stackelberg, Arend
Publicado 2022

Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia

por Stanulla, Martin, Schaeffeler, Elke, Möricke, Anja, Buchmann, Swantje, Zimmermann, Martin, Igel, Svitlana, Schmiegelow, Kjeld, Flotho, Christian, Hartmann, Hans, Illsinger, Sabine, Sauerbrey, Axel, Junk, Stefanie V., Schütte, Peter, Hinze, Laura, Lauten, Melchior, Modlich, Simon, Kolb, Reinhard, Rossig, Claudia, Schwabe, Georg, Gnekow, Astrid K., Fleischhack, Gudrun, Schlegel, Paul Gerhard, Schünemann, Holger J., Kratz, Christian P., Cario, Gunnar, Schrappe, Martin, Schwab, Matthias
Publicado 2021

Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia

por van Tilburg, Cornelis M., Milde, Till, Witt, Ruth, Ecker, Jonas, Hielscher, Thomas, Seitz, Angelika, Schenk, Jens-Peter, Buhl, Juliane L., Riehl, Dennis, Frühwald, Michael C., Pekrun, Arnulf, Rossig, Claudia, Wieland, Regina, Flotho, Christian, Kordes, Uwe, Gruhn, Bernd, Simon, Thorsten, Linderkamp, Christin, Sahm, Felix, Taylor, Lenka, Freitag, Angelika, Burhenne, Jürgen, Foerster, Kathrin I., Meid, Andreas D., Pfister, Stefan M., Karapanagiotou-Schenkel, Irini, Witt, Olaf
Publicado 2019

Second allogeneic stem cell transplantation can rescue a significant proportion of patients with JMML relapsing after first allograft

por Vinci, Luca, Flotho, Christian, Noellke, Peter, Lebrecht, Dirk, Masetti, Riccardo, de Haas, Valerie, De Moerloose, Barbara, Dworzak, Michael, Hasle, Henrik, Güngör, Tayfun, Starý, Jan, Turkiewicz, Dominik, Ussowicz, Marek, de Heredia, Cristina Diaz, Buechner, Jochen, Jahnukainen, Kirsi, Kallay, Krisztian, Bodova, Ivana, Smith, Owen P., Zecca, Marco, Bresters, Dorine, Lang, Peter, Masmas, Tania Nicole, Meisel, Roland, Pichler, Herbert, Erlacher, Miriam, Göhring, Gudrun, Locatelli, Franco, Strahm, Brigitte, Niemeyer, Charlotte M., Yoshimi, Ayami
Publicado 2023

S206: ONCO-FETAL REPROGRAMMING DRIVES HIGH-RISK JUVENILE MYELOMONOCYTIC LEUKEMIA, WHICH CAN BE TARGETED BY ANTI-CD52 TREATMENT

por Hartmann, Mark, Schönung, Maximilian, Rajak, Jovana, Hey, Joschka, Maurer, Valentin, Hai, Ling, Staeble, Sina, Langstein, Jens, Bauer, Katharina, Hakobyan, Mariam, Jardine, Laura, Bohler, Sheila, Vonficht, Dominik, Maag, Abdul-Habib, Lebrecht, Dirk, Bernt, Kathrin, Rölz, Roland, Boch, Tobias, Khabirova, Eleonora, Lutsik, Pavlo, Haas, Simon, Haniffa, Muzlifah, Behjati, Sam, Mallm, Jan-Philipp, Buske, Christian, Milsom, Michael, Fröhling, Stefan, Bonder, Marc-Jan, Plass, Christoph, Niemeyer, Charlotte, Flotho, Christian, Erlacher, Miriam, Schlesner, Matthias, Lipka, Daniel B.
Publicado 2023

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia

por Niemeyer, Charlotte M., Kang, Michelle W., Shin, Danielle H., Furlan, Ingrid, Erlacher, Miriam, Bunin, Nancy J, Bunda, Severa, Finklestein, Jerry Z., Gorr, Thomas A., Mehta, Parinda, Schmid, Irene, Kropshofer, Gabriele, Corbacioglu, Selim, Lang, Peter J, Klein, Christoph, Schlegel, Paul-Gerhard, Heinzmann, Andrea, Schneider, Michaela, Starý, Jan, van den Heuvel-Eibrink, Marry M., Hasle, Henrik, Locatelli, Franco, Sakai, Debbie, Archambeault, Sophie, Chen, Leslie, Russell, Ryan C., Sybingco, Stephanie S., Ohh, Michael, Braun, Benjamin S., Flotho, Christian, Loh, Mignon L.
Publicado 2010

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia

por Lipka, Daniel B., Witte, Tania, Toth, Reka, Yang, Jing, Wiesenfarth, Manuel, Nöllke, Peter, Fischer, Alexandra, Brocks, David, Gu, Zuguang, Park, Jeongbin, Strahm, Brigitte, Wlodarski, Marcin, Yoshimi, Ayami, Claus, Rainer, Lübbert, Michael, Busch, Hauke, Boerries, Melanie, Hartmann, Mark, Schönung, Maximilian, Kilik, Umut, Langstein, Jens, Wierzbinska, Justyna A., Pabst, Caroline, Garg, Swati, Catalá, Albert, De Moerloose, Barbara, Dworzak, Michael, Hasle, Henrik, Locatelli, Franco, Masetti, Riccardo, Schmugge, Markus, Smith, Owen, Stary, Jan, Ussowicz, Marek, van den Heuvel-Eibrink, Marry M., Assenov, Yassen, Schlesner, Matthias, Niemeyer, Charlotte, Flotho, Christian, Plass, Christoph
Publicado 2017