Using Structure-guided Fragment-Based Drug Discovery to Target Pseudomonas aeruginosa Infections in Cystic Fibrosis

por Arif, Sheikh Mohammed, Floto, R. Andres, Blundell, Tom L.
Publicado 2022

Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation

por Bernut, Audrey, Loynes, Catherine A., Floto, R. Andres, Renshaw, Stephen A.
Publicado 2020

Development and validation of a CRISPR interference system for gene regulation in Campylobacter jejuni

por Costigan, Ruby, Stoakes, Emily, Floto, R. Andres, Parkhill, Julian, Grant, Andrew J.
Publicado 2022

Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19

por Bannerman, Bridget P, Júlvez, Jorge, Oarga, Alexandru, Blundell, Tom L, Moreno, Pablo, Floto, R Andres
Publicado 2021

Mabellini: a genome-wide database for understanding the structural proteome and evaluating prospective antimicrobial targets of the emerging pathogen Mycobacterium abscessus

por Skwark, Marcin J, Torres, Pedro H M, Copoiu, Liviu, Bannerman, Bridget, Floto, R Andres, Blundell, Tom L
Publicado 2019

Mycobacterium abscessus Complex Identification with Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry

por Panagea, Theofano, Pincus, David H., Grogono, Dorothy, Jones, Melissa, Bryant, Josephine, Parkhill, Julian, Floto, R. Andres, Gilligan, Peter
Publicado 2015

Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung

por Dang, Anh Thu, Begka, Christina, Pattaroni, Céline, Caley, Laura R., Floto, R. Andres, Peckham, Daniel G., Marsland, Benjamin J.
Publicado 2023

Lithium induces autophagy by inhibiting inositol monophosphatase

por Sarkar, Sovan, Floto, R. Andres, Berger, Zdenek, Imarisio, Sara, Cordenier, Axelle, Pasco, Matthieu, Cook, Lynnette J., Rubinsztein, David C.
Publicado 2005

Evaluating Listening Performance for COVID-19 Detection by Clinicians and Machine Learning: Comparative Study

por Han, Jing, Montagna, Marco, Grammenos, Andreas, Xia, Tong, Bondareva, Erika, Siegele-Brown, Chloë, Chauhan, Jagmohan, Dang, Ting, Spathis, Dimitris, Floto, R Andres, Cicuta, Pietro, Mascolo, Cecilia
Publicado 2023

Monocyte Function in Parkinson's Disease and the Impact of Autologous Serum on Phagocytosis

por Wijeyekoon, Ruwani S., Kronenberg-Versteeg, Deborah, Scott, Kirsten M., Hayat, Shaista, Jones, Joanne L., Clatworthy, Menna R., Floto, R. Andres, Barker, Roger A., Williams-Gray, Caroline H.
Publicado 2018

Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to Streptococcus pneumoniae

por Periselneris, Jimstan, Ercoli, Giuseppe, Pollard, Tracey, Chimalapati, Suneeta, Camberlein, Emilie, Szylar, Gabriella, Hyams, Catherine, Tomlinson, Gillian, Petersen, Fernanda C., Floto, R. Andres, Noursadeghi, Mahdad, Brown, Jeremy S.
Publicado 2019

Dissemination of Mycobacterium abscessus via global transmission networks

por Ruis, Christopher, Bryant, Josephine M., Bell, Scott C., Thomson, Rachel, Davidson, Rebecca M., Hasan, Nabeeh A., van Ingen, Jakko, Strong, Michael, Floto, R. Andres, Parkhill, Julian
Publicado 2021

Exploring Longitudinal Cough, Breath, and Voice Data for COVID-19 Progression Prediction via Sequential Deep Learning: Model Development and Validation

por Dang, Ting, Han, Jing, Xia, Tong, Spathis, Dimitris, Bondareva, Erika, Siegele-Brown, Chloë, Chauhan, Jagmohan, Grammenos, Andreas, Hasthanasombat, Apinan, Floto, R Andres, Cicuta, Pietro, Mascolo, Cecilia
Publicado 2022

Mutational spectra are associated with bacterial niche

por Ruis, Christopher, Weimann, Aaron, Tonkin-Hill, Gerry, Pandurangan, Arun Prasad, Matuszewska, Marta, Murray, Gemma G. R., Lévesque, Roger C., Blundell, Tom L., Floto, R. Andres, Parkhill, Julian
Publicado 2023

Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping

por Thomas, Sherine E., Collins, Patrick, James, Rory Hennell, Mendes, Vitor, Charoensutthivarakul, Sitthivut, Radoux, Chris, Abell, Chris, Coyne, Anthony G., Floto, R. Andres, von Delft, Frank, Blundell, Tom L.
Publicado 2019

Increased Virulence of Outer Membrane Porin Mutants of Mycobacterium abscessus

por de Moura, Vinicius C. N., Verma, Deepshikha, Everall, Isobel, Brown, Karen P., Belardinelli, Juan M., Shanley, Crystal, Stapleton, Megan, Parkhill, Julian, Floto, R. Andres, Ordway, Diane J., Jackson, Mary
Publicado 2021

A lung-specific mutational signature enables inference of viral and bacterial respiratory niche

por Ruis, Christopher, Peacock, Thomas P., Polo, Luis M., Masone, Diego, Alvarez, Maria Soledad, Hinrichs, Angie S., Turakhia, Yatish, Cheng, Ye, McBroome, Jakob, Corbett-Detig, Russell, Parkhill, Julian, Floto, R. Andres
Publicado 2023

Distinct cell-specific control of autoimmunity and infection by FcγRIIb

por Brownlie, Rebecca J., Lawlor, Kate E., Niederer, Heather A., Cutler, Antony J., Xiang, Zou, Clatworthy, Menna R., Floto, R. Andres, Greaves, David R., Lyons, Paul A., Smith, Kenneth G.C.
Publicado 2008

Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design

por Thomas, Sherine E., McCarthy, William J., El Bakali, Jamal, Brown, Karen P., Kim, So Yeon, Blaszczyk, Michal, Mendes, Vítor, Abell, Chris, Floto, R. Andres, Coyne, Anthony G., Blundell, Tom L.
Publicado 2022

Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study

por Bryant, Josephine M, Grogono, Dorothy M, Greaves, Daniel, Foweraker, Juliet, Roddick, Iain, Inns, Thomas, Reacher, Mark, Haworth, Charles S, Curran, Martin D, Harris, Simon R, Peacock, Sharon J, Parkhill, Julian, Floto, R Andres
Publicado 2013