MSH3 modifies somatic instability and disease severity in Huntington’s and myotonic dystrophy type 1

por Flower, Michael, Lomeikaite, Vilija, Ciosi, Marc, Cumming, Sarah, Morales, Fernando, Lo, Kitty, Hensman Moss, Davina, Jones, Lesley, Holmans, Peter, Monckton, Darren G, Tabrizi, Sarah J
Publicado 2019

FAN1 modifies Huntington’s disease progression by stabilizing the expanded HTT CAG repeat

por Goold, Robert, Flower, Michael, Moss, Davina Hensman, Medway, Chris, Wood-Kaczmar, Alison, Andre, Ralph, Farshim, Pamela, Bates, Gill P, Holmans, Peter, Jones, Lesley, Tabrizi, Sarah J
Publicado 2019

Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington’s disease

por Papoutsi, Marina, Flower, Michael, Hensman Moss, Davina J, Holmans, Peter, Estevez-Fraga, Carlos, Johnson, Eileanoir B, Scahill, Rachael I, Rees, Geraint, Langbehn, Douglas, Tabrizi, Sarah J
Publicado 2022

Abnormal molecular signatures of inflammation, energy metabolism, and vesicle biology in human Huntington disease peripheral tissues

por Neueder, Andreas, Kojer, Kerstin, Hering, Tanja, Lavery, Daniel J., Chen, Jian, Birth, Nathalie, Hallitsch, Jaqueline, Trautmann, Sonja, Parker, Jennifer, Flower, Michael, Sethi, Huma, Haider, Salman, Lee, Jong-Min, Tabrizi, Sarah J., Orth, Michael
Publicado 2022

FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington’s disease

por Goold, Robert, Hamilton, Joseph, Menneteau, Thomas, Flower, Michael, Bunting, Emma L., Aldous, Sarah G., Porro, Antonio, Vicente, José R., Allen, Nicholas D., Wilkinson, Hilary, Bates, Gillian P., Sartori, Alessandro A., Thalassinos, Konstantinos, Balmus, Gabriel, Tabrizi, Sarah J.
Publicado 2021

A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes

por Ciosi, Marc, Maxwell, Alastair, Cumming, Sarah A., Hensman Moss, Davina J., Alshammari, Asma M., Flower, Michael D., Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A.C., Holmans, Peter, Jones, Lesley, Langbehn, Douglas R., Kwak, Seung, Tabrizi, Sarah J., Monckton, Darren G.
Publicado 2019

Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington’S Disease Model

por Landles, Christian, Milton, Rebecca E, Ali, Nadira, Flomen, Rachel, Flower, Michael, Schindler, Franziska, Gomez-Paredes, Casandra, Bondulich, Marie K, Osborne, Georgina F, Goodwin, Daniel, Salsbury, Grace, Benn, Caroline L, Sathasivam, Kirupa, Smith, Edward J, Tabrizi, Sarah J, Wanker, Erich E, Bates, Gillian P
Publicado 2020

Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s disease

por Hensman Moss, Davina J., Flower, Michael D., Lo, Kitty K., Miller, James R. C., van Ommen, Gert-Jan B., ’t Hoen, Peter A. C., Stone, Timothy C., Guinee, Amelia, Langbehn, Douglas R., Jones, Lesley, Plagnol, Vincent, van Roon-Mom, Willeke M. C., Holmans, Peter, Tabrizi, Sarah J.
Publicado 2017

DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases

por Bettencourt, Conceição, Hensman‐Moss, Davina, Flower, Michael, Wiethoff, Sarah, Brice, Alexis, Goizet, Cyril, Stevanin, Giovanni, Koutsis, Georgios, Karadima, Georgia, Panas, Marios, Yescas‐Gómez, Petra, García‐Velázquez, Lizbeth Esmeralda, Alonso‐Vilatela, María Elisa, Lima, Manuela, Raposo, Mafalda, Traynor, Bryan, Sweeney, Mary, Wood, Nicholas, Giunti, Paola, Durr, Alexandra, Holmans, Peter, Houlden, Henry, Tabrizi, Sarah J., Jones, Lesley
Publicado 2016