Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

por Pillow, Thomas H., Sadowsky, Jack D., Zhang, Donglu, Yu, Shang-Fan, Del Rosario, Geoffrey, Xu, Keyang, He, Jintang, Bhakta, Sunil, Ohri, Rachana, Kozak, Katherine R., Ha, Edward, Junutula, Jagath R., Flygare, John A.
Publicado 2017

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes

por Hewings, David S., Heideker, Johanna, Ma, Taylur P., AhYoung, Andrew P., El Oualid, Farid, Amore, Alessia, Costakes, Gregory T., Kirchhofer, Daniel, Brasher, Bradley, Pillow, Thomas, Popovych, Nataliya, Maurer, Till, Schwerdtfeger, Carsten, Forrest, William F., Yu, Kebing, Flygare, John, Bogyo, Matthew, Wertz, Ingrid E.
Publicado 2018

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

por Heise, Christopher E., Murray, Jeremy, Augustyn, Katherine E., Bravo, Brandon, Chugha, Preeti, Cohen, Frederick, Giannetti, Anthony M., Gibbons, Paul, Hannoush, Rami N., Hearn, Brian R., Jaishankar, Priyadarshini, Ly, Cuong Q., Shah, Kinjalkumar, Stanger, Karen, Steffek, Micah, Tang, Yinyan, Zhao, Xianrui, Lewcock, Joseph W., Renslo, Adam R., Flygare, John, Arkin, Michelle R.
Publicado 2012

Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X(L) Inhibitor

por Wang, Le, Doherty, George A., Judd, Andrew S., Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R., Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R., Wang, Xilu, Wendt, Michael D., Flygare, John A., Catron, Nathaniel D., Judge, Russell A., Park, Chang H., Shekhar, Shashank, Phillips, Darren C., Nimmer, Paul, Smith, Morey L., Tahir, Stephen K., Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N., Mitten, Michael J., Boghaert, Erwin R., Gao, Wenqing, Kovar, Peter, Choo, Edna F., Diaz, Dolores, Fairbrother, Wayne J., Elmore, Steven W., Sampath, Deepak, Leverson, Joel D., Souers, Andrew James
Publicado 2020