Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition

por LaRochelle, Jonathan R., Fodor, Michelle, Vemulapalli, Vidyasiri, Mohseni, Morvarid, Wang, Ping, Stams, Travis, LaMarche, Matthew J., Chopra, Rajiv, Acker, Michael G., Blacklow, Stephen C.
Publicado 2018

A capillary-based microfluidic device enables primary high-throughput room-temperature crystallographic screening

por Sui, Shuo, Mulichak, Anne, Kulathila, Raviraj, McGee, Joshua, Filiatreault, Danny, Saha, Sarthak, Cohen, Aina, Song, Jinhu, Hung, Holly, Selway, Jonathan, Kirby, Christina, Shrestha, Om K., Weihofen, Wilhelm, Fodor, Michelle, Xu, Mei, Chopra, Rajiv, Perry, Sarah L.
Publicado 2021

ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor

por Mounir, Zineb, Korn, Joshua M, Westerling, Thomas, Lin, Fallon, Kirby, Christina A, Schirle, Markus, McAllister, Gregg, Hoffman, Greg, Ramadan, Nadire, Hartung, Anke, Feng, Yan, Kipp, David Randal, Quinn, Christopher, Fodor, Michelle, Baird, Jason, Schoumacher, Marie, Meyer, Ronald, Deeds, James, Buchwalter, Gilles, Stams, Travis, Keen, Nicholas, Sellers, William R, Brown, Myles, Pagliarini, Raymond A
Publicado 2016

Structure of the MRAS–SHOC2–PP1C phosphatase complex

por Hauseman, Zachary J., Fodor, Michelle, Dhembi, Anxhela, Viscomi, Jessica, Egli, David, Bleu, Melusine, Katz, Stephanie, Park, Eunyoung, Jang, Dong Man, Porter, Kathryn A., Meili, Fabian, Guo, Hongqiu, Kerr, Grainne, Mollé, Sandra, Velez-Vega, Camilo, Beyer, Kim S., Galli, Giorgio G., Maira, Saveur-Michel, Stams, Travis, Clark, Kirk, Eck, Michael J., Tordella, Luca, Thoma, Claudio R., King, Daniel A.
Publicado 2022