Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

por Tsukumo, Yoshinori, Alain, Tommy, Fonseca, Bruno D., Nadon, Robert, Sonenberg, Nahum
Publicado 2016

Regulation of mTORC1 Signaling by pH

por Balgi, Aruna D., Diering, Graham H., Donohue, Elizabeth, Lam, Karen K. Y., Fonseca, Bruno D., Zimmerman, Carla, Numata, Masayuki, Roberge, Michel
Publicado 2011

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

por Balgi, Aruna D., Fonseca, Bruno D., Donohue, Elizabeth, Tsang, Trevor C. F., Lajoie, Patrick, Proud, Christopher G., Nabi, Ivan R., Roberge, Michel
Publicado 2009

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

por Lahr, Roni M, Fonseca, Bruno D, Ciotti, Gabrielle E, Al-Ashtal, Hiba A, Jia, Jian-Jun, Niklaus, Marius R, Blagden, Sarah P, Alain, Tommy, Berman, Andrea J
Publicado 2017

The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction

por Smith, Ewan M, Benbahouche, Nour El Houda, Morris, Katherine, Wilczynska, Ania, Gillen, Sarah, Schmidt, Tobias, Meijer, Hedda A, Jukes-Jones, Rebekah, Cain, Kelvin, Jones, Carolyn, Stoneley, Mark, Waldron, Joseph A, Bell, Cameron, Fonseca, Bruno D, Blagden, Sarah, Willis, Anne E, Bushell, Martin
Publicado 2020

The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1)

por Farooq, Zeenat, Kusuma, Fedho, Burke, Phillip, Dufour, Catherine R., Lee, Duckgue, Tabatabaei, Negar, Toboz, Phoenix, Radovani, Ernest, Greenblatt, Jack F., Rehman, Jalees, Class, Jacob, Khoutorsky, Arkady, Fonseca, Bruno D., Richner, Justin M., Mercier, Eloi, Bourque, Guillaume, Giguère, Vincent, Subramaniam, Arvind R., Han, Jaeseok, Tahmasebi, Soroush
Publicado 2022

mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1

por Jia, Jian-Jun, Lahr, Roni M, Solgaard, Michael T, Moraes, Bruno J, Pointet, Roberta, Yang, An-Dao, Celucci, Giovanna, Graber, Tyson E, Hoang, Huy-Dung, Niklaus, Marius R, Pena, Izabella A, Hollensen, Anne K, Smith, Ewan M, Chaker-Margot, Malik, Anton, Leonie, Dajadian, Christopher, Livingstone, Mark, Hearnden, Jaclyn, Wang, Xu-Dong, Yu, Yonghao, Maier, Timm, Damgaard, Christian K, Berman, Andrea J, Alain, Tommy, Fonseca, Bruno D
Publicado 2021