Structure of the Human 26S Proteasome: SUBUNIT RADIAL DISPLACEMENTS OPEN THE GATE INTO THE PROTEOLYTIC CORE

por da Fonseca, Paula C. A., Morris, Edward P.
Publicado 2008

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core

por da Fonseca, Paula C.A., Morris, Edward P.
Publicado 2015

High-resolution cryo-EM proteasome structures in drug development

por Morris, Edward P., da Fonseca, Paula C. A.
Publicado 2017

Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes

por Toste Rêgo, Ana, da Fonseca, Paula C.A.
Publicado 2019

Building a pseudo-atomic model of the anaphase-promoting complex

por Kulkarni, Kiran, Zhang, Ziguo, Chang, Leifu, Yang, Jing, da Fonseca, Paula C. A., Barford, David
Publicado 2013

Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies

por Morris, Edward P., Rivera-Calzada, Angel, da Fonseca, Paula C. A., Llorca, Oscar, Pearl, Laurence H., Spagnolo, Laura
Publicado 2011

Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor

por da Fonseca, Paula C.A., Kong, Eric H., Zhang, Ziguo, Schreiber, Anne, Williams, Mark. A., Morris, Edward P., Barford, David
Publicado 2010

3D reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout

por Hodgkinson, Julie L., Horsley, Ashley, Stabat, David, Simon, Martha, Johnson, Steven, da Fonseca, Paula C. A., Morris, Edward P., Wall, Joseph S., Lea, Susan M., Blocker, Ariel J.
Publicado 2009

Structure and function based design of Plasmodium-selective proteasome inhibitors

por Li, Hao, O'Donoghue, Anthony J., van der Linden, Wouter A., Xie, Stanley C., Yoo, Euna, Foe, Ian T., Tilley, Leann, Craik, Charles S., da Fonseca, Paula C. A., Bogyo, Matthew
Publicado 2016

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

por Stokes, Barbara H., Yoo, Euna, Murithi, James M., Luth, Madeline R., Afanasyev, Pavel, da Fonseca, Paula C. A., Winzeler, Elizabeth A., Ng, Caroline L., Bogyo, Matthew, Fidock, David A.
Publicado 2019

Modulatory effects of cAMP and PKC activation on gap junctional intercellular communication among thymic epithelial cells

por Nihei, Oscar K, Fonseca, Paula C, Rubim, Nara M, Bonavita, Andre G, Lyra, Jurandy SPO, Neves-dos-Santos, Sandra, de Carvalho, Antonio C Campos, Spray, David C, Savino, Wilson, Alves, Luiz A
Publicado 2010

Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis

por Živković, Dušan, Sanchez Dafun, Angelique, Menneteau, Thomas, Schahl, Adrien, Lise, Sandrine, Kervarrec, Christine, Toste Rêgo, Ana, da Fonseca, Paula C. A., Chavent, Matthieu, Pineau, Charles, Burlet-Schiltz, Odile, Marcoux, Julien, Bousquet, Marie-Pierre
Publicado 2022

Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome

por Deni, Ioanna, Stokes, Barbara H., Ward, Kurt E., Fairhurst, Kate J., Pasaje, Charisse Flerida A., Yeo, Tomas, Akbar, Shirin, Park, Heekuk, Muir, Ryan, Bick, Daniella S., Zhan, Wenhu, Zhang, Hao, Liu, Yi Jing, Ng, Caroline L., Kirkman, Laura A., Almaliti, Jehad, Gould, Alexandra E., Duffey, Maëlle, O'Donoghue, Anthony J., Uhlemann, Anne-Catrin, Niles, Jacquin C., da Fonseca, Paula C.A., Gerwick, William H., Lin, Gang, Bogyo, Matthew, Fidock, David A.
Publicado 2023