Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance

por Anantha, Rachel W, Simhadri, Srilatha, Foo, Tzeh Keong, Miao, Susanna, Liu, Jingmei, Shen, Zhiyuan, Ganesan, Shridar, Xia, Bing
Publicado 2017

PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response

por Simhadri, Srilatha, Vincelli, Gabriele, Huo, Yanying, Misenko, Sarah, Foo, Tzeh Keong, Ahlskog, Johanna, Sorensen, Claus S, Oakley, Gregory G, Ganesan, Shridar, Bunting, Samuel F, Xia, Bing
Publicado 2018

Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites

por Wu, Qian, Paul, Atanu, Su, Dan, Mehmood, Shahid, Foo, Tzeh Keong, Ochi, Takashi, Bunting, Emma L., Xia, Bing, Robinson, Carol V., Wang, Bin, Blundell, Tom L.
Publicado 2016

Therapeutic targeting of BRCA1 and TP53 mutant breast cancer through mutant p53 reactivation

por Na, Bing, Yu, Xin, Withers, Tracy, Gilleran, John, Yao, Ming, Foo, Tzeh Keong, Chen, Chunxia, Moore, Dirk, Lin, Yong, Kimball, S. David, Xia, Bing, Ganesan, Shridar, Carpizo, Darren R.
Publicado 2019

Functional characterization of 84 PALB2 variants of uncertain significance

por Wiltshire, Timothy, Ducy, Mandy, Foo, Tzeh Keong, Hu, Chunling, Lee, Kun Y., Belur Nagaraj, Anil, Rodrigue, Amélie, Gomes, Thiago T., Simard, Jacques, Monteiro, Alvaro N. A., Xia, Bing, Carvalho, Marcelo A., Masson, Jean-Yves, Couch, Fergus J.
Publicado 2019

BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage

por Kang, Zhihua, Fu, Pan, Alcivar, Allen L., Fu, Haiqing, Redon, Christophe, Foo, Tzeh Keong, Zuo, Yamei, Ye, Caiyong, Baxley, Ryan, Madireddy, Advaitha, Buisson, Remi, Bielinsky, Anja-Katrin, Zou, Lee, Shen, Zhiyuan, Aladjem, Mirit I., Xia, Bing
Publicado 2021

Compromised BRCA1-PALB2 interaction is associated with breast cancer risk

por Foo, Tzeh Keong, Tischkowitz, Marc, Simhadri, Srilatha, Boshari, Talia, Zayed, Nadia, Burke, Kathleen A., Berman, Samuel H., Blecua, Pedro, Riaz, Nadeem, Huo, Yanying, Ding, Yuan Chun, Neuhausen, Susan L., Weigelt, Britta, Reis-Filho, Jorge S., Foulkes, William D., Xia, Bing
Publicado 2017

BRCA1 frameshift variants leading to extended incorrect protein C termini

por Nepomuceno, Thales C., Foo, Tzeh Keong, Richardson, Marcy E., Ranola, John Michael O., Weyandt, Jamie, Varga, Matthew J., Alarcon, Amaya, Gutierrez, Diana, von Wachenfeldt, Anna, Eriksson, Daniel, Kim, Raymond, Armel, Susan, Iversen, Edwin, Couch, Fergus J., Borg, Åke, Xia, Bing, Carvalho, Marcelo A., Monteiro, Alvaro N.A.
Publicado 2023