Biological and Clinical Insight from Analysis of the Tumor B-Cell Receptor Structure and Function in Chronic Lymphocytic Leukemia

por Forconi, Francesco, Lanham, Stuart A., Chiodin, Giorgia
Publicado 2022

Variant B Cell Receptor Isotype Functions Differ in Hairy Cell Leukemia with Mutated BRAF and IGHV Genes

por Weston-Bell, Nicola J., Forconi, Francesco, Kluin-Nelemans, Hanneke C., Sahota, Surinder S.
Publicado 2014

Selinexor Enhances NK Cell Activation Against Malignant B Cells via Downregulation of HLA-E

por Fisher, Jack G., Walker, Christopher J., Doyle, Amber DP., Johnson, Peter WM., Forconi, Francesco, Cragg, Mark S., Landesman, Yosef, Khakoo, Salim. I., Blunt, Matthew D.
Publicado 2021

PB2296: ROBUST BRUTON’S TYROSINE KINASE (BTK) DEGRADATION WITH NX-5948, AN ORAL BTK DEGRADER, IN A FIRST-IN-HUMAN PHASE 1A TRIAL IN PATIENTS (PTS) WITH RELAPSED/REFRACTORY B CELL M...

por Linton, Kim, Forconi, Francesco, Lewis, David, Riches, John, El-Sharkawi, Dima, Gleeson, Mary, Injac, Sarah G, Nandakumar, Srinand, Tan, May, Cherala, Ganesh, Collins, Graham P
Publicado 2023

Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells

por Wilmore, Sarah, Rogers-Broadway, Karly-Rai, Taylor, Joe, Lemm, Elizabeth, Fell, Rachel, Stevenson, Freda K., Forconi, Francesco, Steele, Andrew J., Coldwell, Mark, Packham, Graham, Yeomans, Alison
Publicado 2021

PB2331: AN ONGOING FIRST-IN-HUMAN PHASE 1 TRIAL OF NX-5948, AN ORAL BRUTON’S TYROSINE KINASE (BTK) DEGRADER, IN PATIENTS WITH RELAPSED/REFRACTORY B CELL MALIGNANCIES

por Linton, Kim, Doorduijn, Jeanette, El-Sharkawi, Dima, Mous, Rogier, Forconi, Francesco, Lewis, David, Gleeson, Mary, Riches, John, Mckay, Pam, Stevens, Wendy, Injac, Sarah G, Collins, Graham P
Publicado 2023

Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance

por Dal-Bo, Michele, Bertoni, Francesco, Forconi, Francesco, Zucchetto, Antonella, Bomben, Riccardo, Marasca, Roberto, Deaglio, Silvia, Laurenti, Luca, Efremov, Dimitar G, Gaidano, Gianluca, Del Poeta, Giovanni, Gattei, Valter
Publicado 2009

Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia

por Wang, Jiguang, Khiabanian, Hossein, Rossi, Davide, Fabbri, Giulia, Gattei, Valter, Forconi, Francesco, Laurenti, Luca, Marasca, Roberto, Del Poeta, Giovanni, Foà, Robin, Pasqualucci, Laura, Gaidano, Gianluca, Rabadan, Raul
Publicado 2014

DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity

por Valle-Argos, Beatriz, Chiodin, Giorgia, Bryant, Dean J., Taylor, Joe, Lemm, Elizabeth, Duriez, Patrick J., Rock, Philip J., Strefford, Jonathan C., Forconi, Francesco, Burack, Richard W., Packham, Graham, Stevenson, Freda K.
Publicado 2021

IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic...

por Bulian, Pietro, Rossi, Davide, Forconi, Francesco, Del Poeta, Giovanni, Bertoni, Francesco, Zucca, Emanuele, Montillo, Marco, Pozzato, Gabriele, D'Arena, Giovanni, Efremov, Dimitar G, Marasca, Roberto, Lauria, Francesco, Gaidano, Gianluca, Gattei, Valter, Laurenti, Luca
Publicado 2012

B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells

por Minton, Annabel R., Smith, Lindsay D., Bryant, Dean J., Strefford, Jonathan C., Forconi, Francesco, Stevenson, Freda K., Tumbarello, David A., James, Edd, Løset, Geir Åge, Munthe, Ludvig A., Steele, Andrew J., Packham, Graham
Publicado 2022

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

por Bryant, Dean, Smith, Lindsay, Rogers-Broadway, Karly Rai, Karydis, Laura, Woo, Jeongmin, Blunt, Matthew D., Forconi, Francesco, Stevenson, Freda K., Goodnow, Christopher, Russell, Amanda, Humburg, Peter, Packham, Graham, Steele, Andrew J., Strefford, Jonathan C.
Publicado 2023

B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells

por Taylor, Joe, Wilmore, Sarah, Marriot, Sophie, Rogers-Broadway, Karly-Rai, Fell, Rachel, Minton, Annabel R., Branch, Tom, Ashton-Key, Meg, Coldwell, Mark, Stevenson, Freda K., Forconi, Francesco, Steele, Andrew J., Packham, Graham, Yeomans, Alison
Publicado 2022

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia...

por Yeomans, Alison, Lemm, Elizabeth, Wilmore, Sarah, Cavell, Breeze E., Valle-Argos, Beatriz, Krysov, Sergey, Hidalgo, Marina Sanchez, Leonard, Elodie, Willis, Anne E., Forconi, Francesco, Stevenson, Freda K., Steele, Andrew J., Coldwell, Mark J., Packham, Graham
Publicado 2016

The Hydropathy Index of the HCDR3 Region of the B-Cell Receptor Identifies Two Subgroups of IGHV-Mutated Chronic Lymphocytic Leukemia Patients With Distinct Outcome

por Rodríguez-Caballero, Arancha, Fuentes Herrero, Blanca, Oliva Ariza, Guillermo, Criado, Ignacio, Alcoceba, Miguel, Prieto, Carlos, Pérez Caro, María, García-Montero, Andrés C., González Díaz, Marcos, Forconi, Francesco, Sarmento-Ribeiro, Ana Bela, Almeida, Julia, Orfao, Alberto
Publicado 2021

Endothelin-1 Promotes Survival and Chemoresistance in Chronic Lymphocytic Leukemia B Cells through ET(A) Receptor

por Maffei, Rossana, Bulgarelli, Jenny, Fiorcari, Stefania, Martinelli, Silvia, Castelli, Ilaria, Valenti, Vanessa, Rossi, Davide, Bonacorsi, Goretta, Zucchini, Patrizia, Potenza, Leonardo, Vallisa, Daniele, Gattei, Valter, Poeta, Giovanni Del, Forconi, Francesco, Gaidano, Gianluca, Narni, Franco, Luppi, Mario, Marasca, Roberto
Publicado 2014

XPO1 inhibition sensitises CLL cells to NK cell mediated cytotoxicity and overcomes HLA-E expression

por Fisher, Jack G., Doyle, Amber D. P., Graham, Lara V., Sonar, Shreyanshi, Sale, Ben, Henderson, Isla, Del Rio, Luis, Johnson, Peter W. M., Landesman, Yosef, Cragg, Mark S., Forconi, Francesco, Walker, Christopher J., Khakoo, Salim. I., Blunt, Matthew D.
Publicado 2023

Ibrutinib Plus Venetoclax in Relapsed/Refractory Chronic Lymphocytic Leukemia: The CLARITY Study

por Hillmen, Peter, Rawstron, Andy C., Brock, Kristian, Muñoz-Vicente, Samuel, Yates, Francesca J., Bishop, Rebecca, Boucher, Rebecca, MacDonald, Donald, Fegan, Christopher, McCaig, Alison, Schuh, Anna, Pettitt, Andrew, Gribben, John G., Patten, Piers E.M., Devereux, Stephen, Bloor, Adrian, Fox, Christopher P., Forconi, Francesco, Munir, Talha
Publicado 2019

Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells

por Linley, Adam J., Karydis, Laura I., Mondru, Anil K., D'Avola, Annalisa, Al Shmrany, Humood, Cicconi, Silvia, Griffin, Rebecca, Forconi, Francesco, Pettitt, Andrew R., Kalakonda, Nagesh, Rawstron, Andrew C., Hillmen, Peter, Steele, Andrew J., MacEwan, David J., Packham, Graham, Prior, Ian A., Slupsky, Joseph R.
Publicado 2021

High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL

por Chiodin, Giorgia, Drennan, Samantha, Martino, Enrica A., Ondrisova, Laura, Henderson, Isla, del Rio, Luis, Tracy, Ian, D’Avola, Annalisa, Parker, Helen, Bonfiglio, Silvia, Scarfò, Lydia, Sutton, Lesley-Ann, Strefford, Jonathan C., Forster, Jade, Brake, Oliver, Potter, Kathleen N., Sale, Benjamin, Lanham, Stuart, Mraz, Marek, Ghia, Paolo, Stevenson, Freda K., Forconi, Francesco
Publicado 2022