Aberrant spindle dynamics and cytokinesis in Dictyostelium discoideum cells that lack glycogen synthase kinase 3()

por Harwood, Adrian J., Forde-Thomas, Josephine E., Williams, Hazel, Samereier, Matthias, Müller-Taubenberger, Annette
Publicado 2013

Using ChEMBL to Complement Schistosome Drug Discovery

por Padalino, Gilda, Coghlan, Avril, Pagliuca, Giampaolo, Forde-Thomas, Josephine E., Berriman, Matthew, Hoffmann, Karl F.
Publicado 2023

Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal

por Whiteland, Helen, Crusco, Alessandra, Bloemberg, Lisa W., Tibble-Howlings, Jamie, Forde-Thomas, Josephine, Coghlan, Avril, Murphy, Patrick J., Hoffmann, Karl F.
Publicado 2020

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

por Whatley, Kezia C. L., Padalino, Gilda, Whiteland, Helen, Geyer, Kathrin K., Hulme, Benjamin J., Chalmers, Iain W., Forde-Thomas, Josephine, Ferla, Salvatore, Brancale, Andrea, Hoffmann, Karl F.
Publicado 2019

Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae

por Gasan, Thomas A., Kuipers, Marije E., Roberts, Grisial H., Padalino, Gilda, Forde-Thomas, Josephine E., Wilson, Shona, Wawrzyniak, Jakub, Tukahebwa, Edridah M., Hoffmann, Karl F., Chalmers, Iain W.
Publicado 2021

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes

por Padalino, Gilda, Celatka, Cassandra A., Rienhoff Jr., Hugh Y., Kalin, Jay H., Cole, Philip A., Lassalle, Damien, Forde-Thomas, Josephine, Chalmers, Iain W., Brancale, Andrea, Grunau, Christoph, Hoffmann, Karl F.
Publicado 2023

An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistoso...

por Whiteland, Helen L., Chakroborty, Anand, Forde-Thomas, Josephine E., Crusco, Alessandra, Cookson, Alan, Hollinshead, Jackie, Fenn, Caroline A., Bartholomew, Barbara, Holdsworth, Peter A., Fisher, Maggie, Nash, Robert J., Hoffmann, Karl F.
Publicado 2018

Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function

por Perally, Samirah, Geyer, Kathrin K., Farani, Priscila S.G., Chalmers, Iain W., Fernandez-Fuentes, Narcis, Maskell, Daniel R., Hulme, Benjamin J., Forde-Thomas, Josephine, Phillips, Dylan, Farias, Leonardo P., Collins, James J., Hoffmann, Karl F.
Publicado 2021

Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

por Hulme, Benjamin J., Geyer, Kathrin K., Forde-Thomas, Josephine E., Padalino, Gilda, Phillips, Dylan W., Ittiprasert, Wannaporn, Karinshak, Shannon E., Mann, Victoria H., Chalmers, Iain W., Brindley, Paul J., Hokke, Cornelis H., Hoffmann, Karl F.
Publicado 2022

Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica

por Chakroborty, Anand, Pritchard, Deiniol R., Bouillon, Marc E., Cervi, Anna, Kraehenbuehl, Rolf, Wild, Charlotte, Fenn, Caroline, Holdsworth, Peter, Capner, Colin, Padalino, Gilda, Forde-Thomas, Josephine E., Payne, Joseph, Smith, Brendan G., Fisher, Maggie, Lahmann, Martina, Baird, Mark S., Hoffmann, Karl F.
Publicado 2023

Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation

por Padalino, Gilda, El-Sakkary, Nelly, Liu, Lawrence J., Liu, Chenxi, Harte, Danielle S.G., Barnes, Rachel E., Sayers, Edward, Forde-Thomas, Josephine, Whiteland, Helen, Bassetto, Marcella, Ferla, Salvatore, Johnson, George, Jones, Arwyn T., Caffrey, Conor R., Chalmers, Iain, Brancale, Andrea, Hoffmann, Karl F.
Publicado 2021

Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus...

por Partridge, Frederick A., Bataille, Carole J.R., Forman, Ruth, Marriott, Amy E., Forde-Thomas, Josephine, Häberli, Cécile, Dinsdale, Ria L., O’Sullivan, James D.B., Willis, Nicky J., Wynne, Graham M., Whiteland, Helen, Archer, John, Steven, Andrew, Keiser, Jennifer, Turner, Joseph D., Hoffmann, Karl F., Taylor, Mark J., Else, Kathryn J., Russell, Angela J., Sattelle, David B.
Publicado 2021