Aspergillus fumigatus Drives Tissue Damage via Iterative Assaults upon Mucosal Integrity and Immune Homeostasis

por Okaa, Uju Joy, Bertuzzi, Margherita, Fortune-Grant, Rachael, Thomson, Darren D., Moyes, David L., Naglik, Julian R., Bignell, Elaine
Publicado 2023

Distinct Cohorts of Aspergillus fumigatus Transcription Factors Are Required for Epithelial Damage Occurring via Contact- or Soluble Effector-Mediated Mechanisms

por Rahman, Sayema, van Rhijn, Norman, Papastamoulis, Panagiotis, Thomson, Darren D., Carter, Zorana, Fortune-Grant, Rachael, Rattray, Magnus, Bromley, Michael John, Bignell, Elaine
Publicado 2022

Targeting Methionine Synthase in a Fungal Pathogen Causes a Metabolic Imbalance That Impacts Cell Energetics, Growth, and Virulence

por Scott, Jennifer, Sueiro-Olivares, Monica, Thornton, Benjamin P., Owens, Rebecca A., Muhamadali, Howbeer, Fortune-Grant, Rachael, Thomson, Darren, Thomas, Riba, Hollywood, Katherine, Doyle, Sean, Goodacre, Royston, Tabernero, Lydia, Bignell, Elaine, Amich, Jorge
Publicado 2020

Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response

por Sueiro-Olivares, Monica, Scott, Jennifer, Gago, Sara, Petrovic, Dunja, Kouroussis, Emilia, Zivanovic, Jasmina, Yu, Yidong, Strobel, Marlene, Cunha, Cristina, Thomson, Darren, Fortune-Grant, Rachael, Thusek, Sina, Bowyer, Paul, Beilhack, Andreas, Carvalho, Agostinho, Bignell, Elaine, Filipovic, Milos R., Amich, Jorge
Publicado 2021

Functional analysis of the Aspergillus fumigatus kinome reveals a DYRK kinase involved in septal plugging is a novel antifungal drug target

por van Rhijn, Norman, Zhao, Can, Al-Furaji, Narjes, Storer, Isabelle, Valero, Clara, Gago, Sara, Chown, Harry, Baldin, Clara, Fortune-Grant, Rachael, Shuraym, Hajer Bin, Ivanova, Lia, Kniemeyer, Olaf, Krüger, Thomas, Bignell, Elaine, Goldman, Gustavo, Amich, Jorge, Delneri, Daniela, Bowyer, Paul, Brakhage, Axel, Haas, Hubertus, Bromley, Michael
Publicado 2023

The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus

por Furukawa, Takanori, van Rhijn, Norman, Fraczek, Marcin, Gsaller, Fabio, Davies, Emma, Carr, Paul, Gago, Sara, Fortune-Grant, Rachael, Rahman, Sayema, Gilsenan, Jane Mabey, Houlder, Emma, Kowalski, Caitlin H., Raj, Shriya, Paul, Sanjoy, Cook, Peter, Parker, Josie E., Kelly, Steve, Cramer, Robert A., Latgé, Jean-Paul, Moye-Rowley, Scott, Bignell, Elaine, Bowyer, Paul, Bromley, Michael J.
Publicado 2020