Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an an...

por Figueroa, Isabel, Leipold, Doug, Leong, Steve, Zheng, Bing, Triguero-Carrasco, Montserrat, Fourie-O'Donohue, Aimee, Kozak, Katherine R., Xu, Keyang, Schutten, Melissa, Wang, Hong, Polson, Andrew G., Kamath, Amrita V.
Publicado 2018

Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer

por Boswell, C. Andrew, Yadav, Daniela Bumbaca, Mundo, Eduardo E., Yu, Shang-Fan, Lacap, Jennifer Arca, Fourie-O’Donohue, Aimee, Kozak, Katherine R., Ferl, Gregory Z., Zhang, Crystal, Ho, Jason, Ulufatu, Sheila, Khawli, Leslie A., Lin, Kedan
Publicado 2019

Improved translation of stability for conjugated antibodies using an in vitro whole blood assay

por Fourie-O’Donohue, Aimee, Chu, Phillip Y., dela Cruz Chuh, Josefa, Tchelepi, Robert, Tsai, Siao Ping, Tran, John C., Sawyer, William S., Su, Dian, Ng, Carl, Xu, Keyang, Yu, Shang-Fan, Pillow, Thomas H., Sadowsky, Jack, Dragovich, Peter S., Liu, Yichin, Kozak, Katherine R.
Publicado 2020