A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -β/δ, -γ, and RXR antagonists and by norbixin

por Fontaine, Valérie, Fournié, Mylène, Monteiro, Elodie, Boumedine, Thinhinane, Balducci, Christine, Guibout, Louis, Latil, Mathilde, Sahel, José-Alain, Veillet, Stanislas, Dilda, Pierre J., Lafont, René, Camelo, Serge
Publicado 2021

Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models...

por Fontaine, Valérie, Monteiro, Elodie, Fournié, Mylène, Brazhnikova, Elena, Boumedine, Thinhinane, Vidal, Cécile, Balducci, Christine, Guibout, Louis, Latil, Mathilde, Dilda, Pierre J., Veillet, Stanislas, Sahel, José-Alain, Lafont, René, Camelo, Serge
Publicado 2020

Anti-Inflammatory Effects and Photo- and Neuro-Protective Properties of BIO203, a New Amide Conjugate of Norbixin, in Development for the Treatment of Age-Related Macular Degenerat...

por Fontaine, Valérie, Balducci, Christine, Dinan, Laurence, Monteiro, Elodie, Boumedine, Thinhinane, Fournié, Mylène, Nguyen, Vincent, Guibout, Louis, Clatot, Justine, Latil, Mathilde, Veillet, Stanislas, Sahel, José-Alain, Lafont, René, Dilda, Pierre J., Camelo, Serge
Publicado 2023