Structural and Functional Determinants of γ-Secretase, an Intramembrane Protease Implicated in Alzheimer’s Disease

por Fraering, Patrick C
Publicado 2007

Gene Expression Profiling in Cells with Enhanced γ-Secretase Activity

por Magold, Alexandra I., Cacquevel, Matthias, Fraering, Patrick C.
Publicado 2009

Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes

por Cacquevel, Matthias, Aeschbach, Lorène, Houacine, Jemila, Fraering, Patrick C.
Publicado 2012

Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase

por Lemmin, Thomas, Dimitrov, Mitko, Fraering, Patrick C., Dal Peraro, Matteo
Publicado 2014

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer’s disease amyloid-β peptides

por Lei, Xiling, Yu, Jing, Niu, Qi, Liu, Jianhua, Fraering, Patrick C., Wu, Fang
Publicado 2015

Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons

por Borcel, Erika, Palczynska, Magda, Krzisch, Marine, Dimitrov, Mitko, Ulrich, Giorgio, Toni, Nicolas, Fraering, Patrick C.
Publicado 2016

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain

por Mosser, Sebastien, Alattia, Jean-René, Dimitrov, Mitko, Matz, Alexandre, Pascual, Justine, Schneider, Bernard L., Fraering, Patrick C.
Publicado 2015

Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells

por Lu, Yinzhong, Wan, Jun, Yang, Zhifeng, Lei, Xiling, Niu, Qi, Jiang, Lanxin, Passtoors, Willemijn M., Zang, Aiping, Fraering, Patrick C., Wu, Fang
Publicado 2017

The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease

por Gerber, Hermeto, Mosser, Sebastien, Boury-Jamot, Benjamin, Stumpe, Michael, Piersigilli, Alessandra, Goepfert, Christine, Dengjel, Joern, Albrecht, Urs, Magara, Fulvio, Fraering, Patrick C.
Publicado 2019

Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells

por Filipović, Aleksandra, Lombardo, Ylenia, Fronato, Monica, Abrahams, Joel, Aboagye, Eric, Nguyen, Quang-De, d’Aqua, Barbara Borda, Ridley, Anne, Green, Andrew, Rahka, Emad, Ellis, Ian, Recchi, Chiara, Przulj, Natasa, Sarajlić, Anida, Alattia, Jean-Rene, Fraering, Patrick, Deonarain, Mahendra, Coombes, R. Charles
Publicado 2014

Erratum to: Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells

por Filipović, Aleksandra, Lombardo, Ylenia, Faronato, Monica, Abrahams, Joel, Aboagye, Eric, Nguyen, Quang-De, d’Aqua, Barbara Borda, Ridley, Anne, Green, Andrew, Rahka, Emad, Ellis, Ian, Recchi, Chiara, Przulj, Natasa, Sarajlić, Anida, Alattia, Jean-Rene, Fraering, Patrick, Deonarain, Mahendra, Coombes, R. Charles
Publicado 2014

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

por Revandkar, Ajinkya, Perciato, Maria Luna, Toso, Alberto, Alajati, Abdullah, Chen, Jingjing, Gerber, Hermeto, Dimitrov, Mitko, Rinaldi, Andrea, Delaleu, Nicolas, Pasquini, Emiliano, D'Antuono, Rocco, Pinton, Sandra, Losa, Marco, Gnetti, Letizia, Arribas, Alberto, Fraering, Patrick, Bertoni, Francesco, Nepveu, Alain, Alimonti, Andrea
Publicado 2016