A New Experimental Model for Assessing Drug Efficacy against Trypanosoma cruzi Infection Based on Highly Sensitive In Vivo Imaging

por Lewis, Michael D., Francisco, Amanda Fortes, Taylor, Martin C., Kelly, John M.
Publicado 2015

Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy

por Lewis, Michael D., Francisco, Amanda Fortes, Taylor, Martin C., Jayawardhana, Shiromani, Kelly, John M.
Publicado 2016

Biological factors that impinge on Chagas disease drug development

por FRANCISCO, AMANDA F., JAYAWARDHANA, SHIROMANI, LEWIS, MICHAEL D., TAYLOR, MARTIN C., KELLY, JOHN M.
Publicado 2017

Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease

por Francisco, Amanda Fortes, Jayawardhana, Shiromani, Taylor, Martin C., Lewis, Michael D., Kelly, John M.
Publicado 2018

The Trypanosoma cruzi Vitamin C Dependent Peroxidase Confers Protection against Oxidative Stress but Is Not a Determinant of Virulence

por Taylor, Martin C., Lewis, Michael D., Francisco, Amanda Fortes, Wilkinson, Shane R., Kelly, John M.
Publicado 2015

Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging

por Francisco, Amanda Fortes, Lewis, Michael D., Jayawardhana, Shiromani, Taylor, Martin C., Chatelain, Eric, Kelly, John M.
Publicado 2015

Imaging the development of chronic Chagas disease after oral transmission

por Lewis, Michael D., Francisco, Amanda F., Jayawardhana, Shiromani, Langston, Harry, Taylor, Martin C., Kelly, John M.
Publicado 2018

Image-Based In Vitro Screening Reveals the Trypanostatic Activity of Hydroxymethylnitrofurazone against Trypanosoma cruzi

por Scarim, Cauê Benito, Olmo, Francisco, Ferreira, Elizabeth Igne, Chin, Chung Man, Kelly, John M., Fortes Francisco, Amanda
Publicado 2021

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection

por Taylor, Martin C., Ward, Alexander, Olmo, Francisco, Jayawardhana, Shiromani, Francisco, Amanda F., Lewis, Michael D., Kelly, John M.
Publicado 2020

Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice

por Jayawardhana, Shiromani, Ward, Alexander I., Francisco, Amanda F., Lewis, Michael D., Taylor, Martin C., Kelly, John M., Olmo, Francisco
Publicado 2023

Challenges in Chagas Disease Drug Development

por Francisco, Amanda F., Jayawardhana, Shiromani, Olmo, Francisco, Lewis, Michael D., Wilkinson, Shane R., Taylor, Martin C., Kelly, John M.
Publicado 2020

Local Skin Inflammation in Cutaneous Leishmaniasis as a Source of Variable Pharmacokinetics and Therapeutic Efficacy of Liposomal Amphotericin B

por Wijnant, Gert-Jan, Van Bocxlaer, Katrien, Fortes Francisco, Amanda, Yardley, Vanessa, Harris, Andy, Alavijeh, Mo, Murdan, Sudaxshina, Croft, Simon L.
Publicado 2018

Comparing in vivo bioluminescence imaging and the Multi-Cruzi immunoassay platform to develop improved Chagas disease diagnostic procedures and biomarkers for monitoring parasitolo...

por Francisco, Amanda Fortes, Saade, Ursula, Jayawardhana, Shiromani, Pottel, Hans, Scandale, Ivan, Chatelain, Eric, Liehl, Peter, Kelly, John M., Zrein, Maan
Publicado 2022

Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection

por Lewis, Michael D, Fortes Francisco, Amanda, Taylor, Martin C, Burrell-Saward, Hollie, McLatchie, Alex P, Miles, Michael A, Kelly, John M
Publicado 2014

Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole

por Campos, Mônica C., Phelan, Jody, Francisco, Amanda F., Taylor, Martin C., Lewis, Michael D., Pain, Arnab, Clark, Taane G., Kelly, John M.
Publicado 2017

Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease

por Francisco, Amanda Fortes, Sousa, Giovane R., Vaughan, Mhairi, Langston, Harry, Khan, Archie, Jayawardhana, Shiromani, Taylor, Martin C., Lewis, Michael D., Kelly, John M.
Publicado 2023

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose

por Racané, Livio, Ptiček, Lucija, Kostrun, Sanja, Raić-Malić, Silvana, Taylor, Martin Craig, Delves, Michael, Alsford, Sam, Olmo, Francisco, Francisco, Amanda Fortes, Kelly, John M.
Publicado 2023

In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution

por Ward, Alexander I., Lewis, Michael D., Khan, Archie A., McCann, Conor J., Francisco, Amanda F., Jayawardhana, Shiromani, Taylor, Martin C., Kelly, John M.
Publicado 2020

Antimicrobial and antibiofilm activities of Casearia sylvestris extracts from distinct Brazilian biomes against Streptococcus mutans and Candida albicans

por Ribeiro, Sabrina M., Fratucelli, Érick D. O., Bueno, Paula C. P., de Castro, Marlene Kelly V., Francisco, Amanda Alcalá, Cavalheiro, Alberto José, Klein, Marlise I.
Publicado 2019

Fatal progression of experimental visceral leishmaniasis is associated with intestinal parasitism and secondary infection by commensal bacteria, and is delayed by antibiotic prophy...

por Lewis, Michael D., Paun, Andrea, Romano, Audrey, Langston, Harry, Langner, Charlotte A., Moore, Ian N., Bock, Kevin W., Francisco, Amanda Fortes, Brenchley, Jason M., Sacks, David L.
Publicado 2020