High Metabolic Dependence on Oxidative Phosphorylation Drives Sensitivity to Metformin Treatment in MLL/AF9 Acute Myeloid Leukemia

por Liu, Longlong, Patnana, Pradeep Kumar, Xie, Xiaoqing, Frank, Daria, Nimmagadda, Subbaiah Chary, Rosemann, Annegret, Liebmann, Marie, Klotz, Luisa, Opalka, Bertram, Khandanpour, Cyrus
Publicado 2022

Curcumin as an Epigenetic Therapeutic Agent in Myelodysplastic Syndromes (MDS)

por Xie, Xiaoqing, Frank, Daria, Patnana, Pradeep Kumar, Schütte, Judith, Al-Matary, Yahya, Liu, Longlong, Wei, Lanying, Dugas, Martin, Varghese, Julian, Nimmagadda, Subbaiah Chary, Khandanpour, Cyrus
Publicado 2021

Bcr-TMP, a Novel Nanomolar-Active Compound That Exhibits Both MYB- and Microtubule-Inhibitory Activity

por Yusenko, Maria V., Biyanee, Abhiruchi, Frank, Daria, Köhler, Leonhard H. F., Andersson, Mattias K., Khandanpour, Cyrus, Schobert, Rainer, Stenman, Göran, Biersack, Bernhard, Klempnauer, Karl-Heinz
Publicado 2021

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1

por Vadnais, Charles, Chen, Riyan, Fraszczak, Jennifer, Yu, Zhenbao, Boulais, Jonathan, Pinder, Jordan, Frank, Daria, Khandanpour, Cyrus, Hébert, Josée, Dellaire, Graham, Côté, Jean-François, Richard, Stéphane, Orthwein, Alexandre, Drobetsky, Elliot, Möröy, Tarik
Publicado 2018

Inhibiting PI3K–AKT–mTOR Signaling in Multiple Myeloma-Associated Mesenchymal Stem Cells Impedes the Proliferation of Multiple Myeloma Cells

por Heinemann, Luca, Möllers, Klara Maria, Ahmed, Helal Mohammed Mohammed, Wei, Lanying, Sun, Kaiyan, Nimmagadda, Subbaiah Chary, Frank, Daria, Baumann, Anja, Poos, Alexandra M., Dugas, Martin, Varghese, Julian, Raab, Marc-Steffen, Khandanpour, Cyrus
Publicado 2022

Presence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibition

por Vorwerk, Jan, Sun, Kaiyan, Frank, Daria, Neumann, Felix, Hüve, Jana, Budde, Paulina Marie, Liu, Longlong, Xie, Xiaoqing, Patnana, Pradeep Kumar, Ahmed, Helal Mohammed Mohammed, Opalka, Bertram, Lenz, Georg, Jayavelu, Ashok Kumar, Khandanpour, Cyrus
Publicado 2022

Dose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCs

por Xie, Xiaoqing, Patnana, Pradeep Kumar, Frank, Daria, Schütte, Judith, Al-Matary, Yahya, Künstner, Axel, Busch, Hauke, Ahmed, Helal, Liu, Longlong, Engel, Daniel R., Dührsen, Ulrich, Rosenbauer, Frank, Von Bubnoff, Nikolas, Lenz, Georg, Khandanpour, Cyrus
Publicado 2023

GFI1B acts as a metabolic regulator in hematopoiesis and acute myeloid leukemia

por Liu, Longlong, Patnana, Pradeep Kumar, Xie, Xiaoqing, Frank, Daria, Nimmagadda, Subbaiah Chary, Su, Minhua, Zhang, Donghua, Koenig, Thorsten, Rosenbauer, Frank, Liebmann, Marie, Klotz, Luisa, Xu, Wendan, Vorwerk, Jan, Neumann, Felix, Hüve, Jana, Unger, Andreas, Okun, Jürgen Günther, Opalka, Bertram, Khandanpour, Cyrus
Publicado 2022

Gfi1b: a key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndrome

por Thivakaran, Aniththa, Botezatu, Lacramioara, Hönes, Judith M., Schütte, Judith, Vassen, Lothar, Al-Matary, Yahya S., Patnana, Pradeep, Zeller, Amos, Heuser, Michael, Thol, Felicitas, Gabdoulline, Razif, Olberding, Nadine, Frank, Daria, Suslo, Marina, Köster, Renata, Lennartz, Klaus, Görgens, Andre, Giebel, Bernd, Opalka, Bertram, Dührsen, Ulrich, Khandanpour, Cyrus
Publicado 2018