Pyrazolopyrimide library screening in glioma cells discovers highly potent antiproliferative leads that target the PI3K/mTOR pathway

por Valero, Teresa, Baillache, Daniel J., Fraser, Craig, Myers, Samuel H., Unciti-Broceta, Asier
Publicado 2020

Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine

por Weiss, Jason T., Dawson, John C., Fraser, Craig, Rybski, Witold, Torres-Sánchez, Carmen, Bradley, Mark, Patton, E. Elizabeth, Carragher, Neil O., Unciti-Broceta, Asier
Publicado 2014

Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach

por Weiss, Jason T., Dawson, John C., Macleod, Kenneth G., Rybski, Witold, Fraser, Craig, Torres-Sánchez, Carmen, Patton, E. Elizabeth, Bradley, Mark, Carragher, Neil O., Unciti-Broceta, Asier
Publicado 2014

N-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell culture

por Weiss, Jason T., Fraser, Craig, Rubio-Ruiz, Belén, Myers, Samuel H., Crispin, Richard, Dawson, John C., Brunton, Valerie G., Patton, E. Elizabeth, Carragher, Neil O., Unciti-Broceta, Asier
Publicado 2014

Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity...

por Fraser, Craig, Dawson, John C., Dowling, Reece, Houston, Douglas R., Weiss, Jason T., Munro, Alison F., Muir, Morwenna, Harrington, Lea, Webster, Scott P., Frame, Margaret C., Brunton, Valerie G., Patton, E. Elizabeth, Carragher, Neil O., Unciti-Broceta, Asier
Publicado 2016

Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy

por Creedon, Helen, Gómez-Cuadrado, Laura, Tarnauskaitė, Žygimantė, Balla, Jozef, Canel, Marta, MacLeod, Kenneth G., Serrels, Bryan, Fraser, Craig, Unciti-Broceta, Asier, Tracey, Natasha, Le Bihan, Thierry, Klinowska, Teresa, Sims, Andrew H., Byron, Adam, Brunton, Valerie G.
Publicado 2016

A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

por Temps, Carolin, Lietha, Daniel, Webb, Emily R., Li, Xue-Feng, Dawson, John C., Muir, Morwenna, Macleod, Kenneth G., Valero, Teresa, Munro, Alison F., Contreras-Montoya, Rafael, Luque-Ortega, Juan R., Fraser, Craig, Beetham, Henry, Schoenherr, Christina, Lopalco, Maria, Arends, Mark J., Frame, Margaret C., Qian, Bin-Zhi, Brunton, Valerie G., Carragher, Neil O., Unciti-Broceta, Asier
Publicado 2021