The Link Between Tau and Insulin Signaling: Implications for Alzheimer’s Disease and Other Tauopathies

por Gonçalves, Rafaella Araujo, Wijesekara, Nadeeja, Fraser, Paul E., De Felice, Fernanda G.
Publicado 2019

Behavioral Abnormalities in Knockout and Humanized Tau Mice

por Gonçalves, Rafaella Araujo, Wijesekara, Nadeeja, Fraser, Paul E., De Felice, Fernanda G.
Publicado 2020

α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport

por Wijesekara, Nadeeja, Ahrens, Rosemary, Wu, Ling, Langman, Tammy, Tandon, Anurag, Fraser, Paul E.
Publicado 2021

SUMO1 Modification of Tau in Progressive Supranuclear Palsy

por Takamura, Hironori, Nakayama, Yoshiaki, Ito, Hidefumi, Katayama, Taiichi, Fraser, Paul E., Matsuzaki, Shinsuke
Publicado 2022

Anti-Amyloid-β-Mediated Positron Emission Tomography Imaging in Alzheimer's Disease Mouse Brains

por McLean, Daniel, Cooke, Michael J., Wang, Yuanfei, Green, David, Fraser, Paul E., George-Hyslop, Peter St, Shoichet, Molly S.
Publicado 2012

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APP(NL-F) mouse model of Alzheimer disease

por Wang, Hansen, Williams, Declan, Griffin, Jennifer, Saito, Takashi, Saido, Takaomi C., Fraser, Paul E., Rogaeva, Ekaterina, Schmitt-Ulms, Gerold
Publicado 2017

Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

por Marzban, Lucy, Tomas, Alejandra, Becker, Thomas C., Rosenberg, Lawrence, Oberholzer, Jose, Fraser, Paul E., Halban, Philippe A., Verchere, C. Bruce
Publicado 2008

Erratum. Small Interfering RNA—Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Di...

por Marzban, Lucy, Tomas, Alejandra, Becker, Thomas C., Rosenberg, Lawrence, Oberholzer, Jose, Fraser, Paul E., Halban, Philippe A., Verchere, C. Bruce
Publicado 2016

Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

por Gorman, Paul M, Kim, Sanguk, Guo, Meng, Melnyk, Roman A, McLaurin, Joanne, Fraser, Paul E, Bowie, James U, Chakrabartty, Avijit
Publicado 2008

TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage

por Pardossi-Piquard, Raphaëlle, Böhm, Christopher, Chen, Fusheng, Kanemoto, Soshi, Checler, Frédéric, Schmitt-Ulms, Gerold, St. George-Hyslop, Peter, Fraser, Paul E.
Publicado 2009

Structural biology of presenilin 1 complexes

por Li, Yi, Bohm, Christopher, Dodd, Roger, Chen, Fusheng, Qamar, Seema, Schmitt-Ulms, Gerold, Fraser, Paul E, St George-Hyslop, Peter H
Publicado 2014

Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors

por Wislet-Gendebien, Sabine, Visanji, Naomi P, Whitehead, Shawn N, Marsilio, Diana, Hou, Weimin, Figeys, Daniel, Fraser, Paul E, Bennett, Steffany AL, Tandon, Anurag
Publicado 2008

The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease

por Brautigam, Hannah, Steele, John W, Westaway, David, Fraser, Paul E, George-Hyslop, Peter H St, Gandy, Sam, Hof, Patrick R, Dickstein, Dara L
Publicado 2012

SUMO1 Affects Synaptic Function, Spine Density and Memory

por Matsuzaki, Shinsuke, Lee, Linda, Knock, Erin, Srikumar, Tharan, Sakurai, Mikako, Hazrati, Lili-Naz, Katayama, Taiichi, Staniszewski, Agnieszka, Raught, Brian, Arancio, Ottavio, Fraser, Paul E.
Publicado 2015

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease

por Verdile, Giuseppe, Keane, Kevin N., Cruzat, Vinicius F., Medic, Sandra, Sabale, Miheer, Rowles, Joanne, Wijesekara, Nadeeja, Martins, Ralph N., Fraser, Paul E., Newsholme, Philip
Publicado 2015

Longitudinal evaluation of Tau‐P301L transgenic mice reveals no cognitive impairments at 17 months of age

por Kent, Brianne A., Heath, Christopher J., Kim, Chi Hun, Ahrens, Rosemary, Fraser, Paul E., St George‐Hyslop, Peter, Bussey, Timothy J., Saksida, Lisa M.
Publicado 2017

Efficient production of a mature and functional gamma secretase protease

por Khan, Imran, Krishnaswamy, Sudarsan, Sabale, Miheer, Groth, David, Wijaya, Linda, Morici, Michael, Berger, Imre, Schaffitzel, Christiane, Fraser, Paul E., Martins, Ralph N., Verdile, Giuseppe
Publicado 2018

Retraction Note to: Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors

por Wislet-Gendebien, Sabine, Visanji, Naomi P., Whitehead, Shawn N., Marsilio, Diana, Hou, Weimin, Figeys, Daniel, Fraser, Paul E., Bennett, Steffany A. L., Tandon, Anurag
Publicado 2021

Commentary: Analysis of SUMO1-conjugation at synapses

por Wilkinson, Kevin A., Martin, Stéphane, Tyagarajan, Shiva K., Arancio, Ottavio, Craig, Tim J., Guo, Chun, Fraser, Paul E., Goldstein, Steven A. N., Henley, Jeremy M.
Publicado 2017

Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein

por Martinez-Valbuena, Ivan, Valenti-Azcarate, Rafael, Amat-Villegas, Irene, Marcilla, Irene, Marti-Andres, Gloria, Caballero, Maria-Cristina, Riverol, Mario, Tuñon, María-Teresa, Fraser, Paul E., Luquin, María-Rosario
Publicado 2021