Piecing together the FTO jigsaw

por Frayling, Timothy M, Ong, Ken
Publicado 2011

Recent progress in the use of genetics to understand links between type 2 diabetes and related metabolic traits

por Yaghootkar, Hanieh, Frayling, Timothy M
Publicado 2013

Parental diabetes and birthweight in 236 030 individuals in the UK Biobank Study

por Tyrrell, Jessica S, Yaghootkar, Hanieh, Freathy, Rachel M, Hattersley, Andrew T, Frayling, Timothy M
Publicado 2013

Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences End Points From Across the Cardiovascular Disease Spectrum Through Adult Body Size

por Power, Grace M., Tyrrell, Jessica, Frayling, Timothy M., Davey Smith, George, Richardson, Tom G.
Publicado 2021

Genetic variants in Apolipoprotein AV alter triglyceride concentrations in pregnancy

por Ward, Kirsten J, Shields, Beverley, Knight, Beatrice, Salzmann, Maurice B, Hattersley, Andrew T, Frayling, Timothy M
Publicado 2003

The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI

por Webster, Rebecca J, Warrington, Nicole M, Beilby, John P, Frayling, Timothy M, Palmer, Lyle J
Publicado 2010

Simulated distributions from negative experiments highlight the importance of the body mass index distribution in explaining depression–body mass index genetic risk score interacti...

por Casanova, Francesco, O’Loughlin, Jessica, Lewis, Cathryn, Frayling, Timothy M, Wood, Andrew R, Tyrrell, Jessica
Publicado 2022

PLIN1 Haploinsufficiency Causes a Favorable Metabolic Profile

por Patel, Kashyap A, Burman, Shivang, Laver, Thomas W, Hattersley, Andrew T, Frayling, Timothy M, Weedon, Michael N
Publicado 2022

Allelic drop-out may occur with a primer binding site polymorphism for the commonly used RFLP assay for the -1131T>C polymorphism of the Apolipoprotein AV gene

por Ward, Kirsten J, Ellard, Sian, Yajnik, Chittaranjan S, Frayling, Timothy M, Hattersley, Andrew T, Venigalla, Prathyusha NS, Chandak, Giriraj R
Publicado 2006

A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population

por Freathy, Rachel M, Mitchell, Simon MS, Knight, Beatrice, Shields, Beverley, Weedon, Michael N, Hattersley, Andrew T, Frayling, Timothy M
Publicado 2006

Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach

por Perry, John R.B., McCarthy, Mark I., Hattersley, Andrew T., Zeggini, Eleftheria, Weedon, Michael N., Frayling, Timothy M.
Publicado 2009

Influence of cell distribution and diabetes status on the association between mitochondrial DNA copy number and aging phenotypes in the InCHIANTI study

por Moore, Ann Zenobia, Ding, Jun, Tuke, Marcus A., Wood, Andrew R., Bandinelli, Stefania, Frayling, Timothy M., Ferrucci, Luigi
Publicado 2017

Rare genetic variants in genes and loci linked to dominant monogenic developmental disorders cause milder related phenotypes in the general population

por Kingdom, Rebecca, Tuke, Marcus, Wood, Andrew, Beaumont, Robin N., Frayling, Timothy M., Weedon, Michael N., Wright, Caroline F.
Publicado 2022

FTO gene variation and measures of body mass in an African population

por Hennig, Branwen J, Fulford, Anthony J, Sirugo, Giorgio, Rayco-Solon, Pura, Hattersley, Andrew T, Frayling, Timothy M, Prentice, Andrew M
Publicado 2009

A Powerful Approach to Sub-Phenotype Analysis in Population-Based Genetic Association Studies

por Morris, Andrew P, Lindgren, Cecilia M, Zeggini, Eleftheria, Timpson, Nicholas J, Frayling, Timothy M, Hattersley, Andrew T, McCarthy, Mark I
Publicado 2010

Low Frequency Variants in the Exons Only Encoding Isoform A of HNF1A Do Not Contribute to Susceptibility to Type 2 Diabetes

por Jafar-Mohammadi, Bahram, Groves, Christopher J., Owen, Katharine R., Frayling, Timothy M., Hattersley, Andrew T., McCarthy, Mark I., Gloyn, Anna L.
Publicado 2009

Quantification of the overall contribution of gene-environment interaction for obesity-related traits

por Sulc, Jonathan, Mounier, Ninon, Günther, Felix, Winkler, Thomas, Wood, Andrew R., Frayling, Timothy M., Heid, Iris M., Robinson, Matthew R., Kutalik, Zoltán
Publicado 2020

Genetic predictors of participation in optional components of UK Biobank

por Tyrrell, Jessica, Zheng, Jie, Beaumont, Robin, Hinton, Kathryn, Richardson, Tom G., Wood, Andrew R., Davey Smith, George, Frayling, Timothy M., Tilling, Kate
Publicado 2021

Age-specific effects of weight-based body size on fracture risk in later life: a lifecourse Mendelian randomisation study

por Power, Grace Marion, Tobias, Jonathan H, Frayling, Timothy M, Tyrrell, Jessica, Hartley, April E, Heron, Jon E, Davey Smith, George, Richardson, Tom G
Publicado 2023

Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk

por Lango, Hana, Palmer, Colin N.A., Morris, Andrew D., Zeggini, Eleftheria, Hattersley, Andrew T., McCarthy, Mark I., Frayling, Timothy M., Weedon, Michael N.
Publicado 2008