Two decades since the fetal insulin hypothesis: what have we learned from genetics?

por Hughes, Alice E., Hattersley, Andrew T., Flanagan, Sarah E., Freathy, Rachel M.
Publicado 2021

Parental diabetes and birthweight in 236 030 individuals in the UK Biobank Study

por Tyrrell, Jessica S, Yaghootkar, Hanieh, Freathy, Rachel M, Hattersley, Andrew T, Frayling, Timothy M
Publicado 2013

How Can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes?

por Beaumont, Robin N., Horikoshi, Momoko, McCarthy, Mark I., Freathy, Rachel M.
Publicado 2017

Using structural equation modelling to jointly estimate maternal and fetal effects on birthweight in the UK Biobank

por Warrington, Nicole M, Freathy, Rachel M, Neale, Michael C, Evans, David M
Publicado 2018

The Effect of Genetic Variation on the Placental Transcriptome in Humans

por Kikas, Triin, Rull, Kristiina, Beaumont, Robin N., Freathy, Rachel M., Laan, Maris
Publicado 2019

Common genetic variants with fetal effects on birth weight are enriched for proximity to genes implicated in rare developmental disorders

por Beaumont, Robin N, Mayne, Isabelle K, Freathy, Rachel M, Wright, Caroline F
Publicado 2021

Monogenic disease analysis establishes that fetal insulin accounts for half of human fetal growth

por Hughes, Alice E., De Franco, Elisa, Freathy, Rachel M., Flanagan, Sarah E., Hattersley, Andrew T.
Publicado 2023

Association of COMT Val(108/158)Met Genotype and Cigarette Smoking in Pregnant Women

por Munafò, Marcus R., Freathy, Rachel M., Ring, Susan M., St Pourcain, Beate, Davey Smith, George
Publicado 2011

Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight

por Hwang, Liang-Dar, Lawlor, Deborah A, Freathy, Rachel M, Evans, David M, Warrington, Nicole M
Publicado 2019

Smoking Is Associated with, but Does Not Cause, Depressed Mood in Pregnancy – A Mendelian Randomization Study

por Lewis, Sarah J., Araya, Ricardo, Davey Smith, George, Freathy, Rachel, Gunnell, David, Palmer, Tom, Munafò, Marcus
Publicado 2011

A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population

por Freathy, Rachel M, Mitchell, Simon MS, Knight, Beatrice, Shields, Beverley, Weedon, Michael N, Hattersley, Andrew T, Frayling, Timothy M
Publicado 2006

Smoking during pregnancy and its effect on placental weight: A Mendelian randomization study

por Jaitner, Annika, Vaudel, Marc, Tsaneva-Atanasova, Krasimira, Njølstad, Pål R., Jacobsson, Bo, Bowden, Jack, Johansson, Stefan, Freathy, Rachel M.
Publicado 2023

Assessing whether genetic scores explain extra variation in birthweight, when added to clinical and anthropometric measures

por Haulder, Maneka, Hughes, Alice E., Beaumont, Robin N., Knight, Bridget A., Hattersley, Andrew T., Shields, Beverley M., Freathy, Rachel M.
Publicado 2022

A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5–CHRNA3–CHRNB4) is associated with a reduced ability of women to quit smoking in pregnanc...

por Freathy, Rachel M., Ring, Susan M., Shields, Beverley, Galobardes, Bruna, Knight, Beatrice, Weedon, Michael N., Smith, George Davey, Frayling, Timothy M., Hattersley, Andrew T.
Publicado 2009

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians

por Freathy, Rachel M, Weedon, Michael N, Melzer, David, Shields, Beverley, Hitman, Graham A, Walker, Mark, McCarthy, Mark I, Hattersley, Andrew T, Frayling, Timothy M
Publicado 2006

Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: a Mendelian randomization study

por Decina, Caitlin S, Hopkins, Rhian, Bowden, Jack, Shields, Beverly M, Lawlor, Deborah A, Warrington, Nicole M, Evans, David M, Freathy, Rachel M, Beaumont, Robin N
Publicado 2022

Direct and INdirect effects analysis of Genetic lOci (DINGO): A software package to increase the power of locus discovery in GWAS meta-analyses of perinatal phenotypes and traits i...

por Hwang, Liang-Dar, Cuellar-Partida, Gabriel, Yengo, Loic, Zeng, Jian, Beaumont, Robin N., Freathy, Rachel M., Moen, Gunn-Helen, Warrington, Nicole M., Evans, David M.
Publicado 2023

Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight

por Moen, Gunn-Helen, Beaumont, Robin N, Grarup, Niels, Sommer, Christine, Shields, Beverley M, Lawlor, Deborah A, Freathy, Rachel M, Evans, David M, Warrington, Nicole M
Publicado 2020

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively

por Wood, Andrew R., Tyrrell, Jessica, Beaumont, Robin, Jones, Samuel E., Tuke, Marcus A., Ruth, Katherine S., Yaghootkar, Hanieh, Freathy, Rachel M., Murray, Anna, Frayling, Timothy M., Weedon, Michael N.
Publicado 2016

Association of maternal circulating 25(OH)D and calcium with birth weight: A mendelian randomisation analysis

por Thompson, William D., Tyrrell, Jessica, Borges, Maria-Carolina, Beaumont, Robin N., Knight, Bridget A., Wood, Andrew R., Ring, Susan M., Hattersley, Andrew T., Freathy, Rachel M., Lawlor, Debbie A.
Publicado 2019