Activation of PKC triggers rescue of NPC1 patient specific iPSC derived glial cells from gliosis

por Peter, Franziska, Rost, Sebastian, Rolfs, Arndt, Frech, Moritz J.
Publicado 2017

Impact of Reduced Cerebellar EAAT Expression on Purkinje Cell Firing Pattern of NPC1-deficient Mice

por Rabenstein, Michael, Peter, Franziska, Rolfs, Arndt, Frech, Moritz J.
Publicado 2018

Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Niemann-Pick Type C1

por Völkner, Christin, Liedtke, Maik, Hermann, Andreas, Frech, Moritz J.
Publicado 2021

Impact of Organelle Transport Deficits on Mitophagy and Autophagy in Niemann–Pick Disease Type C

por Liedtke, Maik, Völkner, Christin, Hermann, Andreas, Frech, Moritz J.
Publicado 2022

Cyclodextrin Alters GABAergic Input to CA1 Pyramidal Cells in Wild-Type But Not in NPC1-Deficient Mice

por Frech, Moritz J., Rabenstein, Michael, Bovensiepen, Katja, Rost, Sebastian, Rolfs, Arndt
Publicado 2015

Dataset in support of the generation of Niemann-Pick disease Type C1 patient-specific iPS cell lines carrying the novel NPC1 mutation c.1180T>C or the prevalent c.3182T>C mutation...

por Peter, Franziska, Trilck, Michaela, Rabenstein, Michael, Rolfs, Arndt, Frech, Moritz J.
Publicado 2017

Alteration of GABAergic Input Precedes Neurodegeneration of Cerebellar Purkinje Cells of NPC1-Deficient Mice

por Rabenstein, Michael, Murr, Nico, Hermann, Andreas, Rolfs, Arndt, Frech, Moritz J.
Publicado 2019

Patient-Specific iPSC-Derived Neural Differentiated and Hepatocyte-like Cells, Carrying the Compound Heterozygous Mutation p.V1023Sfs*15/p.G992R, Present the “Variant” Biochemical...

por Völkner, Christin, Liedtke, Maik, Untucht, Robert, Hermann, Andreas, Frech, Moritz J.
Publicado 2021

Differentiation of Human Neural Progenitor Cells in Functionalized Hydrogel Matrices

por Liedmann, Andrea, Frech, Stefanie, Morgan, Peter J., Rolfs, Arndt, Frech, Moritz J.
Publicado 2012

Niemann-Pick type C1 patient-specific induced pluripotent stem cells display disease specific hallmarks

por Trilck, Michaela, Hübner, Rayk, Seibler, Philip, Klein, Christine, Rolfs, Arndt, Frech, Moritz J
Publicado 2013

Assessment of FDA-Approved Drugs as a Therapeutic Approach for Niemann-Pick Disease Type C1 Using Patient-Specific iPSC-Based Model Systems

por Völkner, Christin, Pantoom, Supansa, Liedtke, Maik, Lukas, Jan, Hermann, Andreas, Frech, Moritz J.
Publicado 2022

Oxidative Stress and Alterations in the Antioxidative Defense System in Neuronal Cells Derived from NPC1 Patient-Specific Induced Pluripotent Stem Cells

por Jürs, Alexandra V., Völkner, Christin, Liedtke, Maik, Huth, Katharina, Lukas, Jan, Hermann, Andreas, Frech, Moritz J.
Publicado 2020

Pathophysiological In Vitro Profile of Neuronal Differentiated Cells Derived from Niemann-Pick Disease Type C2 Patient-Specific iPSCs Carrying the NPC2 Mutations c.58G>T/c.140G>T

por Liedtke, Maik, Völkner, Christin, Jürs, Alexandra V., Peter, Franziska, Rabenstein, Michael, Hermann, Andreas, Frech, Moritz J.
Publicado 2021

Erythropoietin and the effect of oxygen during proliferation and differentiation of human neural progenitor cells

por Giese, Anne-Katrin, Frahm, Jana, Hübner, Rayk, Luo, Jiankai, Wree, Andreas, Frech, Moritz J, Rolfs, Arndt, Ortinau, Stefanie
Publicado 2010

Effect of 3D-scaffold formation on differentiation and survival in human neural progenitor cells

por Ortinau, Stefanie, Schmich, Jürgen, Block, Stephan, Liedmann, Andrea, Jonas, Ludwig, Weiss, Dieter G, Helm, Christiane A, Rolfs, Arndt, Frech, Moritz J
Publicado 2010

The novel arylindolylmaleimide PDA-66 displays pronounced antiproliferative effects in acute lymphoblastic leukemia cells

por Kretzschmar, Christin, Roolf, Catrin, Langhammer, Tina-Susann, Sekora, Anett, Pews-Davtyan, Anahit, Beller, Matthias, Frech, Moritz J, Eisenlöffel, Christian, Rolfs, Arndt, Junghanss, Christian
Publicado 2014

Quantitative and kinetic profile of Wnt/β-catenin signaling components during human neural progenitor cell differentiation

por Mazemondet, Orianne, Hubner, Rayk, Frahm, Jana, Koczan, Dirk, Bader, Benjamin M., Weiss, Dieter G., Uhrmacher, Adelinde M., Frech, Moritz J., Rolfs, Arndt, Luo, Jiankai
Publicado 2011

Determination of the Pathological Features of NPC1 Variants in a Cellular Complementation Test

por Feng, Xiao, Cozma, Claudia, Pantoom, Supansa, Hund, Christina, Iwanov, Katharina, Petters, Janine, Völkner, Christin, Bauer, Claudia, Vogel, Florian, Bauer, Peter, Weiss, Frank U., Lerch, Markus M., Knospe, Anne-Marie, Hermann, Andreas, Frech, Moritz J., Luo, Jiankai, Rolfs, Arndt, Lukas, Jan
Publicado 2019

Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism

por Gläser, Anne, Hammerl, Franziska, Gräler, Markus H., Coldewey, Sina M., Völkner, Christin, Frech, Moritz J., Yang, Fan, Luo, Jiankai, Tönnies, Eric, von Bohlen und Halbach, Oliver, Brandt, Nicola, Heimes, Diana, Neßlauer, Anna-Maria, Korenke, Georg Christoph, Owczarek-Lipska, Marta, Neidhardt, John, Rolfs, Arndt, Wree, Andreas, Witt, Martin, Bräuer, Anja Ursula
Publicado 2020