It’s Complicated: Lung Dendritic Cells in Chronic Obstructive Pulmonary Disease

por Freeman, Christine M., Curtis, Jeffrey L.
Publicado 2020

Finding the Right Biological: Eosinophil Subset Differences in Asthma and Chronic Obstructive Pulmonary Disease

por Freeman, Christine M., Curtis, Jeffrey L., Hastie, Annette T.
Publicado 2023

Bacterial Topography of the Healthy Human Lower Respiratory Tract

por Dickson, Robert P., Erb-Downward, John R., Freeman, Christine M., McCloskey, Lisa, Falkowski, Nicole R., Huffnagle, Gary B., Curtis, Jeffrey L.
Publicado 2017

Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripher...

por Freeman, Christine M., Martinez, Carlos H., Todt, Jill C., Martinez, Fernando J., Han, MeiLan K., Thompson, Deborah L., McCloskey, Lisa, Curtis, Jeffrey L.
Publicado 2015

PGE(2) accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking

por Penke, Loka R, Speth, Jennifer M, Draijer, Christina, Zaslona, Zbigniew, Chen, Judy, Mancuso, Peter, Freeman, Christine M, Curtis, Jeffrey L, Goldstein, Daniel R, Peters-Golden, Marc
Publicado 2020

Human lung cDC1 drive increased perforin-mediated NK cytotoxicity in chronic obstructive pulmonary disease

por Pallazola, Alexander M., Rao, Jessica X., Mengistu, Dawit T., Morcos, Maria S., Toma, Mariam S., Stolberg, Valerie R., Tretyakova, Alexandra, McCloskey, Lisa, Curtis, Jeffrey L., Freeman, Christine M.
Publicado 2021

Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals

por Bassis, Christine M., Erb-Downward, John R., Dickson, Robert P., Freeman, Christine M., Schmidt, Thomas M., Young, Vincent B., Beck, James M., Curtis, Jeffrey L., Huffnagle, Gary B.
Publicado 2015

Changes in the Lung Microbiome following Lung Transplantation Include the Emergence of Two Distinct Pseudomonas Species with Distinct Clinical Associations

por Dickson, Robert P., Erb-Downward, John R., Freeman, Christine M., Walker, Natalie, Scales, Brittan S., Beck, James M., Martinez, Fernando J., Curtis, Jeffrey L., Lama, Vibha N., Huffnagle, Gary B.
Publicado 2014

Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression

por Todt, Jill C, Freeman, Christine M, Brown, Jeanette P, Sonstein, Joanne, Ames, Theresa M, McCubbrey, Alexandra L, Martinez, Fernando J, Chensue, Stephen W, Beck, James M, Curtis, Jeffrey L
Publicado 2013

Human CD56+ Cytotoxic Lung Lymphocytes Kill Autologous Lung Cells in Chronic Obstructive Pulmonary Disease

por Freeman, Christine M., Stolberg, Valerie R., Crudgington, Sean, Martinez, Fernando J., Han, MeiLan K., Chensue, Stephen W., Arenberg, Douglas A., Meldrum, Catherine A., McCloskey, Lisa, Curtis, Jeffrey L.
Publicado 2014

Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling

por Bourdonnay, Emilie, Zasłona, Zbigniew, Penke, Loka Raghu Kumar, Speth, Jennifer M., Schneider, Daniel J., Przybranowski, Sally, Swanson, Joel A., Mancuso, Peter, Freeman, Christine M., Curtis, Jeffrey L., Peters-Golden, Marc
Publicado 2015

Lung CD8+ T cells in COPD have increased expression of bacterial TLRs

por Freeman, Christine M, Martinez, Fernando J, Han, MeiLan K, Washko,, George R, McCubbrey, Alexandra L, Chensue, Stephen W, Arenberg, Douglas A, Meldrum, Catherine A, McCloskey, Lisa, Curtis, Jeffrey L
Publicado 2013

Analysis of the Lung Microbiome in the “Healthy” Smoker and in COPD

por Erb-Downward, John R., Thompson, Deborah L., Han, Meilan K., Freeman, Christine M., McCloskey, Lisa, Schmidt, Lindsay A., Young, Vincent B., Toews, Galen B., Curtis, Jeffrey L., Sundaram, Baskaran, Martinez, Fernando J., Huffnagle, Gary B.
Publicado 2011

Basal Gene Expression by Lung CD4+ T Cells in Chronic Obstructive Pulmonary Disease Identifies Independent Molecular Correlates of Airflow Obstruction and Emphysema Extent

por Freeman, Christine M., McCubbrey, Alexandra L., Crudgington, Sean, Nelson, Joshua, Martinez, Fernando J., Han, MeiLan K., Washko, George R., Chensue, Stephen W., Arenberg, Douglas A., Meldrum, Catherine A., McCloskey, Lisa, Curtis, Jeffrey L.
Publicado 2014

Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report

por Tighe, Robert M., Redente, Elizabeth F., Yu, Yen-Rei, Herold, Susanne, Sperling, Anne I., Curtis, Jeffrey L., Duggan, Ryan, Swaminathan, Suchitra, Nakano, Hideki, Zacharias, William J., Janssen, William J., Freeman, Christine M., Brinkman, Ryan R., Singer, Benjamin D., Jakubzick, Claudia V.
Publicado 2019

GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease

por Martinez, Carlos H., Freeman, Christine M., Nelson, Joshua D., Murray, Susan, Wang, Xin, Budoff, Matthew J., Dransfield, Mark T., Hokanson, John E., Kazerooni, Ella A., Kinney, Gregory L., Regan, Elizabeth A., Wells, J. Michael, Martinez, Fernando J., Han, MeiLan K., Curtis, Jeffrey L.
Publicado 2017

Critical Relevance of Stochastic Effects on Low-Bacterial-Biomass 16S rRNA Gene Analysis

por Erb-Downward, John R., Falkowski, Nicole R., D’Souza, Jennifer C., McCloskey, Lisa M., McDonald, Roderick A., Brown, Christopher A., Shedden, Kerby, Dickson, Robert P., Freeman, Christine M., Stringer, Kathleen A., Foxman, Betsy, Huffnagle, Gary B., Curtis, Jeffrey L., Adar, Sara D.
Publicado 2020

The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS

por Wells, J. Michael, Xing, Dongqi, Viera, Liliana, Burkes, Robert M., Wu, Yixin, Bhatt, Surya P., Dransfield, Mark T., Couper, David J., O’Neal, Wanda, Hoffman, Eric A., Gaggar, Amit, Barjaktarevic, Igor, Curtis, Jeffrey L., Labaki, Wassim W., Han, Mei Lan K., Freeman, Christine M., Putcha, Nirupama, Schlange, Thomas, Blalock, J. Edwin
Publicado 2019

Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Stu...

por Freeman, Christine M, Crudgington, Sean, Stolberg, Valerie R, Brown, Jeanette P, Sonstein, Joanne, Alexis, Neil E, Doerschuk, Claire M, Basta, Patricia V, Carretta, Elizabeth E, Couper, David J, Hastie, Annette T, Kaner, Robert J, O’Neal, Wanda K, Paine III, Robert, Rennard, Stephen I, Shimbo, Daichi, Woodruff, Prescott G, Zeidler, Michelle, Curtis, Jeffrey L
Publicado 2015

Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS

por Tejwani, Vickram, Woo, Han, Liu, Chen, Tillery, Anna K., Gassett, Amanda J., Kanner, Richard E., Hoffman, Eric A., Martinez, Fernando J., Woodruff, Prescott G., Barr, R. Graham, Fawzy, Ashraf, Koehler, Kirsten, Curtis, Jeffrey L., Freeman, Christine M., Cooper, Christopher B., Comellas, Alejandro P., Pirozzi, Cheryl, Paine, Robert, Tashkin, Donald, Krishnan, Jerry A., Sack, Coralynn, Putcha, Nirupama, Paulin, Laura M., Zusman, Marina, Kaufman, Joel D., Alexis, Neil E., Hansel, Nadia N.
Publicado 2022