Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy

por Watt, Andrew T., Swayze, Grant, Swayze, Eric E., Freier, Susan M.
Publicado 2020

Targeting of Repeated Sequences Unique to a Gene Results in Significant Increases in Antisense Oligonucleotide Potency

por Vickers, Timothy A., Freier, Susan M., Bui, Huynh-Hoa, Watt, Andrew, Crooke, Stanley T.
Publicado 2014

Regulation of the ESC transcriptome by nuclear long noncoding RNAs

por Bergmann, Jan H., Li, Jingjing, Eckersley-Maslin, Mélanie A., Rigo, Frank, Freier, Susan M., Spector, David L.
Publicado 2015

Natural antisense RNA promotes 3′ end processing and maturation of MALAT1 lncRNA

por Zong, Xinying, Nakagawa, Shinichi, Freier, Susan M., Fei, Jingyi, Ha, Taekjip, Prasanth, Supriya G., Prasanth, Kannanganattu V.
Publicado 2016

Using antisense technology to develop a novel therapy for α-1 antitrypsin deficient (AATD) liver disease and to model AATD lung disease

por Guo, Shuling, Booten, Sheri L, Watt, Andrew, Alvarado, Luis, Freier, Susan M, Teckman, Jeffery H, McCaleb, Michael L, Monia, Brett P
Publicado 2014

Potent inhibition of microRNA in vivo without degradation

por Davis, Scott, Propp, Stephanie, Freier, Susan M., Jones, Laura E., Serra, Martin J., Kinberger, Garth, Bhat, Balkrishen, Swayze, Eric E., Bennett, C. Frank, Esau, Christine
Publicado 2009

Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB

por Tripathi, Vidisha, Shen, Zhen, Chakraborty, Arindam, Giri, Sumanprava, Freier, Susan M., Wu, Xiaolin, Zhang, Yongqing, Gorospe, Myriam, Prasanth, Supriya G., Lal, Ashish, Prasanth, Kannanganattu V.
Publicado 2013

Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer

por Jadaliha, Mahdieh, Zong, Xinying, Malakar, Pushkar, Ray, Tania, Singh, Deepak K., Freier, Susan M., Jensen, Tor, Prasanth, Supriya G., Karni, Rotem, Ray, Partha S., Prasanth, Kannanganattu V.
Publicado 2016

Partial Hepatectomy Induced Long Noncoding RNA Inhibits Hepatocyte Proliferation during Liver Regeneration

por Huang, Lulu, Damle, Sagar S., Booten, Sheri, Singh, Priyam, Sabripour, Mahyar, Hsu, Jeff, Jo, Minji, Katz, Melanie, Watt, Andy, Hart, Christopher E., Freier, Susan M., Monia, Brett P., Guo, Shuling
Publicado 2015

Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients

por Skotte, Niels H., Southwell, Amber L., Østergaard, Michael E., Carroll, Jeffrey B., Warby, Simon C., Doty, Crystal N., Petoukhov, Eugenia, Vaid, Kuljeet, Kordasiewicz, Holly, Watt, Andrew T., Freier, Susan M., Hung, Gene, Seth, Punit P., Bennett, C. Frank, Swayze, Eric E., Hayden, Michael R.
Publicado 2014

Identification and Validation of PCAT14 as Prognostic Biomarker in Prostate Cancer()

por Shukla, Sudhanshu, Zhang, Xiang, Niknafs, Yashar S., Xiao, Lanbo, Mehra, Rohit, Cieślik, Marcin, Ross, Ashley, Schaeffer, Edward, Malik, Bhavna, Guo, Shuling, Freier, Susan M., Bui, Huynh-Hoa, Siddiqui, Javed, Jing, Xiaojun, Cao, Xuhong, Dhanasekaran, Saravana M., Feng, Felix Y., Chinnaiyan, Arul M., Malik, Rohit
Publicado 2016

A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability

por Jadaliha, Mahdieh, Gholamalamdari, Omid, Tang, Wei, Zhang, Yang, Petracovici, Ana, Hao, Qinyu, Tariq, Aamira, Kim, Tae Gyoon, Holton, Sarah E., Singh, Deepak K., Li, Xiao Ling, Freier, Susan M., Ambs, Stefan, Bhargava, Rohit, Lal, Ashish, Prasanth, Supriya G., Ma, Jian, Prasanth, Kannanganattu V.
Publicado 2018

Antagonism between splicing and microprocessor complex dictates the serum-induced processing of lnc-MIRHG for efficient cell cycle reentry

por Sun, Qinyu, Hao, Qinyu, Lin, Yo-Chuen, Song, You Jin, Bangru, Sushant, Arif, Waqar, Tripathi, Vidisha, Zhang, Yang, Cho, Jung-Hyun, Freier, Susan M., Jenkins, Lisa M., Ma, Jian, Yoon, Je-Hyun, Kalsotra, Auinash, Lal, Ashish, Prasanth, Supriya G., Prasanth, Kannanganattu V.
Publicado 2020

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

por Burel, Sebastien A., Hart, Christopher E., Cauntay, Patrick, Hsiao, Jill, Machemer, Todd, Katz, Melanie, Watt, Andy, Bui, Huynh-hoa, Younis, Husam, Sabripour, Mahyar, Freier, Susan M., Hung, Gene, Dan, Amy, Prakash, T.P., Seth, Punit P., Swayze, Eric E., Bennett, C. Frank, Crooke, Stanley T., Henry, Scott P.
Publicado 2016

2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 β-thalassemia patient cells restoring hemoglobin A production and chain rebalance

por Dong, Alisa, Ghiaccio, Valentina, Motta, Irene, Guo, Shuling, Peralta, Raechel, Freier, Susan M., Watt, Andy, Damle, Sagar, Ikawa, Yasuhiro, Jarocha, Danuta, Chappell, Maxwell, Stephanou, Coralea, Delbini, Paola, Chen, Connie, Christou, Soteroula, Kleanthous, Marina, Smith-Whitley, Kim, Manwani, Deepa, Casu, Carla, Abdulmalik, Osheiza, Cappellini, Maria Domenica, Rivella, Stefano, Breda, Laura
Publicado 2020

MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs

por Sun, Qinyu, Tripathi, Vidisha, Yoon, Je-Hyun, Singh, Deepak K, Hao, Qinyu, Min, Kyung-Won, Davila, Sylvia, Zealy, Richard W, Li, Xiao Ling, Polycarpou-Schwarz, Maria, Lehrmann, Elin, Zhang, Yongqing, Becker, Kevin G, Freier, Susan M, Zhu, Yuelin, Diederichs, Sven, Prasanth, Supriya G, Lal, Ashish, Gorospe, Myriam, Prasanth, Kannanganattu V
Publicado 2018

Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression

por Zhang, Yajia, Pitchiaya, Sethuramasundaram, Cieślik, Marcin, Niknafs, Yashar S., Tien, Jean C-Y., Hosono, Yasuyuki, Iyer, Matthew K., Yazdani, Sahr, Subramaniam, Shruthi, Shukla, Sudhanshu K., Jiang, Xia, Wang, Lisha, Liu, Tzu-Ying, Uhl, Michael, Gawronski, Alexander R., Qiao, Yuanyuan, Xiao, Lanbo, Dhanasekaran, Saravana M., Juckette, Kristin M., Kunju, Lakshmi P., Cao, Xuhong, Patel, Utsav, Batish, Mona, Shukla, Girish C., Paulsen, Michelle T., Ljungman, Mats, Jiang, Hui, Mehra, Rohit, Backofen, Rolf, Sahinalp, Cenk S., Freier, Susan M., Watt, Andrew T., Guo, Shuling, Wei, John T., Feng, Felix Y., Malik, Rohit, Chinnaiyan, Arul M.
Publicado 2018