Development of Broad‐Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CL(pro)

por Bacha, Usman, Barrila, Jennifer, Gabelli, Sandra B., Kiso, Yoshiaki, Mario Amzel, L., Freire, Ernesto
Publicado 2008

New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors

por Regnier, Thomas, Sarma, Diganta, Hidaka, Koushi, Bacha, Usman, Freire, Ernesto, Hayashi, Yoshio, Kiso, Yoshiaki
Publicado 2009

HIV-1 Vif N-terminal Motif is required for recruitment of Cul5 to Suppress APOBEC3

por Evans, Sean L, Schön, Arne, Gao, Qimeng, Han, Xue, Zhou, Xiaohong, Freire, Ernesto, Yu, Xiao-Fang
Publicado 2014

Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors

por Sydnes, Magne O., Hayashi, Yoshio, Sharma, Vinay K., Hamada, Takashi, Bacha, Usman, Barrila, Jennifer, Freire, Ernesto, Kiso, Yoshiaki
Publicado 2006

Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis

por Wang, Shusheng, Ketcham, Stephanie A., Schön, Arne, Goodman, Benjamin, Wang, Yueju, Yates, John, Freire, Ernesto, Schroer, Trina A., Zheng, Yixian
Publicado 2013

Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist

por Courter, Joel R., Madani, Navid, Sodroski, Joseph, Schön, Arne, Freire, Ernesto, Kwong, Peter D., Hendrickson, Wayne A., Chaiken, Irwin M., LaLonde, Judith M., Smith, Amos B.
Publicado 2014

Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies

por Thanigaimalai, Pillaiyar, Konno, Sho, Yamamoto, Takehito, Koiwai, Yuji, Taguchi, Akihiro, Takayama, Kentaro, Yakushiji, Fumika, Akaji, Kenichi, Chen, Shen-En, Naser-Tavakolian, Aurash, Schön, Arne, Freire, Ernesto, Hayashi, Yoshio
Publicado 2013

Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety

por Konno, Sho, Thanigaimalai, Pillaiyar, Yamamoto, Takehito, Nakada, Kiyohiko, Kakiuchi, Rie, Takayama, Kentaro, Yamazaki, Yuri, Yakushiji, Fumika, Akaji, Kenichi, Kiso, Yoshiaki, Kawasaki, Yuko, Chen, Shen-En, Freire, Ernesto, Hayashi, Yoshio
Publicado 2013

The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

por Herschhorn, Alon, Gu, Christopher, Moraca, Francesca, Ma, Xiaochu, Farrell, Mark, Smith, Amos B., Pancera, Marie, Kwong, Peter D., Schön, Arne, Freire, Ernesto, Abrams, Cameron, Blanchard, Scott C., Mothes, Walther, Sodroski, Joseph G.
Publicado 2017

Publisher Correction: The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

por Herschhorn, Alon, Gu, Christopher, Moraca, Francesca, Ma, Xiaochu, Farrell, Mark, Smith, Amos B., Pancera, Marie, Kwong, Peter D., Schön, Arne, Freire, Ernesto, Abrams, Cameron, Blanchard, Scott C., Mothes, Walther, Sodroski, Joseph G.
Publicado 2018

Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure–activity relationship study

por Thanigaimalai, Pillaiyar, Konno, Sho, Yamamoto, Takehito, Koiwai, Yuji, Taguchi, Akihiro, Takayama, Kentaro, Yakushiji, Fumika, Akaji, Kenichi, Kiso, Yoshiaki, Kawasaki, Yuko, Chen, Shen-En, Naser-Tavakolian, Aurash, Schön, Arne, Freire, Ernesto, Hayashi, Yoshio
Publicado 2013

Development of high-affinity nanobodies specific for Na(V)1.4 and Na(V)1.5 voltage-gated sodium channel isoforms

por Srinivasan, Lakshmi, Alzogaray, Vanina, Selvakumar, Dakshnamurthy, Nathan, Sara, Yoder, Jesse B., Wright, Katharine M., Klinke, Sebastián, Nwafor, Justin N., Labanda, María S., Goldbaum, Fernando A., Schön, Arne, Freire, Ernesto, Tomaselli, Gordon F., Amzel, L. Mario, Ben-Johny, Manu, Gabelli, Sandra B.
Publicado 2022

Crystal structures of trimeric HIV Env with entry inhibitors BMS-378806 and BMS-626529

por Pancera, Marie, Lai, Yen-Ting, Bylund, Tatsiana, Druz, Aliaksandr, Narpala, Sandeep, O’Dell, Sijy, Schön, Arne, Bailer, Robert T., Chuang, Gwo-Yu, Geng, Hui, Louder, Mark K., Rawi, Reda, Soumana, Djade I., Finzi, Andrés, Herschhorn, Alon, Madani, Navid, Sodroski, Joseph, Freire, Ernesto, Langley, David R., Mascola, John R., McDermott, Adrian B., Kwong, Peter D.
Publicado 2017

A human monoclonal antibody prevents malaria infection and defines a new site of vulnerability on Plasmodium falciparum circumsporozoite protein

por Kisalu, Neville K., Idris, Azza H., Weidle, Connor, Flores-Garcia, Yevel, Flynn, Barbara J., Sack, Brandon K., Murphy, Sean, Schön, Arne, Freire, Ernesto, Francica, Joseph R., Miller, Alex B., Gregory, Jason, March, Sandra, Liao, Hua-Xin, Haynes, Barton F., Wiehe, Kevin, Trama, Ashley M., Saunders, Kevin O., Gladden, Morgan A., Monroe, Anthony, Bonsignori, Mattia, Kanekiyo, Masaru, Wheatley, Adam K., McDermott, Adrian B., Farney, S. Katie, Chuang, Gwo-Yu, Zhang, Baoshan, Natasha, K C, Chakravarty, Sumana, Kwong, Peter D., Sinnis, Photini, Bhatia, Sangeeta N., Kappe, Stefan H. I., Sim, B. Kim Lee, Hoffman, Stephen L., Zavala, Fidel, Pancera, Marie, Seder, Robert A.
Publicado 2018

Crystal structure, conformational fixation, and entry-related interactions of mature ligand-free HIV-1 Env

por Kwon, Young Do, Pancera, Marie, Acharya, Priyamvada, Georgiev, Ivelin S., Crooks, Emma T., Gorman, Jason, Joyce, M. Gordon, Guttman, Miklos, Ma, Xiaochu, Narpala, Sandeep, Soto, Cinque, Terry, Daniel S., Yang, Yongping, Zhou, Tongqing, Ahlsen, Goran, Bailer, Robert T., Chambers, Michael, Chuang, Gwo-Yu, Doria-Rose, Nicole A., Druz, Aliaksandr, Hallen, Mark A., Harned, Adam, Kirys, Tatsiana, Louder, Mark K., O’Dell, Sijy, Ofek, Gilad, Osawa, Keiko, Prabhakaran, Madhu, Sastry, Mallika, Stewart-Jones, Guillaume B.E., Stuckey, Jonathan, Thomas, Paul V., Tittley, Tishina, Williams, Constance, Zhang, Baoshan, Zhao, Hong, Zhou, Zhou, Donald, Bruce R., Lee, Lawrence K., Zolla-Pazner, Susan, Baxa, Ulrich, Schön, Arne, Freire, Ernesto, Shapiro, Lawrence, Lee, Kelly K., Arthos, James, Munro, James B., Blanchard, Scott C., Mothes, Walther, Binley, James M., McDermott, Adrian B., Mascola, John R., Kwong, Peter D.
Publicado 2015