Human induced pluripotent stem cells as a tool for disease modeling and drug screening for COVID-19

por Nolasco, Patricia, Borsoi, Juliana, Moraes, Carolina Borsoi, Freitas-Junior, Lucio H., Pereira, Lygia Veiga
Publicado 2020

A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity

por Alcântara, Laura M., Ferreira, Thalita C. S., Fontana, Vanessa, Chatelain, Eric, Moraes, Carolina B., Freitas-Junior, Lucio H.
Publicado 2020

An Image Analysis Algorithm for Malaria Parasite Stage Classification and Viability Quantification

por Moon, Seunghyun, Lee, Sukjun, Kim, Heechang, Freitas-Junior, Lucio H., Kang, Myungjoo, Ayong, Lawrence, Hansen, Michael A. E.
Publicado 2013

Quantum dots: a new tool for anti-malarial drug assays

por Ku, Min-Je, Dossin, Fernando M, Choi, Youngseon, Moraes, Carolina B, Ryu, Jiyoung, Song, Rita, Freitas-Junior, Lucio H
Publicado 2011

An Image-Based Drug Susceptibility Assay Targeting the Placental Sequestration of Plasmodium falciparum-Infected Erythrocytes

por Ku, Min-Je, Dossin, Fernando de M., Hansen, Michael A. E., Genovesio, Auguste, Ayong, Lawrence, Freitas-Junior, Lucio H.
Publicado 2012

An Image-Based Algorithm for Precise and Accurate High Throughput Assessment of Drug Activity against the Human Parasite Trypanosoma cruzi

por Moon, Seunghyun, Siqueira-Neto, Jair L., Moraes, Carolina Borsoi, Yang, Gyongseon, Kang, Myungjoo, Freitas-Junior, Lucio H., Hansen, Michael A. E.
Publicado 2014

Transcription Sites Are Developmentally Regulated during the Asexual Cycle of Plasmodium falciparum

por Moraes, Carolina B., Dorval, Thierry, Contreras-Dominguez, Mónica, Dossin, Fernando de M., Hansen, Michael A. E., Genovesio, Auguste, Freitas-Junior, Lucio H.
Publicado 2013

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development

por Moraes, Carolina B., Giardini, Miriam A., Kim, Hwayoung, Franco, Caio H., Araujo-Junior, Adalberto M., Schenkman, Sergio, Chatelain, Eric, Freitas-Junior, Lucio H.
Publicado 2014

UV-C (254 nm) lethal doses for SARS-CoV-2

por Sabino, Caetano P., Sellera, Fábio P., Sales-Medina, Douglas F., Machado, Rafael Rahal Guaragna, Durigon, Edison Luiz, Freitas-Junior, Lucio H., Ribeiro, Martha S.
Publicado 2020

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

por Siqueira-Neto, Jair L., Moon, Seunghyun, Jang, Jiyeon, Yang, Gyongseon, Lee, Changbok, Moon, Hong Kee, Chatelain, Eric, Genovesio, Auguste, Cechetto, Jonathan, Freitas-Junior, Lucio H.
Publicado 2012

Automated Nuclear Analysis of Leishmania major Telomeric Clusters Reveals Changes in Their Organization during the Parasite's Life Cycle

por Dossin, Fernando de M., Dufour, Alexandre, Dusch, Elodie, Siqueira-Neto, Jair L., Moraes, Carolina B., Yang, Gyong Seon, Cano, Maria Isabel, Genovesio, Auguste, Freitas-Junior, Lucio H.
Publicado 2008

Identification of Novel Compounds Inhibiting Chikungunya Virus-Induced Cell Death by High Throughput Screening of a Kinase Inhibitor Library

por Cruz, Deu John M., Bonotto, Rafaela M., Gomes, Rafael G. B., da Silva, Camila T., Taniguchi, Juliana B., No, Joo Hwan, Lombardot, Benoit, Schwartz, Olivier, Hansen, Michael A. E., Freitas-Junior, Lucio H.
Publicado 2013

Antileishmanial High-Throughput Drug Screening Reveals Drug Candidates with New Scaffolds

por Siqueira-Neto, Jair L., Song, Ok-Ryul, Oh, Hyunrim, Sohn, Jeong-Hun, Yang, Gyongseon, Nam, Jiyoun, Jang, Jiyeon, Cechetto, Jonathan, Lee, Chang Bok, Moon, Seunghyun, Genovesio, Auguste, Chatelain, Eric, Christophe, Thierry, Freitas-Junior, Lucio H.
Publicado 2010

Visual Genome-Wide RNAi Screening to Identify Human Host Factors Required for Trypanosoma cruzi Infection

por Genovesio, Auguste, Giardini, Miriam A., Kwon, Yong-Jun, Dossin, Fernando de Macedo, Choi, Seo Yeon, Kim, Nam Youl, Kim, Hi Chul, Jung, Sung Yong, Schenkman, Sergio, Almeida, Igor C., Emans, Neil, Freitas-Junior, Lucio H.
Publicado 2011

From Live Cells to Caenorhabditis elegans: Selective Staining and Quantification of Lipid Structures Using a Fluorescent Hybrid Benzothiadiazole Derivative

por Mota, Alberto A. R., Correa, Jose R., de Andrade, Lorena P., Assumpção, José A. F., de Souza Cintra, Giovana A., Freitas-Junior, Lucio H., da Silva, Wender A., de Oliveira, Heibbe C. B., Neto, Brenno A. D.
Publicado 2018

Amazonian Plant Natural Products: Perspectives for Discovery of New Antimalarial Drug Leads

por Pohlit, Adrian Martin, Lima, Renata Braga Souza, Frausin, Gina, Silva, Luiz Francisco Rocha e, Lopes, Stefanie Costa Pinto, Moraes, Carolina Borsoi, Cravo, Pedro, Lacerda, Marcus Vinícius Guimarães, Siqueira, André Machado, Freitas-Junior, Lucio H., Costa, Fabio Trindade Maranhão
Publicado 2013

An Essential Nuclear Protein in Trypanosomes Is a Component of mRNA Transcription/Export Pathway

por Serpeloni, Mariana, Moraes, Carolina Borsoi, Muniz, João Renato Carvalho, Motta, Maria Cristina Machado, Ramos, Augusto Savio Peixoto, Kessler, Rafael Luis, Inoue, Alexandre Haruo, Duarte daRocha, Wanderson, Yamada-Ogatta, Sueli Fumie, Fragoso, Stenio Perdigão, Goldenberg, Samuel, Freitas-Junior, Lucio H., Ávila, Andréa Rodrigues
Publicado 2011

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity

por Franco, Caio H., Warhurst, David C., Bhattacharyya, Tapan, Au, Ho Y.A., Le, Hai, Giardini, Miriam A., Pascoalino, Bruno S., Torrecilhas, Ana Claudia, Romera, Lavinia M.D., Madeira, Rafael Pedro, Schenkman, Sergio, Freitas-Junior, Lucio H., Chatelain, Eric, Miles, Michael A., Moraes, Carolina B.
Publicado 2020

Nano-multilamellar lipid vesicles promote the induction of SARS-CoV-2 immune responses by a protein-based vaccine formulation

por Rodrigues-Jesus, Monica Josiane, Teixeira de Pinho Favaro, Marianna, Venceslau-Carvalho, Aléxia Adrianne, de Castro-Amarante, Maria Fernanda, da Silva Almeida, Bianca, de Oliveira Silva, Mariângela, Andreata-Santos, Robert, Gomes Barbosa, Cecilia, Brito, Samantha Carvalho Maia, Freitas-Junior, Lucio H., Boscardin, Silvia Beatriz, de Souza Ferreira, Luís Carlos
Publicado 2022

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity

por Di Pisa, Flavio, Landi, Giacomo, Dello Iacono, Lucia, Pozzi, Cecilia, Borsari, Chiara, Ferrari, Stefania, Santucci, Matteo, Santarem, Nuno, Cordeiro-da-Silva, Anabela, Moraes, Carolina B., Alcantara, Laura M., Fontana, Vanessa, Freitas-Junior, Lucio H., Gul, Sheraz, Kuzikov, Maria, Behrens, Birte, Pöhner, Ina, Wade, Rebecca C., Costi, Maria Paola, Mangani, Stefano
Publicado 2017