Affibody molecules as engineered protein drugs

por Frejd, Fredrik Y, Kim, Kyu-Tae
Publicado 2017

Targeting HER3 using mono- and bispecific antibodies or alternative scaffolds

por Malm, Magdalena, Frejd, Fredrik Y., Ståhl, Stefan, Löfblom, John
Publicado 2016

Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond

por Garousi, Javad, Orlova, Anna, Frejd, Fredrik Y., Tolmachev, Vladimir
Publicado 2020

In vivo depletion of serum IgG by an affibody molecule binding the neonatal Fc receptor

por Seijsing, Johan, Yu, Shengze, Frejd, Fredrik Y, Höiden-Guthenberg, Ingmarie, Gräslund, Torbjörn
Publicado 2018

An affibody-adalimumab hybrid blocks combined IL-6 and TNF-triggered serum amyloid A secretion in vivo

por Yu, Feifan, Gudmundsdotter, Lindvi, Akal, Anastassja, Gunneriusson, Elin, Frejd, Fredrik, Nygren, Per-Åke
Publicado 2014

Enhanced Therapeutic Effects of (177)Lu-DOTA-M5A in Combination with Heat Shock Protein 90 Inhibitor Onalespib in Colorectal Cancer Xenografts

por Mohajershojai, Tabassom, Spangler, Douglas, Chopra, Saloni, Frejd, Fredrik Y., Yazaki, Paul J., Nestor, Marika
Publicado 2023

In Vitro Characterization of (177)Lu-DOTA-M5A Anti-Carcinoembryonic Antigen Humanized Antibody and HSP90 Inhibition for Potentiated Radioimmunotherapy of Colorectal Cancer

por Mohajershojai, Tabassom, Jha, Preeti, Boström, Anna, Frejd, Fredrik Y., Yazaki, Paul J., Nestor, Marika
Publicado 2022

Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity

por Fleetwood, Filippa, Klint, Susanne, Hanze, Martin, Gunneriusson, Elin, Frejd, Fredrik Y., Ståhl, Stefan, Löfblom, John
Publicado 2014

Cellular Effects of HER3-Specific Affibody Molecules

por Göstring, Lovisa, Malm, Magdalena, Höidén-Guthenberg, Ingmarie, Frejd, Fredrik Y., Ståhl, Stefan, Löfblom, John, Gedda, Lars
Publicado 2012

Radionuclide Therapy of HER2-Expressing Xenografts Using [(177)Lu]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab

por Liu, Yongsheng, Xu, Tianqi, Vorobyeva, Anzhelika, Loftenius, Annika, Bodenko, Vitalina, Orlova, Anna, Frejd, Fredrik Y., Tolmachev, Vladimir
Publicado 2023

Current status of contemporary diagnostic radiotracers in the management of breast cancer: first steps toward theranostic applications

por Altena, Renske, Tzortzakakis, Antonios, Af Burén, Siri, Tran, Thuy A., Frejd, Fredrik Y., Bergh, Jonas, Axelsson, Rimma
Publicado 2023

Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer

por Alhuseinalkhudhur, Ali, Lubberink, Mark, Lindman, Henrik, Tolmachev, Vladimir, Frejd, Fredrik Y., Feldwisch, Joachim, Velikyan, Irina, Sörensen, Jens
Publicado 2020

Imaging of CAIX-expressing xenografts in vivo using (99m)Tc-HEHEHE-ZCAIX:1 Affibody molecule

por HONARVAR, HADIS, GAROUSI, JAVAD, GUNNERIUSSON, ELIN, HÖIDÉN-GUTHENBERG, INGMARIE, ALTAI, MOHAMED, WIDSTRÖM, CHARLES, TOLMACHEV, VLADIMIR, FREJD, FREDRIK Y.
Publicado 2014

In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin-binding therapeutic affibody construct

por Bass, Tarek Z., Rosestedt, Maria, Mitran, Bogdan, Frejd, Fredrik Y., Löfblom, John, Tolmachev, Vladimir, Ståhl, Stefan, Orlova, Anna
Publicado 2017

Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody(®) Molecules (177)Lu-ABY-271 and (177)Lu-ABY-027: Impact of DOTA Position on ABD Domain

por Liu, Yongsheng, Vorobyeva, Anzhelika, Xu, Tianqi, Orlova, Anna, Loftenius, Annika, Bengtsson, Theresa, Jonasson, Per, Tolmachev, Vladimir, Frejd, Fredrik Y.
Publicado 2021

Preclinical Evaluation of (99m)Tc-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

por Oroujeni, Maryam, Rinne, Sara S., Vorobyeva, Anzhelika, Loftenius, Annika, Feldwisch, Joachim, Jonasson, Per, Chernov, Vladimir, Orlova, Anna, Frejd, Fredrik Y., Tolmachev, Vladimir
Publicado 2021

A PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation

por Mega, Alessandro, Mebrahtu, Aman, Aniander, Gustav, Ryer, Eva, Sköld, Annette, Sandegren, Anna, Backström Rydin, Eva, Rockberg, Johan, Östman, Arne, Frejd, Fredrik Y.
Publicado 2023

Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule (188)Re-ZHER2:41071

por Liu, Yongsheng, Vorobyeva, Anzhelika, Orlova, Anna, Konijnenberg, Mark W., Xu, Tianqi, Bragina, Olga, Loftenius, Annika, Rosander, Erica, Frejd, Fredrik Y., Tolmachev, Vladimir
Publicado 2022

Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3

por Oroujeni, Maryam, Bezverkhniaia, Ekaterina A., Xu, Tianqi, Liu, Yongsheng, Plotnikov, Evgenii V., Karlberg, Ida, Ryer, Eva, Orlova, Anna, Tolmachev, Vladimir, Frejd, Fredrik Y.
Publicado 2022

Phase I clinical evaluation of (99m)Tc-labeled Affibody molecule for imaging HER2 expression in breast cancer

por Bragina, Olga, Chernov, Vladimir, Larkina, Mariia, Rybina, Anstasiya, Zelchan, Roman, Garbukov, Eugeniy, Oroujeni, Maryam, Loftenius, Annika, Orlova, Anna, Sörensen, Jens, Frejd, Fredrik Y., Tolmachev, Vladimir
Publicado 2023