Function-first antibody discovery: Embracing the unpredictable biology of antibodies

por Frendéus, Björn
Publicado 2013

Targeting the Antibody Checkpoints to Enhance Cancer Immunotherapy–Focus on FcγRIIB

por Teige, Ingrid, Mårtensson, Linda, Frendéus, Björn L.
Publicado 2019

Interleukin 8 Receptor Deficiency Confers Susceptibility to Acute Experimental Pyelonephritis and May Have a Human Counterpart

por Frendéus, Björn, Godaly, Gabriela, Hang, Long, Karpman, Diana, Lundstedt, Ann-Charlotte, Svanborg, Catharina
Publicado 2000

Sequence enrichment profiles enable target-agnostic antibody generation for a broad range of antigens

por Mattsson, Jenny, Ljungars, Anne, Carlsson, Anders, Svensson, Carolin, Nilsson, Björn, Ohlin, Mats, Frendéus, Björn
Publicado 2023

Human leukocyte immunoglobulin-like receptors in health and disease

por Redondo-García, Silvia, Barritt, Christopher, Papagregoriou, Charys, Yeboah, Muchaala, Frendeus, Björn, Cragg, Mark S., Roghanian, Ali
Publicado 2023

Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes

por Ljungars, Anne, Svensson, Carolin, Carlsson, Anders, Birgersson, Elin, Tornberg, Ulla-Carin, Frendéus, Björn, Ohlin, Mats, Mattsson, Mikael
Publicado 2019

FcγRIIb Expression Is Decreased on Naive and Marginal Zone-Like B Cells From Females With Multiple Sclerosis

por Trend, Stephanie, Leffler, Jonatan, Teige, Ingrid, Frendéus, Björn, Kermode, Allan G., French, Martyn A., Hart, Prue H.
Publicado 2021

A single-arm, open-label, phase 2 clinical trial evaluating disease response following treatment with BI-505, a human anti-intercellular adhesion molecule-1 monoclonal antibody, in...

por Wichert, Stina, Juliusson, Gunnar, Johansson, Åsa, Sonesson, Elisabeth, Teige, Ingrid, Wickenberg, Anna Teige, Frendeus, Björn, Korsgren, Magnus, Hansson, Markus
Publicado 2017

Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing

por Mattsson, Jenny, Ekdahl, Ludvig, Junghus, Fredrik, Ajore, Ram, Erlandsson, Eva, Niroula, Abhishek, Pertesi, Maroulio, Frendéus, Björn, Teige, Ingrid, Nilsson, Björn
Publicado 2021

Evaluating Anti-CD32b F(ab) Conformation Using Molecular Dynamics and Small-Angle X-Ray Scattering

por Sutton, Emma J., Bradshaw, Richard T., Orr, Christian M., Frendéus, Bjorn, Larsson, Gunilla, Teige, Ingrid, Cragg, Mark S., Tews, Ivo, Essex, Jonathan W.
Publicado 2018

Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8(+) T cell immunity to reject ‘cold’ tumors

por Semmrich, Monika, Marchand, Jean-Baptiste, Fend, Laetitia, Rehn, Matilda, Remy, Christelle, Holmkvist, Petra, Silvestre, Nathalie, Svensson, Carolin, Kleinpeter, Patricia, Deforges, Jules, Junghus, Fred, Cleary, Kirstie L, Bodén, Mimoza, Mårtensson, Linda, Foloppe, Johann, Teige, Ingrid, Quéméneur, Eric, Frendéus, Björn
Publicado 2022

Targeting FcγRIIB by antagonistic antibody BI-1206 improves the efficacy of rituximab-based therapies in aggressive mantle cell lymphoma

por Jiang, Vivian Changying, Liu, Yang, Jordan, Alexa, Leeming, Angela, McIntosh, Joseph, Huang, Shengjian, Zhang, Rongjia, Cai, Qingsong, Chen, Zhihong, Li, Yijing, Che, Yuxuan, Nie, Lei, Karlsson, Ingrid, Mårtensson, Linda, Kovacek, Mathilda, Teige, Ingrid, Frendéus, Björn, Wang, Michael
Publicado 2022

Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs

por Al-Mashhadi, Ahmed Ludvigsen, Poulsen, Christian Bo, von Wachenfeldt, Karin, Robertson, Anna-Karin, Bentzon, Jacob Fog, Nielsen, Lars Bo, Thygesen, Jesper, Tolbod, Lars Poulsen, Larsen, Jens Rolighed, Moestrup, Søren Kragh, Frendéus, Björn, Mortensen, Brynjulf, Drouet, Ludovic, Al-Mashhadi, Rozh H., Falk, Erling
Publicado 2018

LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation

por Yeboah, Muchaala, Papagregoriou, Charys, Jones, Des C., Chan, H.T. Claude, Hu, Guangan, McPartlan, Justine S., Schiött, Torbjörn, Mattson, Ulrika, Mockridge, C. Ian, Tornberg, Ulla-Carin, Hambe, Björn, Ljungars, Anne, Mattsson, Mikael, Tews, Ivo, Glennie, Martin J., Thirdborough, Stephen M., Trowsdale, John, Frendeus, Björn, Chen, Jianzhu, Cragg, Mark S., Roghanian, Ali
Publicado 2020

FcγRIIB controls antibody-mediated target cell depletion by ITIM-independent mechanisms

por Simpson, Alexander P., Roghanian, Ali, Oldham, Robert J., Chan, H.T. Claude, Penfold, Christine A., Kim, Hyung J., Inzhelevskaya, Tatyana, Mockridge, C. Ian, Cox, Kerry L., Bogdanov, Yury D., James, Sonya, Tutt, Alison L., Rycroft, Daniel, Morley, Peter, Dahal, Lekh N., Teige, Ingrid, Frendeus, Björn, Beers, Stephen A., Cragg, Mark S.
Publicado 2022

Domain binding and isotype dictate the activity of anti-human OX40 antibodies

por Griffiths, Jordana, Hussain, Khiyam, Smith, Hannah L, Sanders, Theodore, Cox, Kerry L, Semmrich, Monika, Mårtensson, Linda, Kim, Jinny, Inzhelevskaya, Tatyana, Penfold, Chris A, Tutt, Alison L, Mockridge, C Ian, Chan, HT Claude, English, Vikki, French, Ruth F, Teige, Ingrid, Al-Shamkhani, Aymen, Glennie, Martin J, Frendeus, Bjorn L, Willoughby, Jane E, Cragg, Mark S
Publicado 2020

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

por Arce Vargas, Frederick, Furness, Andrew J.S., Litchfield, Kevin, Joshi, Kroopa, Rosenthal, Rachel, Ghorani, Ehsan, Solomon, Isabelle, Lesko, Marta H., Ruef, Nora, Roddie, Claire, Henry, Jake Y., Spain, Lavinia, Ben Aissa, Assma, Georgiou, Andrew, Wong, Yien Ning Sophia, Smith, Myles, Strauss, Dirk, Hayes, Andrew, Nicol, David, O'Brien, Tim, Mårtensson, Linda, Ljungars, Anne, Teige, Ingrid, Frendéus, Björn, Pule, Martin, Marafioti, Teresa, Gore, Martin, Larkin, James, Turajlic, Samra, Swanton, Charles, Peggs, Karl S., Quezada, Sergio A.
Publicado 2018

HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy

por Hussain, Khiyam, Liu, Rena, Smith, Rosanna C. G., Müller, Kri T. J., Ghorbani, Mohammadmersad, Macari, Sofia, Cleary, Kirstie L. S., Oldham, Robert J., Foxall, Russell B., James, Sonya, Booth, Steven G., Murray, Tom, Dahal, Lekh N., Hargreaves, Chantal E., Kemp, Robert S., Longley, Jemma, Douglas, James, Markham, Hannah, Chee, Serena J., Stopforth, Richard J., Roghanian, Ali, Carter, Matthew J., Ottensmeier, Christian H., Frendéus, Bjorn, Cutress, Ramsey I., French, Ruth R., Glennie, Martin J., Strefford, Jonathan C., Thirdborough, Stephen M., Beers, Stephen A., Cragg, Mark S.
Publicado 2022