The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing

por Begolo, Daniela, Vincent, Isabel M., Giordani, Federica, Pöhner, Ina, Witty, Michael J., Rowan, Timothy G., Bengaly, Zakaria, Gillingwater, Kirsten, Freund, Yvonne, Wade, Rebecca C., Barrett, Michael P., Clayton, Christine
Publicado 2018

Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation

por Sindhe, Kirthana M. V., Wu, Wesley, Legac, Jenny, Zhang, Yong-Kang, Easom, Eric E., Cooper, Roland A., Plattner, Jacob J., Freund, Yvonne R., DeRisi, Joseph L., Rosenthal, Philip J.
Publicado 2020

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase

por Palencia, Andrés, Liu, Ru-Juan, Lukarska, Maria, Gut, Jiri, Bougdour, Alexandre, Touquet, Bastien, Wang, En-Duo, Li, Xianfeng, Alley, M. R. K., Freund, Yvonne R., Rosenthal, Philip J., Hakimi, Mohamed-Ali, Cusack, Stephen
Publicado 2016

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei

por Steketee, Pieter C., Vincent, Isabel M., Achcar, Fiona, Giordani, Federica, Kim, Dong-Hyun, Creek, Darren J., Freund, Yvonne, Jacobs, Robert, Rattigan, Kevin, Horn, David, Field, Mark C., MacLeod, Annette, Barrett, Michael P.
Publicado 2018

Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis

por Palencia, Andrés, Bougdour, Alexandre, Brenier‐Pinchart, Marie‐Pierre, Touquet, Bastien, Bertini, Rose‐Laurence, Sensi, Cristina, Gay, Gabrielle, Vollaire, Julien, Josserand, Véronique, Easom, Eric, Freund, Yvonne R, Pelloux, Hervé, Rosenthal, Philip J, Cusack, Stephen, Hakimi, Mohamed‐Ali
Publicado 2017

Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

por Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Jacobs, Robert T., Guo, Denghui, Sanders, Virginia, Freund, Yvonne R., Campo, Brice, Rosenthal, Philip J., Bu, Wei, Gamo, Francisco-Javier, Sanz, Laura M., Ge, Min, Li, Liang, Ding, Jie, Yang, Yin
Publicado 2015

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles

por Zhang, Ning, Zoltner, Martin, Leung, Ka-Fai, Scullion, Paul, Hutchinson, Sebastian, del Pino, Ricardo C., Vincent, Isabel M., Zhang, Yong-Kang, Freund, Yvonne R., Alley, Michael R. K., Jacobs, Robert T., Read, Kevin D., Barrett, Michael P., Horn, David, Field, Mark C.
Publicado 2018

Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

por Akama, Tsutomu, Zhang, Yong-Kang, Freund, Yvonne R., Berry, Pamela, Lee, Joanne, Easom, Eric E., Jacobs, Robert T., Plattner, Jacob J., Witty, Michael J., Peter, Rosemary, Rowan, Tim G., Gillingwater, Kirsten, Brun, Reto, Nare, Bakela, Mercer, Luke, Xu, Musheng, Wang, Jiangong, Liang, Hao
Publicado 2018

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

por Lunde, Christopher S., Stebbins, Erin E., Jumani, Rajiv S., Hasan, Md Mahmudul, Miller, Peter, Barlow, John, Freund, Yvonne R., Berry, Pamela, Stefanakis, Rianna, Gut, Jiri, Rosenthal, Philip J., Love, Melissa S., McNamara, Case W., Easom, Eric, Plattner, Jacob J., Jacobs, Robert T., Huston, Christopher D.
Publicado 2019

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis

por Ehrens, Alexandra, Lunde, Christopher S., Jacobs, Robert T., Struever, Dominique, Koschel, Marianne, Frohberger, Stefan J., Lenz, Franziska, Fendler, Martina, Turner, Joseph D., Ward, Stephen A., Taylor, Mark J., Freund, Yvonne R., Stefanakis, Rianna, Easom, Eric, Li, Xianfeng, Plattner, Jacob J., Hoerauf, Achim, Hübner, Marc P.
Publicado 2020

Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs

por Carter, David S., Jacobs, Robert T., Freund, Yvonne R., Berry, Pamela W., Akama, Tsutomu, Easom, Eric E., Lunde, Christopher S., Rock, Fernando, Stefanakis, Rianna, McKerrow, James, Fischer, Chelsea, Bulman, Christina A., Lim, Kee Chong, Suzuki, Brian M., Tricoche, Nancy, Sakanari, Judy A., Lustigman, Sara, Plattner, Jacob J.
Publicado 2019

Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates

por Padilla, Angel M., Wang, Wei, Akama, Tsutomu, Carter, David S., Easom, Eric, Freund, Yvonne, Halladay, Jason S., Liu, Yang, Hamer, Sarah A., Hodo, Carolyn L., Wilkerson, Gregory K., Orr, Dylan, White, Brooke, George, Arlene, Shen, Huifeng, Jin, Yiru, Wang, Michael Zhuo, Tse, Susanna, Jacobs, Robert T., Tarleton, Rick L.
Publicado 2022

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs

por Giordani, Federica, Paape, Daniel, Vincent, Isabel M., Pountain, Andrew W., Fernández-Cortés, Fernando, Rico, Eva, Zhang, Ning, Morrison, Liam J., Freund, Yvonne, Witty, Michael J., Peter, Rosemary, Edwards, Darren Y., Wilkes, Jonathan M., van der Hooft, Justin J. J., Regnault, Clément, Read, Kevin D., Horn, David, Field, Mark C., Barrett, Michael P.
Publicado 2020

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

por Mowbray, Charles E., Braillard, Stéphanie, Glossop, Paul A., Whitlock, Gavin A., Jacobs, Robert T., Speake, Jason, Pandi, Bharathi, Nare, Bakela, Maes, Louis, Yardley, Vanessa, Freund, Yvonne, Wall, Richard J., Carvalho, Sandra, Bello, Davide, Van den Kerkhof, Magali, Caljon, Guy, Gilbert, Ian H., Corpas-Lopez, Victoriano, Lukac, Iva, Patterson, Stephen, Zuccotto, Fabio, Wyllie, Susan
Publicado 2021

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

por Sonoiki, Ebere, Ng, Caroline L., Lee, Marcus C. S., Guo, Denghui, Zhang, Yong-Kang, Zhou, Yasheen, Alley, M. R. K., Ahyong, Vida, Sanz, Laura M., Lafuente-Monasterio, Maria Jose, Dong, Chen, Schupp, Patrick G., Gut, Jiri, Legac, Jenny, Cooper, Roland A., Gamo, Francisco-Javier, DeRisi, Joseph, Freund, Yvonne R., Fidock, David A., Rosenthal, Philip J.
Publicado 2017

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

por Jacobs, Robert T., Nare, Bakela, Wring, Stephen A., Orr, Matthew D., Chen, Daitao, Sligar, Jessica M., Jenks, Matthew X., Noe, Robert A., Bowling, Tana S., Mercer, Luke T., Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J., Yarlett, Nigel, Plattner, Jacob J., Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y.-K., Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert
Publicado 2011

Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs

por Akama, Tsutomu, Freund, Yvonne R., Berry, Pamela W., Carter, David S., Easom, Eric E., Jarnagin, Kurt, Lunde, Christopher S., Plattner, Jacob J., Rock, Fernando, Stefanakis, Rianna, Fischer, Chelsea, Bulman, Christina A., Lim, Kee Chong, Suzuki, Brian M., Tricoche, Nancy, Mansour, Abdelmoneim, DiCosty, Utami, McCall, Scott, Carson, Ben, McCall, John W., McKerrow, James, Hübner, Marc P., Specht, Sabine, Hoerauf, Achim, Lustigman, Sara, Sakanari, Judy A., Jacobs, Robert T.
Publicado 2019

Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

por Jacobs, Robert T., Lunde, Christopher S., Freund, Yvonne R., Hernandez, Vincent, Li, Xianfeng, Xia, Yi, Carter, David S., Berry, Pamela W., Halladay, Jason, Rock, Fernando, Stefanakis, Rianna, Easom, Eric, Plattner, Jacob J., Ford, Louise, Johnston, Kelly L., Cook, Darren A. N., Clare, Rachel, Cassidy, Andrew, Myhill, Laura, Tyrer, Hayley, Gamble, Joanne, Guimaraes, Ana F., Steven, Andrew, Lenz, Franziska, Ehrens, Alexandra, Frohberger, Stefan J., Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P., McNamara, Case W., Bakowski, Malina A., Turner, Joseph D., Taylor, Mark J., Ward, Stephen A.
Publicado 2019