A common feature pharmacophore for FDA-approved drugs inhibiting the Ebola virus

por Ekins, Sean, Freundlich, Joel S., Coffee, Megan
Publicado 2014

Liquid chromatography-mass spectrometry-based protocol to measure drug accumulation in Mycobacterium tuberculosis and its host cell

por Ahn, Yong-Mo, Lavin, Richard C., Tan, Shumin, Freundlich, Joel S.
Publicado 2023

Pruned Machine Learning Models to Predict Aqueous Solubility

por Perryman, Alexander L., Inoyama, Daigo, Patel, Jimmy S., Ekins, Sean, Freundlich, Joel S.
Publicado 2020

Essential Metabolites of Mycobacterium tuberculosis and Their Mimics

por Lamichhane, Gyanu, Freundlich, Joel S., Ekins, Sean, Wickramaratne, Niluka, Nolan, Scott T., Bishai, William R.
Publicado 2011

Machine Learning Model Analysis and Data Visualization with Small Molecules Tested in a Mouse Model of Mycobacterium tuberculosis Infection (2014–2015)

por Ekins, Sean, Perryman, Alexander L., Clark, Alex M., Reynolds, Robert C., Freundlich, Joel S.
Publicado 2016

Machine learning models identify molecules active against the Ebola virus in vitro

por Ekins, Sean, Freundlich, Joel S., Clark, Alex M., Anantpadma, Manu, Davey, Robert A., Madrid, Peter
Publicado 2017

Mycobacterium tuberculosis KasA as a drug target: Structure-based inhibitor design

por Rudraraju, Reshma S., Daher, Samer S., Gallardo-Macias, Ricardo, Wang, Xin, Neiditch, Matthew B., Freundlich, Joel S.
Publicado 2022

Enhancing Hit Identification in Mycobacterium tuberculosis Drug Discovery Using Validated Dual-Event Bayesian Models

por Ekins, Sean, Reynolds, Robert C., Franzblau, Scott G., Wan, Baojie, Freundlich, Joel S., Bunin, Barry A.
Publicado 2013

Looking Back to the Future: Predicting in Vivo Efficacy of Small Molecules versus Mycobacterium tuberculosis

por Ekins, Sean, Pottorf, Richard, Reynolds, Robert C., Williams, Antony J., Clark, Alex M., Freundlich, Joel S.
Publicado 2014

Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets

por Clark, Alex M., Dole, Krishna, Coulon-Spektor, Anna, McNutt, Andrew, Grass, George, Freundlich, Joel S., Reynolds, Robert C., Ekins, Sean
Publicado 2015

Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection

por Lane, Thomas R., Massey, Christopher, Comer, Jason E., Anantpadma, Manu, Freundlich, Joel S., Davey, Robert A., Madrid, Peter B., Ekins, Sean
Publicado 2019

Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

por Palaninathan, Satheesh K., Mohamedmohaideen, Nilofar N., Orlandini, Elisabetta, Ortore, Gabriella, Nencetti, Susanna, Lapucci, Annalina, Rossello, Armando, Freundlich, Joel S., Sacchettini, James C.
Publicado 2009

A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis

por Forbes, Lauren, Ebsworth-Mojica, Katherine, DiDone, Louis, Li, Shao-Gang, Freundlich, Joel S., Connell, Nancy, Dunman, Paul M., Krysan, Damian J.
Publicado 2015

Assessment of carbapenems in a mouse model of Mycobacterium tuberculosis infection

por Jadhav, Ravindra, Gallardo-Macias, Ricardo, Kumar, Gaurav, Daher, Samer S., Kaushik, Amit, Bigelow, Kristina M., Nuermberger, Eric L., Lamichhane, Gyanu, Freundlich, Joel S.
Publicado 2021

Structural basis of DSF recognition by its receptor RpfR and its regulatory interaction with the DSF synthase RpfF

por Waldron, Evan J., Snyder, Daniel, Fernandez, Nicolas L., Sileo, Emily, Inoyama, Daigo, Freundlich, Joel S., Waters, Christopher M., Cooper, Vaughn S., Neiditch, Matthew B.
Publicado 2019

Computational Approaches to Identify Molecules Binding to Mycobacterium tuberculosis KasA

por Puhl, Ana C., Lane, Thomas R., Vignaux, Patricia A., Zorn, Kimberley M., Capodagli, Glenn C., Neiditch, Matthew B., Freundlich, Joel S., Ekins, Sean
Publicado 2020

Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads

por Anantpadma, Manu, Lane, Thomas, Zorn, Kimberley M., Lingerfelt, Mary A., Clark, Alex M., Freundlich, Joel S., Davey, Robert A., Madrid, Peter B., Ekins, Sean
Publicado 2019

Open drug discovery for the Zika virus

por Ekins, Sean, Mietchen, Daniel, Coffee, Megan, Stratton, Thomas P, Freundlich, Joel S, Freitas-Junior, Lucio, Muratov, Eugene, Siqueira-Neto, Jair, Williams, Antony J, Andrade, Carolina
Publicado 2016

1954. Dynamic PET facilitated Modeling and Novel Antibiotic Regimens for Tuberculous Meningitis due to Multidrug-Resistant Strains

por Chen, Xueyi, Nino-Meza, Oscar J, Sarhan, Mona O, Arun, Bhavatharini, Jeon, Byeonghoon, Ordonez, Alvaro A, Carroll, Laurence S, Peloquin, Charles A, Freundlich, Joel, Ivaturi, Vijay, Jain, Sanjay K
Publicado 2023

Redesign of Rifamycin Antibiotics to Overcome ADP‐Ribosylation‐Mediated Resistance

por Lan, Tian, Ganapathy, Uday S., Sharma, Sachin, Ahn, Yong‐Mo, Zimmerman, Matthew, Molodtsov, Vadim, Hegde, Pooja, Gengenbacher, Martin, Ebright, Richard H., Dartois, Véronique, Freundlich, Joel S., Dick, Thomas, Aldrich, Courtney C.
Publicado 2022