Emergence of biopharmaceutical innovators in China, India, Brazil, and South Africa as global competitors and collaborators

por Rezaie, Rahim, McGahan, Anita M, Frew, Sarah E, Daar, Abdallah S, Singer, Peter A
Publicado 2012

Chinese health biotech and the billion-patient market

por Frew, Sarah E, Sammut, Stephen M, Shore, Alysha F, Ramjist, Joshua K, Al-Bader, Sara, Rezaie, Rahim, Daar, Abdallah S, Singer, Peter A
Publicado 2008

Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity

por Atkinson, Benjamin N., Willis, Nicky J., Zhao, Yuguang, Patel, Chandni, Frew, Sarah, Costelloe, Kathryn, Magno, Lorenza, Svensson, Fredrik, Jones, E. Yvonne, Fish, Paul V.
Publicado 2023

Structural Insights into Notum Covalent Inhibition

por Zhao, Yuguang, Svensson, Fredrik, Steadman, David, Frew, Sarah, Monaghan, Amy, Bictash, Magda, Moreira, Tiago, Chalk, Rod, Lu, Weixian, Fish, Paul V., Jones, E. Yvonne
Publicado 2021

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

por Atkinson, Benjamin N., Steadman, David, Zhao, Yuguang, Sipthorp, James, Vecchia, Luca, Ruza, Reinis R., Jeganathan, Fiona, Lines, Georgie, Frew, Sarah, Monaghan, Amy, Kjær, Svend, Bictash, Magda, Jones, E. Yvonne, Fish, Paul V.
Publicado 2019

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors

por Atkinson, Benjamin N., Steadman, David, Mahy, William, Zhao, Yuguang, Sipthorp, James, Bayle, Elliott D., Svensson, Fredrik, Papageorgiou, George, Jeganathan, Fiona, Frew, Sarah, Monaghan, Amy, Bictash, Magda, Jones, E. Yvonne, Fish, Paul V.
Publicado 2020

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit

por Willis, Nicky J., Mahy, William, Sipthorp, James, Zhao, Yuguang, Woodward, Hannah L., Atkinson, Benjamin N., Bayle, Elliott D., Svensson, Fredrik, Frew, Sarah, Jeganathan, Fiona, Monaghan, Amy, Benvegnù, Stefano, Jolly, Sarah, Vecchia, Luca, Ruza, Reinis R., Kjær, Svend, Howell, Steven, Snijders, Ambrosius P., Bictash, Magda, Salinas, Patricia C., Vincent, Jean-Paul, Jones, E. Yvonne, Whiting, Paul, Fish, Paul V.
Publicado 2022