Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter

por Liebchen, Uwe, Briegel, Josef, Brinkmann, Alexander, Frey, Otto, Wicha, Sebastian G.
Publicado 2023

Validation and Application of an HPLC-UV Method for Routine Therapeutic Drug Monitoring of Cefiderocol

por Zimmer, Julia, Röhr, Anka C., Kluge, Stefan, Faller, Jonas, Frey, Otto R., Wichmann, Dominic, König, Christina
Publicado 2021

Cefiderocol in Critically Ill Patients with Multi-Drug Resistant Pathogens: Real-Life Data on Pharmacokinetics and Microbiological Surveillance

por König, Christina, Both, Anna, Rohde, Holger, Kluge, Stefan, Frey, Otto R., Röhr, Anka C., Wichmann, Dominic
Publicado 2021

Correction: König et al. Cefiderocol in Critically Ill Patients with Multi-Drug Resistant Pathogens: Real-Life Data on Pharmacokinetics and Microbiological Surveillance. Antibiotic...

por König, Christina, Both, Anna, Rohde, Holger, Kluge, Stefan, Frey, Otto R., Röhr, Anka C., Wichmann, Dominic
Publicado 2021

Excessive unbound cefazolin concentrations in critically ill patients receiving veno-arterial extracorporeal membrane oxygenation (vaECMO): an observational study

por Booke, Hendrik, Frey, Otto R., Röhr, Anka C., Chiriac, Ute, Zacharowski, Kai, Holubec, Tomas, Adam, Elisabeth H.
Publicado 2021

Validation and Application of an HPLC-UV Method for Routine Therapeutic Drug Monitoring of Dalbavancin

por Chiriac, Ute, Rau, Heike, Frey, Otto R., Röhr, Anka C., Klein, Sabrina, Meyer, Anna L., Morath, Benedict
Publicado 2022

Ciprofloxacin in Patients Undergoing Extracorporeal Membrane Oxygenation (ECMO): A Population Pharmacokinetic Study

por Alihodzic, Dzenefa, Wicha, Sebastian G., Frey, Otto R., König, Christina, Baehr, Michael, Jarczak, Dominik, Kluge, Stefan, Langebrake, Claudia
Publicado 2022

Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study

por Blassmann, Ute, Roehr, Anka C., Frey, Otto R., Vetter-Kerkhoff, Cornelia, Thon, Niklas, Hope, William, Briegel, Josef, Huge, Volker
Publicado 2016

Pharmacokinetics of tigecycline in critically ill patients with liver failure defined by maximal liver function capacity test (LiMAx)

por Alraish, Rawan, Wicha, Sebastian G., Frey, Otto R., Roehr, Anka C., Pratschke, Johann, Stockmann, Martin, Wuensch, Tilo, Kaffarnik, Magnus
Publicado 2020

Personalized ß-lactam dosing in patients with coronavirus disease 2019 (COVID-19) and pneumonia: A retrospective analysis on pharmacokinetics and pharmacokinetic target attainment

por Chiriac, Ute, Frey, Otto R., Roehr, Anka C., Koeberer, Andreas, Gronau, Patrick, Fuchs, Thomas, Roberts, Jason A., Brinkmann, Alexander
Publicado 2021

Systematic Evaluation of Pharmacokinetic Models for Model-Informed Precision Dosing of Meropenem in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy

por Schatz, Lea Marie, Brinkmann, Alexander, Röhr, Anka, Frey, Otto, Greppmair, Sebastian, Weinelt, Ferdinand, Zoller, Michael, Scharf, Christina, Hempel, Georg, Liebchen, Uwe
Publicado 2023

Software- and TDM-Guided Dosing of Meropenem Promises High Rates of Target Attainment in Critically Ill Patients

por Chiriac, Ute, Richter, Daniel, Frey, Otto R., Röhr, Anka C., Helbig, Sophia, Hagel, Stefan, Liebchen, Uwe, Weigand, Markus A., Brinkmann, Alexander
Publicado 2023

Daptomycin Pharmacokinetics in Blood and Wound Fluid in Critical Ill Patients with Left Ventricle Assist Devices

por Calov, Stefanie, Munzel, Frederik, Roehr, Anka C., Frey, Otto, Higuita, Lina Maria Serna, Wied, Petra, Rosenberger, Peter, Haeberle, Helene A., Ngamsri, Kristian-Christos
Publicado 2023

Therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam to improve outcome in patients with sepsis (TARGET): a prospective, multi-centre, randomised controll...

por Hagel, Stefan, Fiedler, Sandra, Hohn, Andreas, Brinkmann, Alexander, Frey, Otto R., Hoyer, Heike, Schlattmann, Peter, Kiehntopf, Michael, Roberts, Jason A., Pletz, Mathias W.
Publicado 2019

Personalized Piperacillin Dosing for the Critically Ill: A Retrospective Analysis of Clinical Experience with Dosing Software and Therapeutic Drug Monitoring to Optimize Antimicrob...

por Chiriac, Ute, Richter, Daniel C., Frey, Otto R., Röhr, Anka C., Helbig, Sophia, Preisenberger, Judit, Hagel, Stefan, Roberts, Jason A., Weigand, Markus A., Brinkmann, Alexander
Publicado 2021

Cerebrospinal Fluid Concentrations of Meropenem and Vancomycin in Ventriculitis Patients Obtained by TDM-Guided Continuous Infusion

por Tiede, Christoph, Chiriac, Ute, Dubinski, Daniel, Raimann, Florian J., Frey, Otto R., Röhr, Anka C., Wieduwilt, Anna, Eibach, Michael, Filmann, Natalie, Senft, Christian, Zacharowski, Kai, Seifert, Volker, Mersmann, Jan
Publicado 2021

Study protocol of REpeat versus SIngle ShoT Antibiotic prophylaxis in major Abdominal Surgery (RESISTAAS I): a prospective observational study of antibiotic prophylaxis practice fo...

por Murtha-Lemekhova, Anastasia, Fuchs, Juri, Teroerde, Miriam, Rau, Heike, Frey, Otto R, Hornuss, Daniel, Billeter, Adrian, Klotz, Rosa, Chiriac, Ute, Larmann, Jan, Weigand, Markus A, Probst, Pascal, Hoffmann, Katrin
Publicado 2022

Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian fore...

por Greppmair, Sebastian, Brinkmann, Alexander, Roehr, Anka, Frey, Otto, Hagel, Stefan, Dorn, Christoph, Marsot, Amélie, El-Haffaf, Ibrahim, Zoller, Michael, Saller, Thomas, Zander, Johannes, Schatz, Lea Marie, Scharf, Christina, Briegel, Josef, Minichmayr, Iris K., Wicha, Sebastian G., Liebchen, Uwe
Publicado 2023

Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial

por Hagel, Stefan, Bach, Friedhelm, Brenner, Thorsten, Bracht, Hendrik, Brinkmann, Alexander, Annecke, Thorsten, Hohn, Andreas, Weigand, Markus, Michels, Guido, Kluge, Stefan, Nierhaus, Axel, Jarczak, Dominik, König, Christina, Weismann, Dirk, Frey, Otto, Witzke, Dominic, Müller, Carsten, Bauer, Michael, Kiehntopf, Michael, Neugebauer, Sophie, Lehmann, Thomas, Roberts, Jason A., Pletz, Mathias W.
Publicado 2022

Correction to: Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized co...

por Hagel, Stefan, Bach, Friedhelm, Brenner, Thorsten, Bracht, Hendrik, Brinkmann, Alexander, Annecke, Thorsten, Hohn, Andreas, Weigand, Markus Alexander, Michels, Guido, Kluge, Stefan, Nierhaus, Axel, Jarczak, Dominik, König, Christina, Weismann, Dirk, Frey, Otto, Witzke, Dominic, Müller, Carsten, Bauer, Michael, Kiehntopf, Michael, Neugebauer, Sophie, Lehmann, Thomas, Roberts, Jason A., Pletz, Mathias W.
Publicado 2022