Metabolic regulation of neurodifferentiation in the adult brain

por Maffezzini, Camilla, Calvo-Garrido, Javier, Wredenberg, Anna, Freyer, Christoph
Publicado 2020

No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline

por Hagström, Erik, Freyer, Christoph, Battersby, Brendan J., Stewart, James B., Larsson, Nils-Göran
Publicado 2014

SUV3 helicase is required for correct processing of mitochondrial transcripts

por Clemente, Paula, Pajak, Aleksandra, Laine, Isabelle, Wibom, Rolf, Wedell, Anna, Freyer, Christoph, Wredenberg, Anna
Publicado 2015

Protocol for the derivation, culturing, and differentiation of human iPS-cell-derived neuroepithelial stem cells to study neural differentiation in vitro

por Calvo-Garrido, Javier, Winn, Dania, Maffezzini, Camilla, Wedell, Anna, Freyer, Christoph, Falk, Anna, Wredenberg, Anna
Publicado 2021

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

por Ameur, Adam, Stewart, James B., Freyer, Christoph, Hagström, Erik, Ingman, Max, Larsson, Nils-Göran, Gyllensten, Ulf
Publicado 2011

Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA

por Stewart, James Bruce, Freyer, Christoph, Elson, Joanna L, Wredenberg, Anna, Cansu, Zekiye, Trifunovic, Aleksandra, Larsson, Nils-Göran
Publicado 2008

Mitochondrial Polyadenylation Is a One-Step Process Required for mRNA Integrity and tRNA Maturation

por Bratic, Ana, Clemente, Paula, Calvo-Garrido, Javier, Maffezzini, Camilla, Felser, Andrea, Wibom, Rolf, Wedell, Anna, Freyer, Christoph, Wredenberg, Anna
Publicado 2016

Stable Isotope Labeling of Amino Acids in Flies (SILAF) Reveals Differential Phosphorylation of Mitochondrial Proteins Upon Loss of OXPHOS Subunits

por Schober, Florian A., Atanassov, Ilian, Moore, David, Calvo-Garrido, Javier, Moedas, Marco F., Wedell, Anna, Freyer, Christoph, Wredenberg, Anna
Publicado 2021

TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

por Milenkovic, Dusanka, Matic, Stanka, Kühl, Inge, Ruzzenente, Benedetta, Freyer, Christoph, Jemt, Elisabeth, Park, Chan Bae, Falkenberg, Maria, Larsson, Nils-Göran
Publicado 2013

Maintenance of respiratory chain function in mouse hearts with severely impaired mtDNA transcription

por Freyer, Christoph, Park, Chan Bae, Ekstrand, Mats I., Shi, Yonghong, Khvorostova, Julia, Wibom, Rolf, Falkenberg, Maria, Gustafsson, Claes M., Larsson, Nils-Göran
Publicado 2010

Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element

por Jemt, Elisabeth, Persson, Örjan, Shi, Yonghong, Mehmedovic, Majda, Uhler, Jay P., Dávila López, Marcela, Freyer, Christoph, Gustafsson, Claes M., Samuelsson, Tore, Falkenberg, Maria
Publicado 2015

Germline mtDNA mutations aggravate ageing and can impair brain development

por Ross, Jaime M., Stewart, James B., Hagström, Erik, Brené, Stefan, Mourier, Arnaud, Coppotelli, Giuseppe, Freyer, Christoph, Lagouge, Marie, Hoffer, Barry J., Olson, Lars, Larsson, Nils-Göran
Publicado 2013

Mutations in the mitochondrial tryptophanyl‐tRNA synthetase cause growth retardation and progressive leukoencephalopathy

por Maffezzini, Camilla, Laine, Isabelle, Dallabona, Cristina, Clemente, Paula, Calvo‐Garrido, Javier, Wibom, Rolf, Naess, Karin, Barbaro, Michela, Falk, Anna, Donnini, Claudia, Freyer, Christoph, Wredenberg, Anna, Wedell, Anna
Publicado 2019

Novel Mutation m.10372A>G in MT-ND3 Causing Sensorimotor Axonal Polyneuropathy

por Bruhn, Helene, Samuelsson, Kristin, Schober, Florian A., Engvall, Martin, Lesko, Nicole, Wibom, Rolf, Nennesmo, Inger, Calvo-Garrido, Javier, Press, Rayomand, Stranneheim, Henrik, Freyer, Christoph, Wedell, Anna, Wredenberg, Anna
Publicado 2021

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease

por Kauppila, Johanna H.K., Baines, Holly L., Bratic, Ana, Simard, Marie-Lune, Freyer, Christoph, Mourier, Arnaud, Stamp, Craig, Filograna, Roberta, Larsson, Nils-Göran, Greaves, Laura C., Stewart, James B.
Publicado 2016

Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo

por Pajak, Aleksandra, Laine, Isabelle, Clemente, Paula, El-Fissi, Najla, Schober, Florian A., Maffezzini, Camilla, Calvo-Garrido, Javier, Wibom, Rolf, Filograna, Roberta, Dhir, Ashish, Wedell, Anna, Freyer, Christoph, Wredenberg, Anna
Publicado 2019

Chorea, psychosis, acanthocytosis, and prolonged survival associated with ELAC2 mutations

por Paucar, Martin, Pajak, Aleksandra, Freyer, Christoph, Bergendal, Åsa, Döry, Margit, Laffita-Mesa, José Miguel, Stranneheim, Henrik, Lagerstedt-Robinson, Kristina, Savitcheva, Irina, Walker, Ruth H., Wedell, Anna, Wredenberg, Anna, Svenningsson, Per
Publicado 2018

SQSTM1/p62-Directed Metabolic Reprogramming Is Essential for Normal Neurodifferentiation

por Calvo-Garrido, Javier, Maffezzini, Camilla, Schober, Florian A., Clemente, Paula, Uhlin, Elias, Kele, Malin, Stranneheim, Henrik, Lesko, Nicole, Bruhn, Helene, Svenningsson, Per, Falk, Anna, Wedell, Anna, Freyer, Christoph, Wredenberg, Anna
Publicado 2019

C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis

por Gopalakrishna, Shreekara, Pearce, Sarah F, Dinan, Adam M, Rosenberger, Florian A, Cipullo, Miriam, Spåhr, Henrik, Khawaja, Anas, Maffezzini, Camilla, Freyer, Christoph, Wredenberg, Anna, Atanassov, Ilian, Firth, Andrew E, Rorbach, Joanna
Publicado 2019

A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma

por Siibak, Triinu, Clemente, Paula, Bratic, Ana, Bruhn, Helene, Kauppila, Timo E.S., Macao, Bertil, Rosenberger, Florian A., Lesko, Nicole, Wibom, Rolf, Naess, Karin, Nennesmo, Inger, Wedell, Anna, Peter, Bradley, Freyer, Christoph, Falkenberg, Maria, Wredenberg, Anna
Publicado 2017