The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets Factors

por Cooper, Stacy, Guo, Hong, Friedman, Alan D.
Publicado 2015

In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis

por Guo, Hong, Cooper, Stacy, Friedman, Alan D.
Publicado 2016

C/EBPα induces Ebf1 gene expression in common lymphoid progenitors

por Barberi, Theresa, Cui, Cheng, Friedman, Alan D.
Publicado 2020

Adoptive transfer of immature myeloid cells lacking NF‐κB p50 (p50‐IMC) impedes the growth of MHC‐matched high‐risk neuroblastoma

por Cui, Cheng, Barberi, Theresa, Suresh, Rahul, Friedman, Alan D.
Publicado 2021

Granulopoiesis Requires Increased C/EBPα Compared to Monopoiesis, Correlated with Elevated Cebpa in Immature G-CSF Receptor versus M-CSF Receptor Expressing Cells

por Ma, Ou, Hong, SunHwa, Guo, Hong, Ghiaur, Gabriel, Friedman, Alan D.
Publicado 2014

Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic...

por Zhang, Jing, Li, Li, Baldwin, Albert S., Friedman, Alan D., Paz-Priel, Ido
Publicado 2015

Deletion of NF-kB p50 alters murine glioblastoma tumor-associated macrophage polarization, reduces tumor growth and prolongs survival

por Barberi, Theresa, Martin, Allison, Harris-Bookman, Sarah, Lim, Michael, Friedman, Alan D
Publicado 2015

CCAAT/Enhancer Binding Protein β Controls Androgen Deprivation-Induced Senescence in Prostate Cancer Cells

por Barakat, David J., Zhang, Jing, Barberi, Theresa, Denmeade, Samuel R., Friedman, Alan D., Paz-Priel, Ido
Publicado 2015

Absence of myeloid Klf4 reduces prostate cancer growth with pro-atherosclerotic activation of tumor myeloid cells and infiltration of CD8 T cells

por Barakat, David J., Suresh, Rahul, Barberi, Theresa, Pienta, Kenneth J., Simons, Brian W., Friedman, Alan D.
Publicado 2018

NF-κB p50-deficient immature myeloid cell (p50-IMC) adoptive transfer slows the growth of murine prostate and pancreatic ductal carcinoma

por Suresh, Rahul, Barakat, David J, Barberi, Theresa, Zheng, Lei, Jaffee, Elizabeth, Pienta, Kenneth J, Friedman, Alan D
Publicado 2020

Twist-2 Controls Myeloid Lineage Development and Function

por Sharabi, Andrew B, Aldrich, Melissa, Sosic, Drazen, Olson, Eric N, Friedman, Alan D, Lee, Sung-Hyung, Chen, Si-Yi
Publicado 2008

HoxA9 binds and represses the Cebpa +8 kb enhancer

por Peng, Lei, Guo, Hong, Ma, Peilin, Sun, Yuqing, Dennison, Lauren, Aplan, Peter D., Hess, Jay L., Friedman, Alan D.
Publicado 2019

The C-terminal multimerization domain is essential for leukemia development by CBFβ-SMMHC in a mouse knockin model

por Zhao, Ling, Alkadi, Halah, Kwon, Erika M., Zhen, Tao, Lichtenberg, Jens, Alemu, Lemlem, Cheng, Jun, Friedman, Alan D., Liu, P. Paul
Publicado 2017

BRAF V600E-mutated metastatic pediatric Wilms tumor with complete response to targeted RAF/MEK inhibition

por Obasaju, Patience, Shahab, Shubin, Dunn, Emily, Rhee, Daniel S., Jiang, LiQun, Dome, Jeffrey S., Friedman, Alan D., Argani, Pedram, Pratilas, Christine A.
Publicado 2020

The assembly competence domain is essential for inv(16)-associated acute myeloid leukemia

por Kim, Hyung-Gyoon, LeGrand, Jason, Swindle, C. Scott, Nick, Heidi J., Oster, Robert A., Chen, Dongquan, Purohit-Ghelani, Sheetal, Cotta, Claudiu V., Ko, Rose, Gartland, Larry, Reddy, Vishnu, Hiebert, Scott W., Friedman, Alan D., Klug, Christopher A.
Publicado 2017