Considerations for Adapting Pre-existing Mechanistic Quantitative Systems Pharmacology Models for New Research Contexts

por Weis, Michael, Baillie, Rebecca, Friedrich, Christina
Publicado 2019

Using machine learning surrogate modeling for faster QSP VP cohort generation

por Myers, Renée C., Augustin, Florian, Huard, Jérémy, Friedrich, Christina M.
Publicado 2023

A Flexible Approach for Context‐Dependent Assessment of Quantitative Systems Pharmacology Models

por Ramanujan, Saroja, Chan, Jason R., Friedrich, Christina M., Thalhauser, Craig J.
Publicado 2019

Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level

por Moss, Ronald B., Pryor, Meghan McCabe, Baillie, Rebecca, Kudrycki, Katherine, Friedrich, Christina, Reed, Mike, Carlo, Dennis J.
Publicado 2020

Quantitative systems pharmacology model‐based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3‐kinase inhibitors

por Gadkar, Kapil, Friedrich, Christina, Hurez, Vincent, Ruiz, Maria‐Luisa, Dickmann, Leslie, Kumar Jolly, Mohit, Schutt, Leah, Jin, Jin, Ware, Joseph A., Ramanujan, Saroja
Publicado 2021

Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates

por Ramakrishnan, Vidya, Friedrich, Christina, Witt, Colleen, Sheehan, Robert, Pryor, Meghan, Atwal, Jasvinder K., Wildsmith, Kristin, Kudrycki, Katherine, Lee, Seung‐Hye, Mazer, Norman, Hofmann, Carsten, Fuji, Reina N., Jin, Jin Y., Ramanujan, Saroja, Dolton, Michael, Quartino, Angelica
Publicado 2022

A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics

por Ming, Jeffrey E, Abrams, Ruth E, Bartlett, Derek W, Tao, Mengdi, Nguyen, Tu, Surks, Howard, Kudrycki, Katherine, Kadambi, Ananth, Friedrich, Christina M, Djebli, Nassim, Goebel, Britta, Koszycki, Alex, Varshnaya, Meera, Elassal, Joseph, Banerjee, Poulabi, Sasiela, William J, Reed, Michael J, Barrett, Jeffrey S, Azer, Karim
Publicado 2017