Glutamine synthetase mutations that cause glutamine deficiency: mechanistic insights from molecular dynamics simulations

por Frieg, Benedikt, Homeyer, Nadine, Häussinger, Dieter, Gohlke, Holger
Publicado 2014

Molecular Mechanisms of Glutamine Synthetase Mutations that Lead to Clinically Relevant Pathologies

por Frieg, Benedikt, Görg, Boris, Homeyer, Nadine, Keitel, Verena, Häussinger, Dieter, Gohlke, Holger
Publicado 2016

Partially inserted nascent chain unzips the lateral gate of the Sec translocon

por Kater, Lukas, Frieg, Benedikt, Berninghausen, Otto, Gohlke, Holger, Beckmann, Roland, Kedrov, Alexej
Publicado 2019

Aqueous ionic liquids redistribute local enzyme stability via long-range perturbation pathways

por El Harrar, Till, Frieg, Benedikt, Davari, Mehdi D., Jaeger, Karl-Erich, Schwaneberg, Ulrich, Gohlke, Holger
Publicado 2021

Structural basis of lantibiotic recognition by the nisin resistance protein from Streptococcus agalactiae

por Khosa, Sakshi, Frieg, Benedikt, Mulnaes, Daniel, Kleinschrodt, Diana, Hoeppner, Astrid, Gohlke, Holger, Smits, Sander H. J.
Publicado 2016

Atomic Resolution Insights into pH Shift Induced Deprotonation Events in LS-Shaped Aβ(1–42) Amyloid Fibrils

por Becker, Nina, Frieg, Benedikt, Gremer, Lothar, Kupreichyk, Tatsiana, Gardon, Luis, Freiburg, Patrick, Neudecker, Philipp, Willbold, Dieter, Gohlke, Holger, Heise, Henrike
Publicado 2023

Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses

por Cukkemane, Abhishek, Becker, Nina, Zielinski, Mara, Frieg, Benedikt, Lakomek, Nils-Alexander, Heise, Henrike, Schröder, Gunnar F., Willbold, Dieter, Weiergräber, Oliver H.
Publicado 2021

Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels

por Kondapuram, Mahesh, Frieg, Benedikt, Yüksel, Sezin, Schwabe, Tina, Sattler, Christian, Lelle, Marco, Schweinitz, Andrea, Schmauder, Ralf, Benndorf, Klaus, Gohlke, Holger, Kusch, Jana
Publicado 2022

EDTA aggregates induce SYPRO orange-based fluorescence in thermal shift assay

por Kroeger, Tobias, Frieg, Benedikt, Zhang, Tao, Hansen, Finn K., Marmann, Andreas, Proksch, Peter, Nagel-Steger, Luitgard, Groth, Georg, Smits, Sander H. J., Gohlke, Holger
Publicado 2017

Molecular interactions of FG nucleoporin repeats at high resolution

por Ibáñez de Opakua, Alain, Geraets, James A., Frieg, Benedikt, Dienemann, Christian, Savastano, Adriana, Rankovic, Marija, Cima-Omori, Maria-Sol, Schröder, Gunnar F., Zweckstetter, Markus
Publicado 2022

Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein

por Frieg, Benedikt, Geraets, James A., Strohäker, Timo, Dienemann, Christian, Mavroeidi, Panagiota, Jung, Byung Chul, Kim, Woojin S., Lee, Seung-Jae, Xilouri, Maria, Zweckstetter, Markus, Schröder, Gunnar F.
Publicado 2022

The 3D structure of lipidic fibrils of α-synuclein

por Frieg, Benedikt, Antonschmidt, Leif, Dienemann, Christian, Geraets, James A., Najbauer, Eszter E., Matthes, Dirk, de Groot, Bert L., Andreas, Loren B., Becker, Stefan, Griesinger, Christian, Schröder, Gunnar F.
Publicado 2022

The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils

por Antonschmidt, Leif, Matthes, Dirk, Dervişoğlu, Rıza, Frieg, Benedikt, Dienemann, Christian, Leonov, Andrei, Nimerovsky, Evgeny, Sant, Vrinda, Ryazanov, Sergey, Giese, Armin, Schröder, Gunnar F., Becker, Stefan, de Groot, Bert L., Griesinger, Christian, Andreas, Loren B.
Publicado 2022

Cryo-EM of Aβ fibrils from mouse models find tg-APP(ArcSwe) fibrils resemble those found in patients with sporadic Alzheimer’s disease

por Zielinski, Mara, Peralta Reyes, Fernanda S., Gremer, Lothar, Schemmert, Sarah, Frieg, Benedikt, Schäfer, Luisa U., Willuweit, Antje, Donner, Lili, Elvers, Margitta, Nilsson, Lars N. G., Syvänen, Stina, Sehlin, Dag, Ingelsson, Martin, Willbold, Dieter, Schröder, Gunnar F.
Publicado 2023

Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects

por Gopalswamy, Mohanraj, Kroeger, Tobias, Bickel, David, Frieg, Benedikt, Akter, Shahina, Schott-Verdugo, Stephan, Viegas, Aldino, Pauly, Thomas, Mayer, Manuela, Przibilla, Julia, Reiners, Jens, Nagel-Steger, Luitgard, Smits, Sander H. J., Groth, Georg, Etzkorn, Manuel, Gohlke, Holger
Publicado 2022

Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization

por Bhatia, Sanil, Spanier, Lukas, Bickel, David, Dienstbier, Niklas, Woloschin, Vitalij, Vogt, Melina, Pols, Henrik, Lungerich, Beate, Reiners, Jens, Aghaallaei, Narges, Diedrich, Daniela, Frieg, Benedikt, Schliehe-Diecks, Julian, Bopp, Bertan, Lang, Franziska, Gopalswamy, Mohanraj, Loschwitz, Jennifer, Bajohgli, Baubak, Skokowa, Julia, Borkhardt, Arndt, Hauer, Julia, Hansen, Finn K., Smits, Sander H. J., Jose, Joachim, Gohlke, Holger, Kurz, Thomas
Publicado 2022