SARS-CoV-2 infection of human pluripotent stem cell-derived liver organoids reveals potential mechanisms of liver pathology

por Richards, Alexsia, Friesen, Max, Khalil, Andrew, Barrasa, M. Inmaculada, Gehrke, Lee, Jaenisch, Rudolf
Publicado 2022

Development of a physiological insulin resistance model in human stem cell–derived adipocytes

por Friesen, Max, Khalil, Andrew S., Barrasa, M. Inmaculada, Jeppesen, Jacob F., Mooney, David J., Jaenisch, Rudolf
Publicado 2022

LINE1-Mediated Reverse Transcription and Genomic Integration of SARS-CoV-2 mRNA Detected in Virus-Infected but Not in Viral mRNA-Transfected Cells

por Zhang, Liguo, Bisht, Punam, Flamier, Anthony, Barrasa, M. Inmaculada, Friesen, Max, Richards, Alexsia, Hughes, Stephen H., Jaenisch, Rudolf
Publicado 2023

Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease

por Friesen, Max, Camahort, Raymond, Lee, Youn-Kyoung, Xia, Fang, Gerszten, Robert E., Rhee, Eugene P., Deo, Rahul C., Cowan, Chad A.
Publicado 2017

Mitoregulin Controls β-Oxidation in Human and Mouse Adipocytes

por Friesen, Max, Warren, Curtis R., Yu, Haojie, Toyohara, Takafumi, Ding, Qiurong, Florido, Mary H.C., Sayre, Carolyn, Pope, Benjamin D., Goff, Loyal A., Rinn, John L., Cowan, Chad A.
Publicado 2020

Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy–induced toxicities

por Spetz, Johan K. E., Florido, Mary H. C., Fraser, Cameron S., Qin, Xingping, Choiniere, Jonathan, Yu, Stacey J., Singh, Rumani, Friesen, Max, Rubin, Lee L., Salem, Joe-Elie, Moslehi, Javid J., Sarosiek, Kristopher A.
Publicado 2022

Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype

por Roudnicky, Filip, Lan, Yanjun, Friesen, Max, Dernick, Gregor, Zhang, Jitao David, Staempfli, Andreas, Bordag, Natalie, Wagner-Golbs, Antje, Christensen, Klaus, Ebeling, Martin, Graf, Martin, Burcin, Mark, Meyer, Claas Aiko, Cowan, Chad A, Patsch, Christoph
Publicado 2019

The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance

por Dall’Agnese, Alessandra, Platt, Jesse M., Zheng, Ming M., Friesen, Max, Dall’Agnese, Giuseppe, Blaise, Alyssa M., Spinelli, Jessica B., Henninger, Jonathan E., Tevonian, Erin N., Hannett, Nancy M., Lazaris, Charalampos, Drescher, Hannah K., Bartsch, Lea M., Kilgore, Henry R., Jaenisch, Rudolf, Griffith, Linda G., Cisse, Ibrahim I., Jeppesen, Jacob F., Lee, Tong I., Young, Richard A.
Publicado 2022