A natural variant in ANP32B impairs influenza virus replication in human cells

por Staller, Ecco, Sheppard, Carol M., Baillon, Laury, Frise, Rebecca, Peacock, Thomas P., Sancho-Shimizu, Vanessa, Barclay, Wendy S.
Publicado 2021

Levels of Influenza A Virus Defective Viral Genomes Determine Pathogenesis in the BALB/c Mouse Model

por Penn, Rebecca, Tregoning, John S., Flight, Katie E., Baillon, Laury, Frise, Rebecca, Goldhill, Daniel H., Johansson, Cecilia, Barclay, Wendy S.
Publicado 2022

Characterising viable virus from air exhaled by H1N1 influenza-infected ferrets reveals the importance of haemagglutinin stability for airborne infectivity

por Singanayagam, Anika, Zhou, Jie, Elderfield, Ruth A., Frise, Rebecca, Ashcroft, Jonathan, Galiano, Monica, Miah, Shahjahan, Nicolaou, Laura, Barclay, Wendy S.
Publicado 2020

Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza Virus

por Peacock, Thomas P., Sheppard, Carol M., Lister, Margaret G., Staller, Ecco, Frise, Rebecca, Swann, Olivia C., Goldhill, Daniel H., Long, Jason S., Barclay, Wendy S.
Publicado 2023

Species difference in ANP32A underlies influenza A virus polymerase host restriction

por Long, Jason S., Giotis, Efstathios S., Moncorgé, Olivier, Frise, Rebecca, Mistry, Bhakti, James, Joe, Morisson, Mireille, Iqbal, Munir, Vignal, Alain, Skinner, Michael A., Barclay, Wendy S.
Publicado 2016

Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1

por Stölting, Helen, Baillon, Laury, Frise, Rebecca, Bonner, Katie, Hewitt, Richard J., Molyneaux, Philip L., Gore, Mindy L., Barclay, Wendy S., Saglani, Sejal, Lloyd, Clare M.
Publicado 2022

Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice

por Li, Hui, Bradley, Konrad C., Long, Jason S., Frise, Rebecca, Ashcroft, Jonathan W., Hartgroves, Lorian C., Shelton, Holly, Makris, Spyridon, Johansson, Cecilia, Cao, Bin, Barclay, Wendy S.
Publicado 2018

A self-amplifying RNA vaccine protects against SARS-CoV-2 (D614G) and Alpha variant of concern (B.1.1.7) in a transmission-challenge hamster model

por Frise, Rebecca, Baillon, Laury, Zhou, Jie, Kugathasan, Ruthiran, Peacock, Thomas P., Brown, Jonathan C., Samnuan, Karnyart, McKay, Paul F., Shattock, Robin J., Barclay, Wendy S.
Publicado 2022

Favipiravir-resistant influenza A virus shows potential for transmission

por Goldhill, Daniel H., Yan, Ada, Frise, Rebecca, Zhou, Jie, Shelley, Jennifer, Gallego Cortés, Ana, Miah, Shahjahan, Akinbami, Omolola, Galiano, Monica, Zambon, Maria, Lackenby, Angie, Barclay, Wendy S.
Publicado 2021

Omicron breakthrough infections in vaccinated or previously infected hamsters

por Zhou, Jie, Sukhova, Ksenia, Peacock, Thomas P., McKay, Paul F., Brown, Jonathan C., Frise, Rebecca, Baillon, Laury, Moshe, Maya, Kugathasan, Ruthiran, Shattock, Robin J., Barclay, Wendy S.
Publicado 2023

An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization

por Sheppard, Carol M., Goldhill, Daniel H., Swann, Olivia C., Staller, Ecco, Penn, Rebecca, Platt, Olivia K., Sukhova, Ksenia, Baillon, Laury, Frise, Rebecca, Peacock, Thomas P., Fodor, Ervin, Barclay, Wendy S.
Publicado 2023

Contact transmission of influenza virus between ferrets imposes a looser bottleneck than respiratory droplet transmission allowing propagation of antiviral resistance

por Frise, Rebecca, Bradley, Konrad, van Doremalen, Neeltje, Galiano, Monica, Elderfield, Ruth A., Stilwell, Peter, Ashcroft, Jonathan W., Fernandez-Alonso, Mirian, Miah, Shahjahan, Lackenby, Angie, Roberts, Kim L., Donnelly, Christl A., Barclay, Wendy S.
Publicado 2016

Evaluation of a human mucosal tissue explant model for SARS-CoV-2 replication

por Gordhan, Bhavna Gowan, Herrera, Carolina, Pillay, Azure-Dee, Seiphetlo, Thabiso, Ealand, Christopher Shawn, Machowski, Edith, Singh, Natasha, Seatholo, Ntombexolo, Otwombe, Kennedy, Lebina, Limakatso, Frise, Rebecca, Scarlatti, Gabriella, Chiodi, Francesca, Martinson, Neil, Fox, Julie, Kana, Bavesh Davandra
Publicado 2023

RNAi-based small molecule repositioning reveals clinically approved urea-based kinase inhibitors as broadly active antivirals

por Lesch, Markus, Luckner, Madlen, Meyer, Michael, Weege, Friderike, Gravenstein, Isabella, Raftery, Martin, Sieben, Christian, Martin-Sancho, Laura, Imai-Matsushima, Aki, Welke, Robert-William, Frise, Rebecca, Barclay, Wendy, Schönrich, Günther, Herrmann, Andreas, Meyer, Thomas F., Karlas, Alexander
Publicado 2019

Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model

por Lee, Leo Y, Zhou, Jie, Koszalka, Paulina, Frise, Rebecca, Farrukee, Rubaiyea, Baba, Keiko, Miah, Shahjahan, Shishido, Takao, Galiano, Monica, Hashimoto, Takashi, Omoto, Shinya, Uehara, Takeki, Mifsud, Edin J., Collinson, Neil, Kuhlbusch, Klaus, Clinch, Barry, Wildum, Steffen, Barclay, Wendy S., Hurt, Aeron C.
Publicado 2021

Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission

por Lee, Leo Yi Yang, Zhou, Jie, Frise, Rebecca, Goldhill, Daniel H., Koszalka, Paulina, Mifsud, Edin J., Baba, Kaoru, Noda, Takahiro, Ando, Yoshinori, Sato, Kenji, Yuki, Aoe-Ishikawa, Shishido, Takao, Uehara, Takeki, Wildum, Steffen, Zwanziger, Elke, Collinson, Neil, Kuhlbusch, Klaus, Clinch, Barry, Hurt, Aeron C., Barclay, Wendy S.
Publicado 2020

Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway

por Zhou, Jie, Peacock, Thomas P., Brown, Jonathan C., Goldhill, Daniel H., Elrefaey, Ahmed M.E., Penrice-Randal, Rebekah, Cowton, Vanessa M., De Lorenzo, Giuditta, Furnon, Wilhelm, Harvey, William T., Kugathasan, Ruthiran, Frise, Rebecca, Baillon, Laury, Lassaunière, Ria, Thakur, Nazia, Gallo, Giulia, Goldswain, Hannah, Donovan-Banfield, I'ah, Dong, Xiaofeng, Randle, Nadine P., Sweeney, Fiachra, Glynn, Martha C., Quantrill, Jessica L., McKay, Paul F., Patel, Arvind H., Palmarini, Massimo, Hiscox, Julian A., Bailey, Dalan, Barclay, Wendy S.
Publicado 2022

SARS-CoV-2 lateral flow assays for possible use in national covid-19 seroprevalence surveys (React 2): diagnostic accuracy study

por Moshe, Maya, Daunt, Anna, Flower, Barnaby, Simmons, Bryony, Brown, Jonathan C, Frise, Rebecca, Penn, Rebecca, Kugathasan, Ruthiran, Petersen, Claire, Stockmann, Helen, Ashby, Deborah, Riley, Steven, Atchison, Christina, Taylor, Graham P, Satkunarajah, Sutha, Naar, Lenny, Klaber, Robert, Badhan, Anjna, Rosadas, Carolina, Marchesin, Federica, Fernandez, Natalia, Sureda-Vives, Macià, Cheeseman, Hannah, O’Hara, Jessica, Shattock, Robin, Fontana, Gianluca, Pallett, Scott J C, Rayment, Michael, Jones, Rachael, Moore, Luke S P, Ashrafian, Hutan, Cherapanov, Peter, Tedder, Richard, McClure, Myra, Ward, Helen, Darzi, Ara, Elliott, Paul, Cooke, Graham S, Barclay, Wendy S
Publicado 2021