Shortening of Zika virus CD-loop reduces neurovirulence while preserving antigenicity

por Dinnon III, Kenneth H., Gallichotte, Emily N., Fritch, Ethan J., Menachery, Vineet D., Baric, Ralph S.
Publicado 2019

Comparative analysis of coronavirus genomic RNA structure reveals conservation in SARS-like coronaviruses

por Sanders, Wes, Fritch, Ethan J., Madden, Emily A., Graham, Rachel L., Vincent, Heather A., Heise, Mark T., Baric, Ralph S., Moorman, Nathaniel J.
Publicado 2020

Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C

por McKnight, Kevin L., Swanson, Karen V., Austgen, Kathryn, Richards, Cindy, Mitchell, Jonathan K., McGivern, David R., Fritch, Ethan, Johnson, John, Remlinger, Katja, Magid-Slav, Michal, Kapustina, Maryna, You, Shihyun, Lemon, Stanley M.
Publicado 2020

Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate

por Iserman, Christiane, Roden, Christine, Boerneke, Mark, Sealfon, Rachel, McLaughlin, Grace, Jungreis, Irwin, Park, Chris, Boppana, Avinash, Fritch, Ethan, Hou, Yixuan J., Theesfeld, Chandra, Troyanskaya, Olga G, Baric, Ralph S., Sheahan, Timothy P., Weeks, Kevin, Gladfelter, Amy S.
Publicado 2020

Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release

por Shiota, Tomoyuki, Li, Zhucui, Chen, Guan-Yuan, McKnight, Kevin L., Shirasaki, Takayoshi, Yonish, Bryan, Kim, Heyjeong, Fritch, Ethan J., Sheahan, Timothy P., Muramatsu, Masamichi, Kapustina, Maryna, Cameron, Craig E., Li, You, Zhang, Qibin, Lemon, Stanley M.
Publicado 2023

Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction

por Katsura, Hiroaki, Sontake, Vishwaraj, Tata, Aleksandra, Kobayashi, Yoshihiko, Edwards, Caitlin E., Heaton, Brook E., Konkimalla, Arvind, Asakura, Takanori, Mikami, Yu, Fritch, Ethan J., Lee, Patty J., Heaton, Nicholas S., Boucher, Richard C., Randell, Scott H., Baric, Ralph S., Tata, Purushothama Rao
Publicado 2020

Metatranscriptomics analysis reveals a novel transcriptional and translational landscape during Middle East respiratory syndrome coronavirus infection

por Fritch, Ethan J., Sanders, Wes, Sims, Amy C., Herring, Laura E., Barker, Natalie K., Schepmoes, Athena A., Weitz, Karl K., Texier, Jordan R., Dittmer, Dirk P., Graves, Lee M., Smith, Richard D., Waters, Katrina M., Moorman, Nathaniel J., Baric, Ralph S., Graham, Rachel L.
Publicado 2023

Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive protection across divergent subgroups

por Hutchinson, Geoffrey, Abiona, Olubukola, Ziwawo, Cynthia, Werner, Anne, Ellis, Daniel, Tsybovsky, Yaroslav, Leist, Sarah, Palandjian, Charis, West, Ande, Fritch, Ethan, Wang, Niangshuang, Wrapp, Daniel, Boyoglu-Barnum, Seyhan, Ueda, George, Baker, David, Kanekiyo, Masaru, McLellan, Jason, Baric, Ralph, King, Neil, Graham, Barney, Corbett, Kizzmekia
Publicado 2022

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

por Iserman, Christiane, Roden, Christine A., Boerneke, Mark A., Sealfon, Rachel S.G., McLaughlin, Grace A., Jungreis, Irwin, Fritch, Ethan J., Hou, Yixuan J., Ekena, Joanne, Weidmann, Chase A., Theesfeld, Chandra L., Kellis, Manolis, Troyanskaya, Olga G., Baric, Ralph S., Sheahan, Timothy P., Weeks, Kevin M., Gladfelter, Amy S.
Publicado 2020

Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera

por Hutchinson, Geoffrey B., Abiona, Olubukola M., Ziwawo, Cynthia T., Werner, Anne P., Ellis, Daniel, Tsybovsky, Yaroslav, Leist, Sarah R., Palandjian, Charis, West, Ande, Fritch, Ethan J., Wang, Nianshuang, Wrapp, Daniel, Boyoglu-Barnum, Seyhan, Ueda, George, Baker, David, Kanekiyo, Masaru, McLellan, Jason S., Baric, Ralph S., King, Neil P., Graham, Barney S., Corbett-Helaire, Kizzmekia S.
Publicado 2023

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

por Leist, Sarah R., Dinnon, Kenneth H., Schäfer, Alexandra, Tse, Longping V., Okuda, Kenichi, Hou, Yixuan J., West, Ande, Edwards, Caitlin E., Sanders, Wes, Fritch, Ethan J., Gully, Kendra L., Scobey, Trevor, Brown, Ariane J., Sheahan, Timothy P., Moorman, Nathaniel J., Boucher, Richard C., Gralinski, Lisa E., Montgomery, Stephanie A., Baric, Ralph S.
Publicado 2020

Stabilized coronavirus spike stem elicits a broadly protective antibody

por Hsieh, Ching-Lin, Werner, Anne P., Leist, Sarah R., Stevens, Laura J., Falconer, Ester, Goldsmith, Jory A., Chou, Chia-Wei, Abiona, Olubukola M., West, Ande, Westendorf, Kathryn, Muthuraman, Krithika, Fritch, Ethan J., Dinnon, Kenneth H., Schäfer, Alexandra, Denison, Mark R., Chappell, James D., Baric, Ralph S., Graham, Barney S., Corbett, Kizzmekia S., McLellan, Jason S.
Publicado 2021

Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice

por Puhl, Ana C., Gomes, Giovanni F., Damasceno, Samara, Fritch, Ethan J., Levi, James A., Johnson, Nicole J., Scholle, Frank, Premkumar, Lakshmanane, Hurst, Brett L., LeeMontiel, Felipe, Veras, Flavio P., Batah, Sabrina S., Fabro, Alexandre T., Moorman, Nathaniel J., Yount, Boyd L., Dickmander, Rebekah, Baric, Ralph, Pearce, Kenneth H., Cunha, Fernando Q., Alves-Filho, José C., Cunha, Thiago M., Ekins, Sean
Publicado 2021

Vandetanib Blocks the Cytokine Storm in SARS-CoV-2-Infected Mice

por Puhl, Ana C., Gomes, Giovanni F., Damasceno, Samara, Fritch, Ethan J., Levi, James A., Johnson, Nicole J., Scholle, Frank, Premkumar, Lakshmanane, Hurst, Brett L., Lee-Montiel, Felipe, Veras, Flavio P., Batah, Sabrina S., Fabro, Alexandre T., Moorman, Nathaniel J., Yount, Boyd L., Dickmander, Rebekah J., Baric, Ralph S., Pearce, Kenneth H., Cunha, Fernando Q., Alves-Filho, José C., Cunha, Thiago M., Ekins, Sean
Publicado 2022

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms

por Puhl, Ana C., Fritch, Ethan James, Lane, Thomas R., Tse, Longping V., Yount, Boyd L., Sacramento, Carol Queiroz, Tavella, Tatyana Almeida, Costa, Fabio Trindade Maranhão, Weston, Stuart, Logue, James, Frieman, Matthew, Premkumar, Lakshmanane, Pearce, Kenneth H., Hurst, Brett L., Andrade, Carolina Horta, Levi, James A., Johnson, Nicole J., Kisthardt, Samantha C., Scholle, Frank, Souza, Thiago Moreno L., Moorman, Nathaniel John, Baric, Ralph S., Madrid, Peter, Ekins, Sean
Publicado 2020

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms

por Puhl, Ana C., Fritch, Ethan J., Lane, Thomas R., Tse, Longping V., Yount, Boyd L., Sacramento, Carolina Q., Fintelman-Rodrigues, Natalia, Tavella, Tatyana Almeida, Maranhão Costa, Fabio Trindade, Weston, Stuart, Logue, James, Frieman, Matthew, Premkumar, Lakshmanane, Pearce, Kenneth H., Hurst, Brett L., Andrade, Carolina Horta, Levi, James A., Johnson, Nicole J., Kisthardt, Samantha C., Scholle, Frank, Souza, Thiago Moreno L., Moorman, Nathaniel John, Baric, Ralph S., Madrid, Peter B., Ekins, Sean
Publicado 2021

A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies

por Dinnon, Kenneth H., Leist, Sarah R., Okuda, Kenichi, Dang, Hong, Fritch, Ethan J., Gully, Kendra L., De la Cruz, Gabriela, Evangelista, Mia D., Asakura, Takanori, Gilmore, Rodney C., Hawkins, Padraig, Nakano, Satoko, West, Ande, Schäfer, Alexandra, Gralinski, Lisa E., Everman, Jamie L., Sajuthi, Satria P., Zweigart, Mark R., Dong, Stephanie, McBride, Jennifer, Cooley, Michelle R., Hines, Jesse B., Love, Miriya K., Groshong, Steve D., VanSchoiack, Alison, Phelan, Stefan J., Liang, Yan, Hether, Tyler, Leon, Michael, Zumwalt, Ross E., Barton, Lisa M., Duval, Eric J., Mukhopadhyay, Sanjay, Stroberg, Edana, Borczuk, Alain, Thorne, Leigh B., Sakthivel, Muthu K., Lee, Yueh Z., Hagood, James S., Mock, Jason R., Seibold, Max A., O’Neal, Wanda K., Montgomery, Stephanie A., Boucher, Richard C., Baric, Ralph S.
Publicado 2022

SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice

por Dinnon, Kenneth H., Leist, Sarah R., Okuda, Kenichi, Dang, Hong, Fritch, Ethan J., Gully, Kendra L., De la Cruz, Gabriela, Evangelista, Mia D., Asakura, Takanori, Gilmore, Rodney C., Hawkins, Padraig, Nakano, Satoko, West, Ande, Schäfer, Alexandra, Gralinski, Lisa E., Everman, Jamie L., Sajuthi, Satria P., Zweigart, Mark R., Dong, Stephanie, McBride, Jennifer, Cooley, Michelle R., Hines, Jesse B., Love, Miriya K., Groshong, Steve D., VanSchoiack, Alison, Phelan, Stefan J., Liang, Yan, Hether, Tyler, Leon, Michael, Zumwalt, Ross E., Barton, Lisa M., Duval, Eric J., Mukhopadhyay, Sanjay, Stroberg, Edana, Borczuk, Alain, Thorne, Leigh B., Sakthivel, Muthu K., Lee, Yueh Z., Hagood, James S., Mock, Jason R., Seibold, Max A., O’Neal, Wanda K., Montgomery, Stephanie A., Boucher, Richard C., Baric, Ralph S.
Publicado 2022

SARS-CoV-2 mRNA Vaccine Design Enabled by Prototype Pathogen Preparedness

por Corbett, Kizzmekia S., Edwards, Darin K., Leist, Sarah R., Abiona, Olubukola M., Boyoglu-Barnum, Seyhan, Gillespie, Rebecca A., Himansu, Sunny, Schäfer, Alexandra, Ziwawo, Cynthia T., DiPiazza, Anthony T., Dinnon, Kenneth H., Elbashir, Sayda M., Shaw, Christine A., Woods, Angela, Fritch, Ethan J., Martinez, David R., Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Hutchinson, Geoffrey B., Wu, Kai, Henry, Carole, Bahi, Kapil, Garcia-Dominguez, Dario, Ma, LingZhi, Renzi, Isabella, Kong, Wing-Pui, Schmidt, Stephen D., Wang, Lingshu, Zhang, Yi, Phung, Emily, Chang, Lauren A., Loomis, Rebecca J., Altaras, Nedim Emil, Narayanan, Elisabeth, Metkar, Mihir, Presnyak, Vlad, Liu, Cuiping, Louder, Mark K., Shi, Wei, Leung, Kwanyee, Yang, Eun Sung, West, Ande, Gully, Kendra L., Stevens, Laura J., Wang, Nianshuang, Wrapp, Daniel, Doria-Rose, Nicole A., Stewart-Jones, Guillaume, Bennett, Hamilton, Alvarado, Gabriela S., Nason, Martha C., Ruckwardt, Tracy J., McLellan, Jason S., Denison, Mark R., Chappell, James D., Moore, Ian N., Morabito, Kaitlyn M., Mascola, John R., Baric, Ralph S., Carfi, Andrea, Graham, Barney S.
Publicado 2020