Immunomodulatory mAbs as Tools to Investigate on Cis-Interaction of PD-1/PD-L1 on Tumor Cells and to Set Up Methods for Early Screening of Safe and Potent Combinatorial Treatments

por Vetrei, Cinzia, Passariello, Margherita, Froechlich, Guendalina, Rapuano Lembo, Rosa, Zambrano, Nicola, De Lorenzo, Claudia
Publicado 2021

New Insights on the Role of Anti-PD-L1 and Anti-CTLA-4 mAbs on Different Lymphocytes Subpopulations in TNBC

por Lembo, Rosa Rapuano, Manna, Lorenzo, Froechlich, Guendalina, Sasso, Emanuele, Passariello, Margherita, De Lorenzo, Claudia
Publicado 2022

Novel Combinations of Human Immunomodulatory mAbs Lacking Cardiotoxic Effects for Therapy of TNBC

por Vetrei, Cinzia, Passariello, Margherita, Froechlich, Guendalina, Rapuano Lembo, Rosa, Sasso, Emanuele, Zambrano, Nicola, De Lorenzo, Claudia
Publicado 2021

A long non-coding SINEUP RNA boosts semi-stable production of fully human monoclonal antibodies in HEK293E cells

por Sasso, Emanuele, Latino, Debora, Froechlich, Guendalina, Succoio, Mariangela, Passariello, Margherita, De Lorenzo, Claudia, Nicosia, Alfredo, Zambrano, Nicola
Publicado 2018

High-Throughput Monoclonal Antibody Discovery from Phage Libraries: Challenging the Current Preclinical Pipeline to Keep the Pace with the Increasing mAb Demand

por Zambrano, Nicola, Froechlich, Guendalina, Lazarevic, Dejan, Passariello, Margherita, Nicosia, Alfredo, De Lorenzo, Claudia, Morelli, Marco J., Sasso, Emanuele
Publicado 2022

Novel Human Anti-PD-L1 mAbs Inhibit Immune-Independent Tumor Cell Growth and PD-L1 Associated Intracellular Signalling

por Passariello, Margherita, D’Alise, Anna Morena, Esposito, Annachiara, Vetrei, Cinzia, Froechlich, Guendalina, Scarselli, Elisa, Nicosia, Alfredo, De Lorenzo, Claudia
Publicado 2019

One-Step Recovery of scFv Clones from High-Throughput Sequencing-Based Screening of Phage Display Libraries Challenged to Cells Expressing Native Claudin-1

por Sasso, Emanuele, Paciello, Rolando, D'Auria, Francesco, Riccio, Gennaro, Froechlich, Guendalina, Cortese, Riccardo, Nicosia, Alfredo, De Lorenzo, Claudia, Zambrano, Nicola
Publicado 2015

The common H232 STING allele shows impaired activities in DNA sensing, susceptibility to viral infection, and in monocyte cell function, while the HAQ variant possesses wild-type p...

por Froechlich, Guendalina, Finizio, Arianna, Napolano, Alessandra, Amiranda, Sara, De Chiara, Arianna, Pagano, Pasqualina, Mallardo, Massimo, Leoni, Guido, Zambrano, Nicola, Sasso, Emanuele
Publicado 2023

Generation of a Retargeted Oncolytic Herpes Virus Encoding Adenosine Deaminase for Tumor Adenosine Clearance

por Gentile, Chiara, Finizio, Arianna, Froechlich, Guendalina, D’Alise, Anna Morena, Cotugno, Gabriella, Amiranda, Sara, Nicosia, Alfredo, Scarselli, Elisa, Zambrano, Nicola, Sasso, Emanuele
Publicado 2021

Isolation of Two Novel Human Anti-CTLA-4 mAbs with Intriguing Biological Properties on Tumor and NK Cells

por Passariello, Margherita, Vetrei, Cinzia, Sasso, Emanuele, Froechlich, Guendalina, Gentile, Chiara, D’Alise, Anna Morena, Zambrano, Nicola, Scarselli, Elisa, Nicosia, Alfredo, De Lorenzo, Claudia
Publicado 2020

Replicative conditioning of Herpes simplex type 1 virus by Survivin promoter, combined to ERBB2 retargeting, improves tumour cell-restricted oncolysis

por Sasso, Emanuele, Froechlich, Guendalina, Cotugno, Gabriella, D’Alise, Anna Morena, Gentile, Chiara, Bignone, Veronica, De Lucia, Maria, Petrovic, Biljana, Campadelli-Fiume, Gabriella, Scarselli, Elisa, Nicosia, Alfredo, Zambrano, Nicola
Publicado 2020

Massive parallel screening of phage libraries for the generation of repertoires of human immunomodulatory monoclonal antibodies

por Sasso, Emanuele, D’Avino, Chiara, Passariello, Margherita, D’Alise, Anna Morena, Siciliano, Daniela, Esposito, Maria Luisa, Froechlich, Guendalina, Cortese, Riccardo, Scarselli, Elisa, Zambrano, Nicola, Nicosia, Alfredo, De Lorenzo, Claudia
Publicado 2018

Generation of a Novel Mesothelin-Targeted Oncolytic Herpes Virus and Implemented Strategies for Manufacturing

por Froechlich, Guendalina, Gentile, Chiara, Infante, Luigia, Caiazza, Carmen, Pagano, Pasqualina, Scatigna, Sarah, Cotugno, Gabriella, D’Alise, Anna Morena, Lahm, Armin, Scarselli, Elisa, Nicosia, Alfredo, Mallardo, Massimo, Sasso, Emanuele, Zambrano, Nicola
Publicado 2021

Integrity of the Antiviral STING-mediated DNA Sensing in Tumor Cells Is Required to Sustain the Immunotherapeutic Efficacy of Herpes Simplex Oncolytic Virus

por Froechlich, Guendalina, Caiazza, Carmen, Gentile, Chiara, D’Alise, Anna Morena, De Lucia, Maria, Langone, Francesca, Leoni, Guido, Cotugno, Gabriella, Scisciola, Vittorio, Nicosia, Alfredo, Scarselli, Elisa, Mallardo, Massimo, Sasso, Emanuele, Zambrano, Nicola
Publicado 2020

Retargeted and Multi-cytokine-Armed Herpes Virus Is a Potent Cancer Endovaccine for Local and Systemic Anti-tumor Treatment

por De Lucia, Maria, Cotugno, Gabriella, Bignone, Veronica, Garzia, Irene, Nocchi, Linda, Langone, Francesca, Petrovic, Biljana, Sasso, Emanuele, Pepe, Simona, Froechlich, Guendalina, Gentile, Chiara, Zambrano, Nicola, Campadelli-Fiume, Gabriella, Nicosia, Alfredo, Scarselli, Elisa, D’Alise, Anna Morena
Publicado 2020