Macrophages Mediate Increased CD8 T Cell Inflammation During Weight Loss in Formerly Obese Mice

por Surendar, Jayagopi, Karunakaran, Indulekha, Frohberger, Stefan J., Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P.
Publicado 2020

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils

por Frohberger, Stefan J., Ajendra, Jesuthas, Surendar, Jayagopi, Stamminger, Wiebke, Ehrens, Alexandra, Buerfent, Benedikt C., Gentil, Katrin, Hoerauf, Achim, Hübner, Marc P.
Publicado 2019

Adiponectin Limits IFN-γ and IL-17 Producing CD4 T Cells in Obesity by Restraining Cell Intrinsic Glycolysis

por Surendar, Jayagopi, Frohberger, Stefan J., Karunakaran, Indulekha, Schmitt, Vanessa, Stamminger, Wiebke, Neumann, Anna-Lena, Wilhelm, Christoph, Hoerauf, Achim, Hübner, Marc P.
Publicado 2019

IL-4 receptor dependent expansion of lung CD169(+) macrophages in microfilaria-driven inflammation

por Fercoq, Frédéric, Remion, Estelle, Frohberger, Stefan J., Vallarino-Lhermitte, Nathaly, Hoerauf, Achim, Le Quesne, John, Landmann, Frédéric, Hübner, Marc P., Carlin, Leo M., Martin, Coralie
Publicado 2019

S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis

por Frohberger, Stefan J., Fercoq, Frederic, Neumann, Anna-Lena, Surendar, Jayagopi, Stamminger, Wiebke, Ehrens, Alexandra, Karunakaran, Indulekha, Remion, Estelle, Vogl, Thomas, Hoerauf, Achim, Martin, Coralie, Hübner, Marc P.
Publicado 2020

ILC2s Control Microfilaremia During Litomosoides sigmodontis Infection in Rag2(-/-) Mice

por Reichwald, Julia J., Risch, Frederic, Neumann, Anna-Lena, Frohberger, Stefan J., Scheunemann, Johanna F., Lenz, Benjamin, Ehrens, Alexandra, Strutz, Wiebke, Schumak, Beatrix, Hoerauf, Achim, Hübner, Marc P.
Publicado 2022

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

por Hübner, Marc P., Ehrens, Alexandra, Koschel, Marianne, Dubben, Bettina, Lenz, Franziska, Frohberger, Stefan J., Specht, Sabine, Quirynen, Ludo, Lachau-Durand, Sophie, Tekle, Fetene, Baeten, Benny, Engelen, Marc, Mackenzie, Charles D., Hoerauf, Achim
Publicado 2019

Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis

por Scheunemann, Johanna F., Risch, Frederic, Reichwald, Julia J., Lenz, Benjamin, Neumann, Anna-Lena, Garbe, Stephan, Frohberger, Stefan J., Koschel, Marianne, Ajendra, Jesuthas, Rothe, Maximilian, Latz, Eicke, Coch, Christoph, Hartmann, Gunther, Schumak, Beatrix, Hoerauf, Achim, Hübner, Marc P.
Publicado 2023

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

por Hübner, Marc P., Martin, Coralie, Specht, Sabine, Koschel, Marianne, Dubben, Bettina, Frohberger, Stefan J., Ehrens, Alexandra, Fendler, Martina, Struever, Dominique, Mitre, Edward, Vallarino-Lhermitte, Nathaly, Gokool, Suzanne, Lustigman, Sara, Schneider, Manfred, Townson, Simon, Hoerauf, Achim, Scandale, Ivan
Publicado 2020

Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside

por Hübner, Marc P., Townson, Simon, Gokool, Suzanne, Tagboto, Senyo, Maclean, Mary J., Verocai, Guilherme G., Wolstenholme, Adrian J., Frohberger, Stefan J., Hoerauf, Achim, Specht, Sabine, Scandale, Ivan, Harder, Achim, Glenschek-Sieberth, Martin, Hahnel, Steffen R., Kulke, Daniel
Publicado 2021

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

por Hübner, Marc P., Koschel, Marianne, Struever, Dominique, Nikolov, Venelin, Frohberger, Stefan J., Ehrens, Alexandra, Fendler, Martina, Johannes, Iliana, von Geldern, Thomas W., Marsh, Kennan, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., Pfarr, Kenneth, Kempf, Dale J., Hoerauf, Achim
Publicado 2019

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis

por Ehrens, Alexandra, Lunde, Christopher S., Jacobs, Robert T., Struever, Dominique, Koschel, Marianne, Frohberger, Stefan J., Lenz, Franziska, Fendler, Martina, Turner, Joseph D., Ward, Stephen A., Taylor, Mark J., Freund, Yvonne R., Stefanakis, Rianna, Easom, Eric, Li, Xianfeng, Plattner, Jacob J., Hoerauf, Achim, Hübner, Marc P.
Publicado 2020

Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A

por Krome, Anna K., Becker, Tim, Kehraus, Stefan, Schiefer, Andrea, Steinebach, Christian, Aden, Tilman, Frohberger, Stefan J., López Mármol, Álvaro, Kapote, Dnyaneshwar, Jansen, Rolf, Chaverra-Muñoz, Lillibeth, Hübner, Marc P., Pfarr, Kenneth, Hesterkamp, Thomas, Stadler, Marc, Gütschow, Michael, König, Gabriele M., Hoerauf, Achim, Wagner, Karl G.
Publicado 2020

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

por von Geldern, Thomas W., Morton, Howard E., Clark, Rick F., Brown, Brian S., Johnston, Kelly L., Ford, Louise, Specht, Sabine, Carr, Robert A., Stolarik, Deanne F., Ma, Junli, Rieser, Matthew J., Struever, Dominique, Frohberger, Stefan J., Koschel, Marianne, Ehrens, Alexandra, Turner, Joseph D., Hübner, Marc P., Hoerauf, Achim, Taylor, Mark J., Ward, Stephen A., Marsh, Kennan, Kempf, Dale J.
Publicado 2019

Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models

por Hübner, Marc P., Gunderson, Emma, Vogel, Ian, Bulman, Christina A., Lim, K.C., Koschel, Marianne, Ehrens, Alexandra, Frohberger, Stefan J., Fendler, Martina, Tricoche, Nancy, Voronin, Denis, Steven, Andrew, Chi, Victor, Bakowski, Malina A., Woods, Ashley K., Petrassi, H. Michael, McNamara, Case W., Beerntsen, Brenda, Chappell, Laura, Sullivan, William, Taylor, Mark J., Turner, Joseph D., Hoerauf, Achim, Lustigman, Sara, Sakanari, Judy A.
Publicado 2019

Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

por Jacobs, Robert T., Lunde, Christopher S., Freund, Yvonne R., Hernandez, Vincent, Li, Xianfeng, Xia, Yi, Carter, David S., Berry, Pamela W., Halladay, Jason, Rock, Fernando, Stefanakis, Rianna, Easom, Eric, Plattner, Jacob J., Ford, Louise, Johnston, Kelly L., Cook, Darren A. N., Clare, Rachel, Cassidy, Andrew, Myhill, Laura, Tyrer, Hayley, Gamble, Joanne, Guimaraes, Ana F., Steven, Andrew, Lenz, Franziska, Ehrens, Alexandra, Frohberger, Stefan J., Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P., McNamara, Case W., Bakowski, Malina A., Turner, Joseph D., Taylor, Mark J., Ward, Stephen A.
Publicado 2019

AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis

por Hong, W. David, Benayoud, Farid, Nixon, Gemma L., Ford, Louise, Johnston, Kelly L., Clare, Rachel H., Cassidy, Andrew, Cook, Darren A. N., Siu, Amy, Shiotani, Motohiro, Webborn, Peter J. H., Kavanagh, Stefan, Aljayyoussi, Ghaith, Murphy, Emma, Steven, Andrew, Archer, John, Struever, Dominique, Frohberger, Stefan J., Ehrens, Alexandra, Hübner, Marc P., Hoerauf, Achim, Roberts, Adam P., Hubbard, Alasdair T. M., Tate, Edward W., Serwa, Remigiusz A., Leung, Suet C., Qie, Li, Berry, Neil G., Gusovsky, Fabian, Hemingway, Janet, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., O’Neill, Paul M.
Publicado 2019