Targeting TOR dependence in cancer

por Janes, Matthew R., Fruman, David A.
Publicado 2010

Akt and mTOR in B Cell Activation and Differentiation

por Limon, Jose J., Fruman, David A.
Publicado 2012

Novel pharmacological and dietary approaches to target mTOR in B-cell acute lymphoblastic leukemia

por Buono, Roberta, Alhaddad, Muneera, Fruman, David A.
Publicado 2023

Synthesis of a Complex Brasilicardin Analogue Utilizing a Cobalt-Catalyzed MHAT-Induced Radical Bicyclization Reaction

por Niman, Scott W., Buono, Roberta, Fruman, David A., Vanderwal, Christopher D.
Publicado 2023

MCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma

por Lee, J. Scott, Tang, Sarah S., Ortiz, Veronica, Vo, Thanh-Trang, Fruman, David A.
Publicado 2015

Resistance to mTOR Kinase Inhibitors in Lymphoma Cells Lacking 4EBP1

por Mallya, Sharmila, Fitch, Briana A., Lee, J. Scott, So, Lomon, Janes, Matthew R., Fruman, David A.
Publicado 2014

Effects of Novel Isoform-Selective Phosphoinositide 3-Kinase Inhibitors on Natural Killer Cell Function

por Yea, Sung Su, So, Lomon, Mallya, Sharmila, Lee, Jongdae, Rajasekaran, Kamalakannan, Malarkannan, Subramaniam, Fruman, David A.
Publicado 2014

Reduced eIF4E function impairs B-cell leukemia without altering normal B-lymphocyte function

por Chiu, Honyin, Buono, Roberta, Jackson, Leandra V., Herzog, Lee-or, Mallya, Sharmila, Conn, Crystal S., Ruggero, Davide, Fruman, David A.
Publicado 2021

mTOR inhibition enhances efficacy of dasatinib in ABL-rearranged Ph-like B-ALL

por Gotesman, Moran, Vo, Thanh-Trang T., Herzog, Lee-Or, Tea, Tiffeny, Mallya, Sharmila, Tasian, Sarah K., Konopleva, Marina, Fruman, David A.
Publicado 2018

mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells

por Beagle, Brandon R., Nguyen, Duc M., Mallya, Sharmila, Tang, Sarah S., Lu, Mengrou, Zeng, Zhihong, Konopleva, Marina, Vo, Thanh-Trang, Fruman, David A.
Publicado 2014

The CD11a and Endothelial Protein C Receptor Marker Combination Simplifies and Improves the Purification of Mouse Hematopoietic Stem Cells

por Karimzadeh, Alborz, Scarfone, Vanessa M., Varady, Erika, Chao, Connie, Grathwohl, Karin, Fathman, John W., Fruman, David A., Serwold, Thomas, Inlay, Matthew A.
Publicado 2018

Targeting eIF4F translation complex sensitizes B-ALL cells to tyrosine kinase inhibition

por Vo, Thanh-Trang, Herzog, Lee-or, Buono, Roberta, Lee, Jong-Hoon Scott, Mallya, Sharmila, Duong, Madeleine R., Thao, Joshua, Gotesman, Moran, Fruman, David A.
Publicado 2021

Efficacy of a Novel Bi-Steric mTORC1 Inhibitor in Models of B-Cell Acute Lymphoblastic Leukemia

por Lee, Bianca J., Mallya, Sharmila, Dinglasan, Nuntana, Fung, Amos, Nguyen, Tram, Herzog, Lee-or, Thao, Joshua, Lorenzana, Edward G., Wildes, David, Singh, Mallika, Smith, Jacqueline A. M., Fruman, David A.
Publicado 2021

The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation

por Chiu, Honyin, Mallya, Sharmila, Nguyen, Phuongthao, Mai, Annie, Jackson, Leandra V., Winkler, David G., DiNitto, Jonathan P., Brophy, Erin E., McGovern, Karen, Kutok, Jeffery L., Fruman, David A.
Publicado 2017

Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics

por Finicle, Brendan T, Eckenstein, Kazumi H, Revenko, Alexey S, Anderson, Brooke A, Wan, W Brad, McCracken, Alison N, Gil, Daniel, Fruman, David A, Hanessian, Stephen, Seth, Punit P, Edinger, Aimee L
Publicado 2023

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

por Ishak Gabra, Mari B., Yang, Ying, Li, Haiqing, Senapati, Parijat, Hanse, Eric A., Lowman, Xazmin H., Tran, Thai Q., Zhang, Lishi, Doan, Linda T., Xu, Xiangdong, Schones, Dustin E., Fruman, David A., Kong, Mei
Publicado 2020

Targeting eIF4F translation initiation complex with SBI-756 sensitises B lymphoma cells to venetoclax

por Herzog, Lee-or, Walters, Beth, Buono, Roberta, Lee, J. Scott, Mallya, Sharmila, Fung, Amos, Chiu, Honyin, Nguyen, Nancy, Li, Boyang, Pinkerton, Anthony B., Jackson, Michael R., Schneider, Robert J., Ronai, Ze’ev A., Fruman, David A.
Publicado 2020

MLN0128, a novel mTOR kinase inhibitor, disrupts survival signaling and triggers apoptosis in AML and AML stem/ progenitor cells

por Zeng, Zhihong, Wang, Rui-Yu, Qiu, Yi Hua, Mak, Duncan H., Coombes, Kevin, Yoo, Suk Young, Zhang, Qi, Jessen, Katti, Liu, Yi, Rommel, Christian, Fruman, David A., Kantarjian, Hagop M., Kornblau, Steven M., Andreeff, Michael, Konopleva, Marina
Publicado 2016

YAP-mediated mechanotransduction tunes the macrophage inflammatory response

por Meli, Vijaykumar S., Atcha, Hamza, Veerasubramanian, Praveen Krishna, Nagalla, Raji R., Luu, Thuy U., Chen, Esther Y., Guerrero-Juarez, Christian F., Yamaga, Kosuke, Pandori, William, Hsieh, Jessica Y., Downing, Timothy L., Fruman, David A., Lodoen, Melissa B., Plikus, Maksim V., Wang, Wenqi, Liu, Wendy F.
Publicado 2020

Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven Philadelphia chromosome–like acute B-cell lymphoblastic...

por Zhang, Qi, Shi, Ce, Han, Lina, Jain, Nitin, Roberts, Kathryn G., Ma, Helen, Cai, Tianyu, Cavazos, Antonio, Tabe, Yoko, Jacamo, Rodrigo O., Mu, Hong, Zhao, Yang, Wang, Jing, Wu, Shuo-Chieh, Cao, Fenglin, Zeng, Zhihong, Zhou, Jin, Mi, Yingchang, Jabbour, Elias J., Levine, Ross, Tasian, Sarah K., Mullighan, Charles G., Weinstock, David M., Fruman, David A., Konopleva, Marina
Publicado 2018