Drug Discovery Toward Antagonists of Methyl-Lysine Binding Proteins

por Herold, J. Martin, Ingerman, Lindsey A, Gao, Cen, Frye, Stephen V
Publicado 2011

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

por Baughman, Brandi M., Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A., Jessen, Henning J., Pearce, Kenneth H., Frye, Stephen V., Shears, Stephen B.
Publicado 2016

Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

por Baughman, Brandi M., Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A., Jessen, Henning J., Pearce, Kenneth H., Frye, Stephen V., Shears, Stephen B.
Publicado 2017

Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment

por Cruz Cruz, Joselyn, Allison, Kristen C., Page, Lauren S., Jenkins, Alexis J., Wang, Xiaodong, Earp, H. Shelton, Frye, Stephen V., Graham, Douglas K., Verneris, Michael R., Lee-Sherick, Alisa B.
Publicado 2023

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering

por Cui, Gaofeng, Botuyan, Maria Victoria, Drané, Pascal, Hu, Qi, Bragantini, Benoît, Thompson, James R., Schuller, David J., Detappe, Alexandre, Perfetti, Michael T., James, Lindsey I., Frye, Stephen V., Chowdhury, Dipanjan, Mer, Georges
Publicado 2023

Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins

por Lamb, Kelsey N., Dishman, Sarah N., Waybright, Jarod M., Engelberg, Isabelle A., Rectenwald, Justin M., Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Pearce, Kenneth H., James, Lindsey I., Frye, Stephen V.
Publicado 2021

Fused Tetrahydroquinolines Are Interfering with Your Assay

por Bashore, Frances M., Annor-Gyamfi, Joel, Du, Yuhong, Katis, Vittorio, Nwogbo, Felix, Flax, Raymond G., Frye, Stephen V., Pearce, Kenneth H., Fu, Haian, Willson, Timothy M., Drewry, David H., Axtman, Alison D.
Publicado 2023

Discovery of selective activators of PRC2 mutant EED-I363M

por Suh, Junghyun L., Barnash, Kimberly D., Abramyan, Tigran M., Li, Fengling, The, Juliana, Engelberg, Isabelle A., Vedadi, Masoud, Brown, Peter J., Kireev, Dmitri B., Arrowsmith, Cheryl H., James, Lindsey I., Frye, Stephen V.
Publicado 2019

Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing

por Moussa, Hagar F., Bsteh, Daniel, Yelagandula, Ramesh, Pribitzer, Carina, Stecher, Karin, Bartalska, Katarina, Michetti, Luca, Wang, Jingkui, Zepeda-Martinez, Jorge A., Elling, Ulrich, Stuckey, Jacob I., James, Lindsey I., Frye, Stephen V., Bell, Oliver
Publicado 2019

MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme

por Sufit, Alexandra, Lee-Sherick, Alisa B., DeRyckere, Deborah, Rupji, Manali, Dwivedi, Bhakti, Varella-Garcia, Marileila, Pierce, Angela M., Kowalski, Jeanne, Wang, Xiaodong, Frye, Stephen V., Earp, H. Shelton, Keating, Amy K., Graham, Douglas K.
Publicado 2016

MERTK activation drives osimertinib resistance in EGFR-mutant non–small cell lung cancer

por Yan, Dan, Huelse, Justus M., Kireev, Dmitri, Tan, Zikang, Chen, Luxiao, Goyal, Subir, Wang, Xiaodong, Frye, Stephen V., Behera, Madhusmita, Schneider, Frank, Ramalingam, Suresh S., Owonikoko, Taofeek, Earp, H. Shelton, DeRyckere, Deborah, Graham, Douglas K.
Publicado 2022

Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins

por Rectenwald, Justin M., Guduru, Shiva Krishna Reddy, Dang, Zhao, Collins, Leonard B., Liao, Yi-En, Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Kaufmann, Kyle W., Hammond, Scott M., Kireev, Dmitri B., Frye, Stephen V., Pearce, Kenneth H.
Publicado 2020

MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity

por Lee-Sherick, Alisa B., Jacobsen, Kristen M., Henry, Curtis J., Huey, Madeline G., Parker, Rebecca E., Page, Lauren S., Hill, Amanda A., Wang, Xiaodong, Frye, Stephen V., Earp, H. Shelton, Jordan, Craig T., DeRyckere, Deborah, Graham, Douglas K.
Publicado 2020

Therapeutic Targeting of MERTK and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia

por Summers, Ryan J., Jain, Juhi, Vasileiadi, Eleana, Smith, Brittany, Chimenti, Madison L., Yeung, Tsz Y., Kelvin, James, Wang, Xiaodong, Frye, Stephen V., Earp, H. Shelton, Tyner, Jeffrey W., Dreaden, Erik C., DeRyckere, Deborah, Graham, Douglas K.
Publicado 2022

Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8

por Ma, Anqi, Yu, Wenyu, Li, Fengling, Bleich, Rachel M., Herold, J. Martin, Butler, Kyle V., Norris, Jacqueline L., Korboukh, Victoria, Tripathy, Ashutosh, Janzen, William P., Arrowsmith, Cheryl H., Frye, Stephen V., Vedadi, Masoud, Brown, Peter J., Jin, Jian
Publicado 2014

UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor

por Zhang, Weihe, DeRyckere, Deborah, Hunter, Debra, Liu, Jing, Stashko, Michael A., Minson, Katherine A., Cummings, Christopher T., Lee, Minjung, Glaros, Trevor G., Newton, Dianne L., Sather, Susan, Zhang, Dehui, Kireev, Dmitri, Janzen, William P., Earp, H. Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Publicado 2014

The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cel...

por Vaughan, Robert M., Kupai, Ariana, Foley, Caroline A., Sagum, Cari A., Tibben, Bailey M., Eden, Hope E., Tiedemann, Rochelle L., Berryhill, Christine A., Patel, Varun, Shaw, Kevin M., Krajewski, Krzysztof, Strahl, Brian D., Bedford, Mark T., Frye, Stephen V., Dickson, Bradley M., Rothbart, Scott B.
Publicado 2020

MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing

por Vital, Tamara, Wali, Aminah, Butler, Kyle V., Xiong, Yan, Foster, Joseph P., Marcel, Shelsa S., McFadden, Andrew W., Nguyen, Valerie U., Bailey, Benton M., Lamb, Kelsey N., James, Lindsey I., Frye, Stephen V., Mosely, Amber L., Jin, Jian, Pattenden, Samantha G., Davis, Ian J.
Publicado 2023

Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer’s disease

por Du, Yuhong, Bradshaw, William J., Leisner, Tina M., Annor-Gyamfi, Joel K., Qian, Kun, Bashore, Frances M., Sikdar, Arunima, Nwogbo, Felix O., Ivanov, Andrey A., Frye, Stephen V., Gileadi, Opher, Brennan, Paul E., Levey, Allan I., Axtman, Alison D., Pearce, Kenneth H., Fu, Haian, Katis, Vittorio L.
Publicado 2023

Discovery of FERM domain protein–protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer’s disease

por Du, Yuhong, Bradshaw, William J., Leisner, Tina M., Annor-Gyamfi, Joel K., Qian, Kun, Bashore, Frances M., Sikdar, Arunima, Nwogbo, Felix O., Ivanov, Andrey A., Frye, Stephen V., Gileadi, Opher, Brennan, Paul E., Levey, Allan I., Axtman, Alison D., Pearce, Kenneth H., Fu, Haian, Katis, Vittorio L.
Publicado 2023