Mitochondrial Stress Induced p53 Attenuates HIF-1α Activity by Physical Association and Enhanced Ubiquitination

por Chowdhury, Anindya Roy, Long, Apple, Fuchs, Serge, Rustgi, Anil, Avadhani, Narayan G.
Publicado 2016

miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis

por Xu, Zhenhua, Bu, Yiwen, Chitnis, Nilesh, Koumenis, Costas, Fuchs, Serge Y., Diehl, J. Alan
Publicado 2016

The ssDNA-binding protein MEIOB acts as a dosage-sensitive regulator of meiotic recombination

por Guo, Rui, Xu, Yang, Leu, N Adrian, Zhang, Lei, Fuchs, Serge Y, Ye, Lan, Wang, P Jeremy
Publicado 2020

SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination

por Guan, Yongjuan, Lin, Huijuan, Leu, N Adrian, Ruthel, Gordon, Fuchs, Serge Y, Busino, Luca, Luo, Mengcheng, Wang, P Jeremy
Publicado 2022

Inflammatory signaling compromises cell responses to interferon alpha

por HuangFu, Wei-Chun, Qian, Juan, Liu, Chengbao, Liu, Jianghuai, Lokshin, Anna E., Baker, Darren P., Rui, Hallgeir, Fuchs, Serge Y
Publicado 2011

Pathogen Recognition Receptor Signaling Accelerates Phosphorylation-Dependent Degradation of IFNAR1

por Qian, Juan, Zheng, Hui, HuangFu, Wei-Chun, Liu, Jianghuai, Carbone, Christopher J., Leu, N. Adrian, Baker, Darren P., Fuchs, Serge Y.
Publicado 2011

Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor

por CHO, IL-RAE, OH, MYUNGJU, KOH, SANG SEOK, MALILAS, WARAPORN, SRISUTTEE, RATAKORN, JHUN, BYUNG HAK, PELLEGRINI, SANDRA, FUCHS, SERGE Y., CHUNG, YOUNG-HWA
Publicado 2012

Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intra-tumoral stromagenesis

por Cho, Christina, Mukherjee, Riddhita, Peck, Amy R., Sun, Yunguang, McBrearty, Noreen, Katlinski, Kanstantsin V., Gui, Jun, Govindaraju, Priya K., Puré, Ellen, Rui, Hallgeir, Fuchs, Serge Y.
Publicado 2020

Site-specific ubiquitination exposes a linear motif to promote interferon-α receptor endocytosis

por Kumar, K.G. Suresh, Barriere, Hervé, Carbone, Christopher J., Liu, Jianghuai, Swaminathan, Gayathri, Xu, Ping, Li, Ying, Baker, Darren P., Peng, Junmin, Lukacs, Gergely L., Fuchs, Serge Y.
Publicado 2007

Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer

por Kumar, Sushil, Srivastav, Ratnesh Kumar, Wilkes, David W., Ross, Taylor, Kim, Sabrina, Kowalski, Jules, Chatla, Srinivas, Zhang, Qing, Nayak, Anupma, Guha, Manti, Fuchs, Serge Y., Thomas, Christoforos, Chakrabarti, Rumela
Publicado 2018

PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma

por Pytel, Dariusz, Gao, Yan, Mackiewicz, Katarzyna, Katlinskaya, Yuliya V., Staschke, Kirk A., Paredes, Maria C. G., Yoshida, Akihiro, Qie, Shuo, Zhang, Gao, Chajewski, Olga S., Wu, Lawrence, Majsterek, Ireneusz, Herlyn, Meenhard, Fuchs, Serge Y., Diehl, J. Alan
Publicado 2016

Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer

por Lu, Zhen, Chen, Jinyun, Yu, Pengfei, Atherton, Matthew J., Gui, Jun, Tomar, Vivek S., Middleton, Justin D., Sullivan, Neil T., Singhal, Sunil, George, Subin S., Woolfork, Ashley G., Weljie, Aalim M., Hai, Tsonwin, Eruslanov, Evgeniy B., Fuchs, Serge Y.
Publicado 2022

A PERK-miR211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival

por Bu, Yiwen, Yoshida, Akihiro, Chitnis, Nilesh, Altman, Brian J., Tameire, Feven, Oran, Amanda, Gennaro, Victoria, Armeson, Kent E., McMahon, Steven, Wertheim, Gerald B., Van Dang, Chi, Ruggero, Davide, Koumenis, Constantinos, Fuchs, Serge Y., Diehl, J. Alan
Publicado 2017

Prolactin suppresses a progestin-induced CK5-positive cell population in luminal breast cancer through inhibition of progestin-driven BCL6 expression

por Sato, Takahiro, Tran, Thai H., Peck, Amy R., Girondo, Melanie A., Liu, Chengbao, Goodman, Chelain R., Neilson, Lynn M., Freydin, Boris, Chervoneva, Inna, Hyslop, Terry, Kovatich, Albert J., Hooke, Jeffrey A., Shriver, Craig D., Fuchs, Serge Y., Rui, Hallgeir
Publicado 2013

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumor progression

por Tameire, Feven, Verginadis, Ioannis I., Leli, Nektaria Maria, Polte, Christine, Conn, Crystal S., Ojha, Rani, Salas, Carlo, Chinga, Frank, Monroy, Alexandra. M., Fu, Weixuan, Wang, Paul, Kossenkov, Andrew, Ye, Jiangbin, Amaravadi, Ravi K., Ignatova, Zoya, Fuchs, Serge Y., Diehl, J. Alan, Ruggero, Davide, Koumenis, Constantinos
Publicado 2019

Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway

por Alicea-Torres, Kevin, Sanseviero, Emilio, Gui, Jun, Chen, Jinyun, Veglia, Filippo, Yu, Qiujin, Donthireddy, Laxminarasimha, Kossenkov, Andrew, Lin, Cindy, Fu, Shuyu, Mulligan, Charles, Nam, Brian, Masters, Gregory, Denstman, Fred, Bennett, Joseph, Hockstein, Neil, Rynda-Apple, Agnieszka, Nefedova, Yulia, Fuchs, Serge Y., Gabrilovich, Dmitry I.
Publicado 2021

Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury

por Bhattacharya, Sabyasachi, Katlinski, Kanstantsin V, Reichert, Maximilian, Takano, Shigetsugu, Brice, Angela, Zhao, Bin, Yu, Qiujing, Zheng, Hui, Carbone, Christopher J, Katlinskaya, Yuliya V, Leu, N Adrian, McCorkell, Kelly A, Srinivasan, Satish, Girondo, Melanie, Rui, Hallgeir, May, Michael J, Avadhani, Narayan G, Rustgi, Anil K, Fuchs, Serge Y
Publicado 2014

SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway

por Chen, Da-Yuan, Khan, Nazimuddin, Close, Brianna J., Goel, Raghuveera K., Blum, Benjamin, Tavares, Alexander H., Kenney, Devin, Conway, Hasahn L., Ewoldt, Jourdan K., Chitalia, Vipul C., Crossland, Nicholas A., Chen, Christopher S., Kotton, Darrell N., Baker, Susan C., Fuchs, Serge Y., Connor, John H., Douam, Florian, Emili, Andrew, Saeed, Mohsan
Publicado 2021

Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation

por Mucha, Bartosz, Qie, Shuo, Bajpai, Sagar, Tarallo, Vincenzo, Diehl, J. Nathaniel, Tedeschi, Frank, Zhou, Gao, Gao, Zhaofeng, Flashner, Samuel, Klein-Szanto, Andres J., Hibshoosh, Hanina, Masataka, Shimonosono, Chajewski, Olga S., Majsterek, Ireneusz, Pytel, Dariusz, Hatzoglou, Maria, Der, Channing J., Nakagawa, Hiroshi, Bass, Adam J., Wong, Kwok-Kin, Fuchs, Serge Y., Rustgi, Anil K., Jankowsky, Eckhard, Diehl, J. Alan
Publicado 2022

NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers

por Sun, Yunguang, Yang, Ning, Utama, Fransiscus E., Udhane, Sameer S., Zhang, Junling, Peck, Amy R., Yanac, Alicia, Duffey, Katherine, Langenheim, John F., Udhane, Vindhya, Xia, Guanjun, Peterson, Jess F., Jorns, Julie M., Nevalainen, Marja T., Rouet, Romain, Schofield, Peter, Christ, Daniel, Ormandy, Christopher J., Rosenberg, Anne L., Chervoneva, Inna, Tsaih, Shirng-Wern, Flister, Michael J., Fuchs, Serge Y., Wagner, Kay-Uwe, Rui, Hallgeir
Publicado 2021