Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy

por Wookey, Peter, Gupta, Pragya, Bittencourt, Lucas, Cheung, Shane, Hare, David, Furness, Sebastian
Publicado 2021

Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma

por Gupta, Pragya, Furness, Sebastian G. B., Bittencourt, Lucas, Hare, David L., Wookey, Peter J.
Publicado 2020

TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum

por Nguyen, Huynh T. H., Wood, Rhiannon J., Prawdiuk, Alexa R., Furness, Sebastian G. B., Xiao, Junhua, Murray, Simon S., Fletcher, Jessica L.
Publicado 2019

Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias

por Andreassen, Kim Vietz, Hjuler, Sara Toftegaard, Furness, Sebastian G., Sexton, Patrick M., Christopoulos, Arthur, Nosjean, Olivier, Karsdal, Morten Asser, Henriksen, Kim
Publicado 2014

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

por Ostrovskaya, Anna, Hick, Caroline, Hutchinson, Dana S., Stringer, Brett W., Wookey, Peter J., Wootten, Denise, Sexton, Patrick M., Furness, Sebastian G. B.
Publicado 2019

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in...

por Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Furness, Sebastian G.B., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Publicado 2016

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

por Harikumar, Kaleeckal G., Coudrat, Thomas, Desai, Aditya J., Dong, Maoqing, Dengler, Daniela G., Furness, Sebastian G. B., Christopoulos, Arthur, Wootten, Denise, Sergienko, Eduard A., Sexton, Patrick M., Miller, Laurence J.
Publicado 2021

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

por Dal Maso, Emma, Zhu, Yue, Pham, Vi, Reynolds, Christopher A., Deganutti, Giuseppe, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Wang, Ming-Wei, Sexton, Patrick M., Furness, Sebastian G.B., Wootten, Denise
Publicado 2018

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

por Mobbs, Jesse I., Belousoff, Matthew J., Harikumar, Kaleeckal G., Piper, Sarah J., Xu, Xiaomeng, Furness, Sebastian G. B., Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M., Miller, Laurence J., Sexton, Patrick M.
Publicado 2021

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

por Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Koole, Cassandra, Savage, Emilia E., Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G.B., Liu, Mengjie, Thompson, Philip E., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Publicado 2016

Structure and dynamics of the active Gs-coupled human secretin receptor

por Dong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M., Miller, Laurence J.
Publicado 2020

Phase-plate cryo-EM structure of a class B GPCR-G protein complex

por Liang, Yi-Lynn, Khoshouei, Maryam, Radjainia, Mazdak, Zhang, Yan, Glukhova, Alisa, Tarrasch, Jeffrey, Thal, David M, Furness, Sebastian G. B., Christopoulos, George, Coudrat, Thomas, Danev, Radostin, Baumeister, Wolfgang, Miller, Laurence J., Christopoulos, Arthur, Kobilka, Brian K, Wootten, Denise, Skiniotis, Georgios, Sexton, Patrick M.
Publicado 2017